The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons
Abstract
Cyclic adenosine monophosphate (cAMP)-dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensory neurons either in culture or in intact cell clusters. Energy transfer between the subunits, a measure of cytosolic cAMP concentration ([cAMP]), and compartmentation of the dissociated subunits were monitored by confocal fluorescence microscopy. Bath application of serotonin produced a much greater elevation of [cAMP] in the processes than in the central bodies of the neurons. The resulting gradients must drive a sizable centripetal flux of cAMP because direct microinjection of cAMP showed that it diffused readily. Perinuclear increases in [cAMP] slowly caused the translocation of the freed catalytic subunit into the nucleus to an extent proportional to the percentage of its dissociation from the regulatory subunit.
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Frost, W. N., Castellucci, V. F., Hawkins, R. D., & Kandel, E. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8266 · Cited by 334
Self-citationDale, N., Kandel, E., & Schacher, S. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-07-02232.1987 · Cited by 118
Self-citationOcorr, K. A., & Byrne, J. H. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90004-7 · Cited by 115
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Self-citationSilva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
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Chudakov, D. M., Matz, M. V., Lukyanov, S., & Lukyanov, K. A. (2010) · Physiological Reviews · doi:10.1152/physrev.00038.2009 · Cited by 1,375
The Molecular and Systems Biology of Memory
Kandel, E. R., Dudai, Y., & Mayford, M. R. (2014) · Cell · doi:10.1016/j.cell.2014.03.001 · Cited by 1,134
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Metadata
- Authors
- Bacskai, B. J., Hochner, B., Mahaut-Smith, M., Adams, S. R., Kaang, B.-K., Kandel, E. R., & Tsien, R. Y.
- Venue
- Science
- Published
- 1993-04-09
- Volume
- 260
- Issue
- 5105
- Pages
- 222-226
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2110048510
- Cited by
- 547
- References
- 3
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bacskai, B. J., Hochner, B., Mahaut-Smith, M., Adams, S. R., Kaang, B.-K., Kandel, E. R., & Tsien, R. Y. (1993). Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons. Science. https://doi.org/10.1126/science.7682336
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