Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion
Abstract
Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic β cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K ATP ) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect K ATP channel activity, and thereby modulate insulin release.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SUR1 regulates the activity of the Kir6.2 pore, endowing it with sensitivity to inhibitory sulfonylurea drugs, K+ channel openers such as diazoxide, and stimulatory effects of Mg-nucleotides.
“Instead, it regulates the activity of the Kir6.2 pore, endowing it with sensitivity to inhibitory sulfonylurea drugs (hence its name), to K+ channel openers such as diazoxide, and to the stimulatory effects of Mg-nucleotides (5, 232, 621, 698).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [5]
Cites
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037 · see citing works
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0241-6 · Cited by 1,744 · see citing works
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766 · see citing works
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538 · see citing works
Inagaki, N., Gonoi, T., Iv, J. P. C., Wang, C.-Z., Aguilar-Bryan, L., Bryan, J., & Seino, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80124-5 · Cited by 974 · see citing works
Self-citationGlyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820 · see citing works
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Deeley, R. G., Westlake, C., & Cole, S. P. C. (2006) · Physiological Reviews · doi:10.1152/physrev.00035.2005 · Cited by 761 · see citing works
Association and Stoichiometry of KATP Channel Subunits
Clement, J. P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L., & Bryan, J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80321-9 · Cited by 692 · see citing works
Self-citationActivating Mutations in the<i>ABCC8</i>Gene in Neonatal Diabetes Mellitus
Babenko, A. P., Polak, M., Cavé, H., Busiah, K., Czernichow, P., Scharfmann, R., Bryan, J., Aguilar-Bryan, L., Vaxillaire, M., & Froguel, P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055068 · Cited by 655 · see citing works
Self-citationHypothalamic KATP channels control hepatic glucose production
Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645 · see citing works
Self-citationA Novel Sulfonylurea Receptor Forms with BIR (Kir6.2) a Smooth Muscle Type ATP-sensitive K+ Channel
Isomoto, S., Kondo, C., Yamada, M., Matsumoto, S., Higashiguchi, O., Horio, Y., Matsuzawa, Y., & Kurachi, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24321 · Cited by 544 · see citing works
Sulfonylurea Stimulation of Insulin Secretion
Proks, P., Reimann, F., Green, N., Gribble, F., & Ashcroft, F. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s368 · Cited by 510 · see citing works
The selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489 · see citing works
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works
Self-citationMitochondrial potassium transport: the K+ cycle
Garlid, K. D., & Paucek, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00108-7 · Cited by 365 · see citing works
A Systematic Review and Meta-Analysis of Hypoglycemia and Cardiovascular Events
Gangji, A. S., Cukierman, T., Gerstein, H. C., Goldsmith, C. H., & Clase, C. M. (2007) · Diabetes Care · doi:10.2337/dc06-1789 · Cited by 308 · see citing works
Structure of a Pancreatic ATP-Sensitive Potassium Channel
Li, N., Wu, J.-X., Ding, D., Cheng, J., Gao, N., & Chen, L. (2017) · Cell · doi:10.1016/j.cell.2016.12.028 · Cited by 252 · see citing works
Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders
Stanley, C. A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3651 · Cited by 239 · see citing works
WIMMERS, S., KARL, M., & STRAUSS, O. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.12.002 · Cited by 207 · see citing works
Gribble, F. M., Tucker, S. J., & Ashcroft, F. M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.00035.x · Cited by 161 · see citing works
New insights into KATP channel gene mutations and neonatal diabetes mellitus
Pipatpolkai, T., Usher, S., Stansfeld, P. J., & Ashcroft, F. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0351-y · Cited by 122 · see citing works
de Heer, J., & Holst, J. J. (2007) · Diabetes · doi:10.2337/db06-0738 · Cited by 115 · see citing works
Giri, D., Vignola, M. L., Gualtieri, A., Scagliotti, V., McNamara, P., Peak, M., Didi, M., Gaston-Massuet, C., & Senniappan, S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx318 · Cited by 91 · see citing works
Sulfonylurea and K+-Channel Opener Sensitivity of KATP Channels
Koster, J. C., Sha, Q., & Nichols, C. G. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.2.203 · Cited by 97 · see citing works
“The mechanistic basis of the biphasic response to tolbutamide is presently unknown (see discussion ), but it is clear that high affinity sulfonylurea interaction is with the SUR1 subunit (Aguilar-Bryan et al., 1995), whereas a low affinity action may occur through direct interaction with the Kir6.”
InfluentialSelf-citationThe UGDP Controversy: thirty-four years of contentious ambiguity laid to rest
Schwartz, T. B., & Meinert, C. L. (2004) · Perspectives in Biology and Medicine · doi:10.1353/pbm.2004.0071 · Cited by 85 · see citing works
Hu, S., Wang, S., Fanelli, B., Bell, P. A., Dunning, B. E., Geisse, S., Schmitz, R., & Boettcher, B. R. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39254-7 · Cited by 78 · see citing works
Babenko, A. P., Gonzalez, G., & Bryan, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01215-6 · Cited by 63 · see citing works
Self-citationYandrapalli, S., Jolly, G., Horblitt, A., Sanaani, A., & Aronow, W. S. (2017) · Postgraduate Medicine · doi:10.1080/00325481.2017.1358064 · Cited by 50 · see citing works
Gliclazide modified release: From once-daily administration to 24-hour blood glucose control
Harrower, A. (2000) · Metabolism · doi:10.1053/meta.2000.17823 · Cited by 30 · see citing works
Huang, W., Shaikh, S. N., Ganapathy, M. E., Hopfer, U., Leibach, F. H., Carter, A. L., & Ganapathy, V. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00219-1 · Cited by 22 · see citing works
Gros, L., Virsolvy, A., Salazar, G., Bataille, D., & Blache, P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0529 · Cited by 21 · see citing works
- Authors
- Aguilar-Bryan, L., Nichols, C. G., Wechsler, S. W., Clement, J. P., Boyd, A. E., González, G., Herrera-Sosa, H., Nguy, K., Bryan, J., & Nelson, D. A.
- Affiliations
- Departments of Cell Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
- Washington University in St. Louis (US)
- Baylor College of Medicine (US)
- Venue
- Science
- Published
- 1995-04-21
- Volume
- 268
- Issue
- 5209
- Pages
- 423-426
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148959338
- Cited by
- 1,315
- References
- 2
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 10 · 2023: 16 · 2022: 20 · 2021: 18 · 2020: 11 · 2019: 22 · 2018: 23 · 2017: 23 · 2016: 20 · 2015: 30 · 2014: 25 · 2013: 30 · 2012: 34
- FWCI
- 124.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01dk041898-01)
- National Heart, Lung, and Blood Institute (HL 45742, R01HL045742)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK44311, DK 41898, R01DK044311)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- sulfonylurea receptor, pancreatic beta cells, insulin secretion, sulfonylureas, ATP-sensitive potassium channels, nucleotide binding fold, cDNA cloning, type 2 diabetes, ATP sensing
- MeSH terms
- Insulin Secretion, Adenosine Diphosphate, Adenosine Triphosphate, Amino Acid Sequence, Animals, Base Sequence, Cell Line, Cloning, Molecular, Cricetinae, Insulin, Islets of Langerhans, Molecular Sequence Data, Phosphorylation, Receptors, Drug, Sulfonylurea Compounds, Transfection, Tumor Cells, Cultured, Potassium Channels, Sequence Alignment, Protein Structure, Secondary, Protein Folding, ATP-Binding Cassette Transporters, Potassium Channels, Inwardly Rectifying, Sulfonylurea Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
