The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Phosphorodithioate DNA as a Potential Therapeutic Drug
Abstract
This article summarizes methods for the synthesis of phosphorodithioate-linked deoxyoligonucleotides and details an analysis of one of the distinctive properties of phosphorodithioate DNA oligomers, their ability to strongly inhibit human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT). Mechanistic studies indicate that oligomers of this type interfere with enzyme function by binding tightly to the active site for primer-template, which results in low or subnanomolar inhibitory constants. Although many of these studies have used deoxyoligocytidine analogs, a rationally designed approach has led to the discovery of a very active phosphorodithioate deoxyoligonucleotide inhibitor. This type of inhibitor, which binds strongly to the primer-template active site of HIV-1 RT, provides another type of potential therapeutic agent against HIV-1.
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Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
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A detailed model of reverse transcription and tests of crucial aspects
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Hu, B., Zhong, L., Weng, Y., Peng, L., Huang, Y., Zhao, Y., & Liang, X.-J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0207-x · Cited by 1,586
Kim, J., Chen, B., Reineke, T. M., Li, H., Eddaoudi, M., Moler, D. B., O'Keeffe, M., & Yaghi, O. M. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010825o · Cited by 832
Nouar, F., Eubank, J. F., Bousquet, T., Wojtas, L., Zaworotko, M. J., & Eddaoudi, M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710123s · Cited by 668
Metadata
- Authors
- Marshall, W. S., & Caruthers, M. H.
- Venue
- Science
- Published
- 1993-03-12
- Volume
- 259
- Issue
- 5101
- Pages
- 1564-1570
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065693353
- Cited by
- 223
- References
- 4
- FWCI
- 25.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marshall, W. S., & Caruthers, M. H. (1993). Phosphorodithioate DNA as a Potential Therapeutic Drug. Science. https://doi.org/10.1126/science.7681216
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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