Cited by 164HIV Research and TreatmentT-cell and B-cell ImmunologyCell death mechanisms and regulation

Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells

Open access
Mueller, Yvonne M, De Rosa, Stephen C, Hutton, Justin A, Witek, James, Roederer, Mario, Altman, John D, Katsikis, Peter D·2001·Immunity

Abstract

Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.

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Crossref · 10.1016/s1074-7613(01)00246-1

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47 of 47 references verified0 citation errors · 0 not checkable

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  • CMV-specific CD8+ T cells are equally as susceptible to Fas-L/Fas-R induced apoptosis as the total pool of CD8+ T cells.

    “CMV-specific CD8+ T cells, rather than being resistant to apoptosis, are equally as susceptible to Fas-L/Fas-R induced apoptosis as the total pool of CD8+ T cells (Mueller et al. 2001).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Mueller et al. 2001

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Authors
Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D.
Affiliations
  • Hahnemann University Hospital (US)
  • National Institutes of Health (US)
  • Emory University (US)
Corresponding author
Katsikis, Peter D
Venue
Immunity
Publisher
Elsevier BV
Published
2001-12
Volume
15
Issue
6
Pages
871-882
ISSN
1074-7613 (ISSN-L)
OpenAlex
W2044870374
Cited by
164
References
48
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 4
FWCI
5.01
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01 AI46719, R01AI046719)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
HIV-specific CD8+ T cells, Fas ligand, T cell survival, T cell differentiation, effector memory T cells, CD45RA, L-selectin, cytotoxicity, IFN-gamma production, HIV infection, cytotoxic T lymphocytes
MeSH terms
Adult, Cell Differentiation, Cytomegalovirus, Cytotoxicity, Immunologic, Herpesvirus 4, Human, HIV, Humans, Immunologic Memory, Interferon-gamma, Macrophages, T-Lymphocytes, Cytotoxic, HIV Infections, Immunophenotyping, T-Lymphocyte Subsets, Apoptosis, Leukocyte Common Antigens, Coculture Techniques, fas Receptor, L-Selectin, Viral Load

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