The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity
Abstract
The critical discriminatory event in the activation of T lymphocytes bearing alpha beta T cell receptors (TCRs) is their interaction with a molecular complex consisting of a peptide bound to a major histocompatibility complex (MHC)-encoded class I or class II molecule on the surface of an antigen-presenting cell. The kinetics of binding were measured of a purified TCR to molecular complexes of a purified soluble analog of the murine MHC class I molecule H-2Ld (sH-2Ld) and a synthetic octamer peptide p2CL in a direct, real-time assay based on surface plasmon resonance. The kinetic dissociation rate of the MHC-peptide complex from the TCR was rapid (2.6 x 10(-2) second-1, corresponding to a half-time for dissociation of approximately 27 seconds), and the kinetic association rate was 2.1 x 10(5) M-1 second-1. The equilibrium constant for dissociation was approximately 10(-7) M. These values indicate that TCRs must interact with a multivalent array of MHC-peptide complexes to trigger T cell signaling.
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Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/341619a0 · Cited by 1,538
Takebe, Y., Seiki, M., Fujisawa, J.-I., Hoy, P., Yokota, K., Arai, K.-I., Yoshida, M., & Arai, N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.1.466-472.1988 · Cited by 1,330
Jönsson, U., Fägerstam, L. G., Ivarsson, B., Johnsson, B., Karlsson, R., Lundh, K., Löfås, S., Persson, B. S., Roos, H., & Rönnberg, I. (1991) · PubMed · Cited by 902
Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.
Kubo, R. T., Born, W., Kappler, J. W., Marrack, P., & Pigeon, M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.8.2736 · Cited by 747
Staerz, U. D., Rammensee, H., Benedetto, J. D., & Bevan, M. J. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.6.3994 · Cited by 663
Kaye, J., Porcelli, S., Tite, J., Jones, B., & Janeway, C. A. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.836 · Cited by 640
Feldman, H. A. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90084-x · Cited by 616
Oshannessy, D. J., Brighamburke, M., Soneson, K. K., Hensley, P., & Brooks, I. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1355 · Cited by 548
Isolation and characterization of antigen-la complexes involved in T cell recognition
Buus, S., Sette, A., Colon, S. M., Jenis, D. M., & Grey, H. M. (1986) · Cell · doi:10.1016/0092-8674(86)90822-6 · Cited by 467
Cited by
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
Porgador, A., Yewdell, J. W., Deng, Y., Bennink, J. R., & Germain, R. N. (1997) · Immunity · doi:10.1016/s1074-7613(00)80447-1 · Cited by 669
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
van der Merwe, P. A., Bodian, D. L., Daenke, S., Linsley, P., & Davis, S. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.393 · Cited by 551
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes
Garcia, K. C., Scott, C. A., Brunmark, A., Carbone, F. R., Peterson, P. A., Wilson, I. A., & Teyton, L. (1996) · Nature · doi:10.1038/384577a0 · Cited by 323
Metadata
- Authors
- Fisher, R. J., & Fivash, M.
- Venue
- Science
- Published
- 1995-04-07
- Volume
- 268
- Issue
- 5207
- Pages
- 115-117
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975807928
- Cited by
- 296
- References
- 29
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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