The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein
Abstract
Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.
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Cites
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Cited by
Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Multifaceted Activities of the HIV-1 Transactivator of Transcription, Tat
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The Landscape of Human Proteins Interacting with Viruses and Other Pathogens
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Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
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Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
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Metadata
- Authors
- Li, C. J., Friedman, D. J., Wang, C., Metelev, V., & Pardee, A. B.
- Venue
- Science
- Published
- 1995-04-21
- Volume
- 268
- Issue
- 5209
- Pages
- 429-431
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074192294
- Cited by
- 580
- References
- 36
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, C. J., Friedman, D. J., Wang, C., Metelev, V., & Pardee, A. B. (1995). Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein. Science. https://doi.org/10.1126/science.7716549
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
