The DOI matches its Crossref record.
Separation of Caveolae from Associated Microdomains of GPI-Anchored Proteins
Abstract
In situ coating of the surface of endothelial cells in rat lung with cationic colloidal silica particles was used to separate caveolae from detergent-insoluble membranes rich in glycosyl phosphatidylinositol (GPI)-anchored proteins but devoid of caveolin. Immunogold electron microscopy showed that ganglioside G M1 -enriched caveolae associated with an annular plasmalemmal domain enriched in GPI-anchored proteins. The purified caveolae contained molecular components required for regulated transport, including various lipid-anchored signaling molecules. Such specialized distinct microdomains may exist separately or together in the plasma membrane to organize signaling molecules and to process surface-bound ligands differentially.
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Citations
Cited by
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Dynamin-mediated Internalization of Caveolae
Henley, J. R., Krueger, E. W. A., Oswald, B. J., & McNiven, M. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.85 · Cited by 767
Membrane Compartmentation Is Required for Efficient T Cell Activation
Xavier, R., Brennan, T., Li, Q., McCormack, C., & Seed, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80577-4 · Cited by 690
Caveolae and intracellular trafficking of cholesterol
Fielding, C. J., & Fielding, P. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00140-5 · Cited by 116
Metadata
- Authors
- Schnitzer, J. E., McIntosh, D. P., Dvorak, A. M., Liu, J., & Oh, P.
- Venue
- Science
- Published
- 1995-09-08
- Volume
- 269
- Issue
- 5229
- Pages
- 1435-1439
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050465028
- Cited by
- 477
- References
- 0
- FWCI
- 15.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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