Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
Open accessAbstract
Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CMV-specific CD8+ T cells are equally as susceptible to Fas-L/Fas-R induced apoptosis as the total pool of CD8+ T cells.
“CMV-specific CD8+ T cells, rather than being resistant to apoptosis, are equally as susceptible to Fas-L/Fas-R induced apoptosis as the total pool of CD8+ T cells (Mueller et al. 2001).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Mueller et al. 2001
Cites
1 retracted
Brodie, S. J., Patterson, B. K., Lewinsohn, D. A., Diem, K., Spach, D. H., Greenberg, P. D., Riddell, S. R., & Corey, L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8707 · Cited by 91 · see citing works
RetractedTwo subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · see citing works
Self-citationFadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321 · see citing works
Borrow, P., Lewicki, H. A., Hahn, B. H., Shaw, G. M., & Oldstone, M. B. A. (1994) · Journal of Virology · doi:10.1128/jvi.68.9.6103-6110.1994 · Cited by 1,880 · see citing works
Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia
Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., & Walker, B. D. (1997) · Science · doi:10.1126/science.278.5342.1447 · Cited by 1,832 · see citing works
Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA
Ogg, G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S. P., Segal, J. P., Cao, Y., Rowland‐Jones, S., Cerundolo, V., et al. (1998) · Science · doi:10.1126/science.279.5359.2103 · Cited by 1,381 · see citing works
Phenotypic and functional separation of memory and effector human CD8+ T cells
Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366 · see citing works
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
Matloubian, M., Concepcion, R. J., & Ahmed, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8056-8063.1994 · Cited by 1,162 · see citing works
Immune control of HIV-1 after early treatment of acute infection
Rosenberg, E. S., Altfeld, M. A., Poon, S. H. T., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K., D’Aquila, R. T., Goulder, P., & Walker, B. D. (2000) · Nature · doi:10.1038/35035103 · Cited by 1,002 · see citing works
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002 · see citing works
Finkel, T. H., Tudor‐Williams, G., Banda, N. K., Cotton, M. F., Curiel, T. J., Monks, C. R. F., Baba, T. W., Ruprecht, R. M., & Kupfer, A. (1995) · Nature Medicine · doi:10.1038/nm0295-129 · Cited by 946 · see citing works
Programmed Death of T Cells in HIV-1 Infection
Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R., & Miedema, F. F. (1992) · Science · doi:10.1126/science.1352911 · Cited by 898 · see citing works
Groux, H., Torpier, G., Monté, D., Mouton, Y., Capron, A., & Ameisen, J. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.2.331 · Cited by 881 · see citing works
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M. A., Dong, T., King, A., Ogg, G. S., Spiegel, H. M. L., Conlon, C., Spina, C. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.63 · Cited by 871 · see citing works
Banda, N. K., Bernier, J., Kurahara, D., Kurrle, R., Haigwood, N. L., Sékaly, R., & Finkel, T. H. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1099 · Cited by 668 · see citing works
Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein
Li, C. J., Friedman, D. J., Wang, C., Metelev, V., & Pardee, A. B. (1995) · Science · doi:10.1126/science.7716549 · Cited by 580 · see citing works
CD8 naive T cell counts decrease progressively in HIV-infected adults.
Roederer, M., Dubs, J. G., Anderson, M. T., Raju, P. A., Herzenberg, L. A., & Herzenberg, L. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117892 · Cited by 489 · see citing works
Self-citationEffros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS · doi:10.1097/00002030-199607000-00001 · Cited by 457 · see citing works
Katsikis, P. D., Wunderlich, E. S., Smith, C. A., Herzenberg, L. A., & Herzenberg, L. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2029 · Cited by 420 · see citing works
Self-citationMuro‐Cacho, C., Pantaleo, G., & Fauci, A. S. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5555 · Cited by 385 · see citing works
In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
Brodie, S. J., Lewinsohn, D. A., Patterson, B. K., Jiyamapa, D., Krieger, J. N., Corey, L., Greenberg, P. D., & Riddell, S. R. (1999) · Nature Medicine · doi:10.1038/4716 · Cited by 330 · see citing works
Geleziunas, R., Xu, W., Takeda, K., Ichijo, H., & Greene, W. C. (2001) · Nature · doi:10.1038/35071111 · Cited by 320 · see citing works
Programmed Cell Death in AIDS-Related HIV and SIV Infections
Gougeon, M., Garcia, S., Heeney, J. L., TSCHOPP, R. R., LECOEUR, H., Guétard, D., Rame, V., Dauguet, C., & Montagnier, L. (1993) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1993.9.553 · Cited by 309 · see citing works
Badley, A. D., McElhinny, J. A., Leibson, P. J., Lynch, D. H., Alderson, M. R., & Paya, C. V. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.199-206.1996 · Cited by 302 · see citing works
Shankar, P., Russo, M. L., Harnisch, B. A., Patterson, M., Skolnik, P. R., & Lieberman, J. (2000) · Blood · doi:10.1182/blood.v96.9.3094 · Cited by 285 · see citing works
Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes
Brown, S. B., & Savill, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.480 · Cited by 276 · see citing works
Estaquier, J., Idziorek, T., Zou, W., Émilie, D., Farber, C., Bourez, J. M., & Ameisen, J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1759 · Cited by 273 · see citing works
Gray, C. M., Lawrence, J., Schapiro, J., Altman, J. D., Winters, M. A., Crompton, M., Loi, M., Kundu‐Raychaudhuri, S., Davis, M. M., & Merigan, T. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1780 · Cited by 270 · see citing works
Self-citationXu, X., Laffert, B., Screaton, G. R., Kraft, M. S., Wolf, D., Kolanus, W., Mongkolsapay, J., McMichael, A. J., & Baur, A. S. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.9.1489 · Cited by 242 · see citing works
Kiener, P. A., Davis, P. M., Rankin, B. M., Klebanoff, S. J., Ledbetter, J. A., Starling, G. C., & Liles, W. C. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1594 · Cited by 201 · see citing works
Xu, X.-N., Screaton, G. R., Gotch, F. M., Dong, T., Tan, R., Almond, N. M., Walker, B., Stebbings, R., Kent, K. A., Nagata, S., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.1.7 · Cited by 187 · see citing works
Dockrell, D. H., Badley, A. D., Villacian, J. S., Heppelmann, C. J. H., Algeciras, A., Ziesmer, S., Yagita∥, H., Lynch, D. H., Roche, P. C., Leibson, P. J., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1171 · Cited by 134 · see citing works
Tang, M. L. K., Steeber, D. A., Zhang, X., & Tedder, T. F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.5113 · Cited by 128 · see citing works
Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome
Tan, R., Xu, X., Ogg, G. S., Hansasuta, P., Dong, T., Rostron, T., Luzzi, G. A., Conlon, C. P., Screaton, G. R., McMichael, A. J., et al. (1999) · Blood · doi:10.1182/blood.v93.5.1506 · Cited by 122 · see citing works
Vlahakis, S. R., Algeciras-Schimnich, A., Bou, G., Heppelmann, C. J. H., Villası́s-Keever, A., Collman, R. G., & Payá, C. V. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11109 · Cited by 94 · see citing works
Bofill, M., Gombert, W. M., Borthwick, N., Akbar, A. N., McLaughlin, J., Lee, C. A., Johnson, M. A., Pinching, A. J., & Janossy, G. (1995) · Europe PMC (PubMed Central) · Cited by 84 · see citing works
Kuroda, M. J., Schmitz, J. E., Charini, W. A., Nickerson, C. E., Lord, C. I., Forman, M. A., & Letvin, N. L. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1573-1579.1999 · Cited by 78 · see citing works
Baars, P. A., Ribeiro-do-Couto, L. M., Leusen, J. H. W., Hooibrink, B., Kuijpers, T. W., Lens, S. M. A., & van Lier, R. A. W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1910 · Cited by 73 · see citing works
Tateyama, M., Oyaizu, N., McCloskey, T. W., Than, S., & Pahwa, S. G. (2000) · Blood · doi:10.1182/blood.v96.1.195 · Cited by 72 · see citing works
Tanner, J. E., & Alfieri, C. (1999) · Blood · doi:10.1182/blood.v94.10.3439.422k23_3439_3447 · Cited by 65 · see citing works
Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals
Katsikis, P. D., García‐Ojeda, M. E., Wunderlich, E. S., Smith, C. A., Yagita∥, H., Okumura, K., Kayagaki, N., Alderson, M. R., Herzenberg, L. A., Herzenberg, L. A., et al. (1996) · International Immunology · doi:10.1093/intimm/8.8.1311 · Cited by 57 · see citing works
Self-citationKuroda, M. J., Schmitz, J. E., Seth, A., Veazey, R. S., Nickerson, C. E., Lifton, M. A., Dailey, P. J., Forman, M. A., Rácz, P., Tenner‐Racz, K., et al. (2000) · Blood · doi:10.1182/blood.v96.4.1474 · Cited by 48 · see citing works
Pantaleo, G., Soudeyns, H., Demarest, J. F., Vaccarezza, M., Graziosi, C., Paolucci, S., Daucher, M., Cohen, O. J., Denis, F., Biddison, W. E., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271213 · Cited by 43 · see citing works
Katsikis, P. D. (1997) · International Immunology · doi:10.1093/intimm/9.6.835 · Cited by 40 · see citing works
Self-citationEpstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-6
(2000) · Pure Amsterdam UMC · doi:10.1002/1521-4141(200007)30:7 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,599 · see citing works
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556 · see citing works
Migueles, S. A., Laborico, A. C., Shupert, W. L., Sabbaghian, M. S., Rabin, R. L., Hallahan, C. W., van Baarle, D., Kostense, S., Miedema, F. F., McLaughlin, M. E., et al. (2002) · Nature Immunology · doi:10.1038/ni845 · Cited by 1,004 · see citing works
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061496 · Cited by 889 · see citing works
Self-citationThe who's who of <scp>T</scp> ‐cell differentiation: Human memory <scp>T</scp> ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817 · see citing works
Self-citationCampbell, J. P., & Turner, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00648 · Cited by 692 · see citing works
T Cell Dynamics in HIV-1 Infection
Douek, D. C., Picker, L. J., & Koup, R. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141053 · Cited by 568 · see citing works
Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Price, D. A., Guenaga, J., Casazza, J. P., Kuruppu, J. C., Yazdani, J., Migueles, S. A., Connors, M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.3.1160-1168.2004 · Cited by 382 · see citing works
Self-citationMolecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets
Willinger, T., Freeman, T. C., Hasegawa, H., McMichael, A. J., & Callan, M. F. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5895 · Cited by 256 · see citing works
CD57+ T lymphocytes and functional immune deficiency
Focosi, D., Bestagno, M., Burrone, Ó. R., & Petrini, M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809566 · Cited by 253 · see citing works
Duraiswamy, J., Ibegbu, C., Masopust, D., Miller, J. D., Araki, K., Doho, G., Tata, P., Sk, G., Zilliox, M. J., Nakaya, H. I., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001783 · Cited by 246 · see citing works
Apoptosis as an HIV strategy to escape immune attack
Gougeon, M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1087 · Cited by 221 · see citing works
Beyond six colors: A new era in flow cytometry
Rosa, S. C. D., Brenchley, J. M., & Roederer, M. (2003) · Nature Medicine · doi:10.1038/nm0103-112 · Cited by 208 · see citing works
Self-citationFackler, O., & Baur, A. S. (2002) · Immunity · doi:10.1016/s1074-7613(02)00307-2 · Cited by 203 · see citing works
Virus Infection and Death Receptor-Mediated Apoptosis
Zhou, X., Jiang, W., Liu, Z., Liu, S., & Liang, X. (2017) · Viruses · doi:10.3390/v9110316 · Cited by 197 · see citing works
Yamamoto, T., Price, D. A., Casazza, J. P., Ferrari, G., Nason, M., Chattopadhyay, P. K., Roederer, M., Emma Gostick, D., Katsikis, P. D., Douek, D. C., et al. (2011) · Blood · doi:10.1182/blood-2010-11-317297 · Cited by 191 · see citing works
Self-citationChronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion
Bucks, C. M., Norton, J., Boesteanu, A. C., Mueller, Y. M., & Katsikis, P. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800997 · Cited by 187 · see citing works
Self-citationHide, shield and strike back: how HIV-infected cells avoid immune eradication
Peterlin, B. M., & Trono, D. (2003) · Nature reviews. Immunology · doi:10.1038/nri998 · Cited by 176 · see citing works
Petrovas, C., Price, D. A., Mattapallil, J. J., Ambrozak, D. R., Geldmacher, C., Cecchinato, V., Vaccari, M., Tryniszewska, E. A., Emma Gostick, D., Roederer, M., et al. (2007) · Blood · doi:10.1182/blood-2007-01-069112 · Cited by 172 · see citing works
Self-citationPremature ageing of the immune system: the cause of AIDS?
Appay, V., & Rowland-Jones, S. L. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02338-4 · Cited by 173 · see citing works
Coinfection With HIV-1 and HCV—A One-Two Punch
Kim, A. Y., & Chung, R. T. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.040 · Cited by 170 · see citing works
Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells
Hale, M. R., Mesojednik, T. D., Ibarra, G. S. R., Sahni, J., Bernard, A., Sommer, K., Scharenberg, A. M., Rawlings, D. J., & Wagner, T. A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.12.023 · Cited by 166 · see citing works
Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection
Price, D. A., Asher, T. E., Wilson, N. A., Nason, M., Brenchley, J. M., Metzler, I. S., Venturi, V., Emma Gostick, D., Chattopadhyay, P. K., Roederer, M., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081127 · Cited by 155 · see citing works
Self-citationRegulatory T Cells Secreting IL-10 Dominate the Immune Response to EBV Latent Membrane Protein 1
Marshall, N. A., Vickers, M. A., & Barker, R. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.6183 · Cited by 152 · see citing works
Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
Blattman, J. N., Wherry, E. J., Ha, S., der Most, R. G. V., & Ahmed, R. (2009) · Journal of Virology · doi:10.1128/jvi.02524-08 · Cited by 142 · see citing works
Lessons from the study of T-cell differentiation in persistent human virus infection
Appay, V., & Rowland‐Jones, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.02.007 · Cited by 136 · see citing works
IL-15 enhances survival and function of HIV-specific CD8+ T cells
Mueller, Y. M., Bojczuk, P. M., Halstead, E. S., Kim, A. H. J., Witek, J., Altman, J. D., & Katsikis, P. D. (2003) · Blood · doi:10.1182/blood-2002-07-1957 · Cited by 134 · see citing works
Self-citationHIV-specific CD8+ T cells and HIV eradication
Jones, R. B., & Walker, B. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci80566 · Cited by 131 · see citing works
Ochsenbein, A. F., Riddell, S. R., Brown, M., Corey, L., Baerlocher, G. M., Lansdorp, P. M., & Greenberg, P. D. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040717 · Cited by 131 · see citing works
Mueller, Y. M., Petrovas, C., Bojczuk, P. M., Dimitriou, I. D., Beer, B., Silvera, P. M., Villinger, F. J., Cairns, J. S., Gracely, E. J., Lewis, M. G., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.8.4877-4885.2005 · Cited by 119 · see citing works
Self-citationPetrovas, C., Chaon, B., Ambrozak, D. R., Price, D. A., Melenhorst, J. J., Hill, B. J., Geldmacher, C., Casazza, J. P., Chattopadhyay, P. K., Roederer, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900182 · Cited by 114 · see citing works
Self-citationMechanisms of CD8 + T cell‐mediated suppression of HIV/SIV replication
McBrien, J. B., Kumar, N., & Silvestri, G. (2018) · European Journal of Immunology · doi:10.1002/eji.201747172 · Cited by 107 · see citing works
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works
Apoptosis of uninfected cells induced by HIV envelope glycoproteins
Ahr, B., Robert-Hebmann, V., Devaux, C. A., & Biard‐Piechaczyk, M. (2004) · Retrovirology · doi:10.1186/1742-4690-1-12 · Cited by 105 · see citing works
Mueller, Y. M., Do, D. H., Altork, S. R., Artlett, C. M., Gracely, E. J., Katsetos, C. D., Legido, A., Villinger, F. J., Altman, J. D., Brown, C. R., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.350 · Cited by 102 · see citing works
Self-citationHolm, G. H., & Gabuzda, D. H. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6299-6311.2005 · Cited by 95 · see citing works
Fraietta, J. A., Mueller, Y. M., Yang, G., Boesteanu, A. C., Gracias, D. T., Do, D. H., Hope, J. L., Kathuria, N., McGettigan, S. E., Lewis, M. G., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003658 · Cited by 93 · see citing works
Self-citationHIV: current opinion in escapology
Klenerman, P., Wu, Y., & Phillips, R. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00339-9 · Cited by 92 · see citing works
Ravkov, E. V., Myrick, C., & Altman, J. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2461 · Cited by 89 · see citing works
Self-citationYue, F. Y., Kovacs, C. M., Dimayuga, R. C., Parks, P., & Ostrowski, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2476 · Cited by 88 · see citing works
The role of CD8+ T-cell response in HIV infection.
Benito, J. M., López, M., & Soriano, V. (2004) · PubMed · Cited by 85 · see citing works
Pro- and anti-apoptotic CD95 signaling in T cells
Paulsen, M., & Janßen, O. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-7 · Cited by 84 · see citing works
Zhao, M., Kiernan, C. H., Stairiker, C. J., Hope, J. L., León, L. G., van Meurs, M., Brouwers-Haspels, I., Boers, R., Boers, J., Gribnau, J. H., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008555 · Cited by 79 · see citing works
Self-citationGaiha, G. D., McKim, K. J., Woods, M. W., Pertel, T., Rohrbach, J., Barteneva, N. S., Chin, C. R., Liu, D., Soghoian, D. Z., Cesa, K. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.011 · Cited by 76 · see citing works
Coinhibitory receptors and CD8 T cell exhaustion in chronic infections
Kuchroo, V. K., Anderson, A. C., & Petrovas, C. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000088 · Cited by 75 · see citing works
Trautmann, L., Mbitikon-Kobo, F. M., Goulet, J.-P., Peretz, Y., Shi, Y., van Grevenynghe, J., Procopio, F. A., Boulassel, M. R., Routy, J., Chomont, N., et al. (2012) · Blood · doi:10.1182/blood-2012-04-422550 · Cited by 74 · see citing works
Xu, X., Screaton, G. R., & McMichael, A. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00255-2 · Cited by 73 · see citing works
Expansion of activated human naïve T-cells precedes effector function
Brenchley, J. M., Douek, D. C., Ambrozak, D. R., Chatterji, M., Betts, M. R., Davis, L. S., & Koup, R. A. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.02015.x · Cited by 71 · see citing works
Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 65 · see citing works
Maldonado, A., Mueller, Y. M., Thomas, P., Bojczuk, P. M., O'Connors, C., & Katsikis, P. D. (2003) · Arthritis Research & Therapy · doi:10.1186/ar619 · Cited by 65 · see citing works
Self-citationVasconcelos, J. R., Bruña–Romero, O., Araújo, A. F., Dominguez, M. R., Ersching, J., de Alencar, B. C., Machado, A. V., Gazzinelli, R. T., Bortoluci, K. R., Amarante-Mendes, G. P., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002699 · Cited by 64 · see citing works
Tussey, L., Nair, U. S., Bachinsky, M., Edwards, B. H., Bakari, J., Grimm, K. M., Joyce, J. G., Vessey, R., Steigbigel, R. T., Robertson, M. N., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/367707 · Cited by 64 · see citing works
Preferential Apoptosis of HIV-1-Specific CD4+ T Cells
Yue, F. Y., Kovacs, C. M., Dimayuga, R. C., Gu, X. X. J., Parks, P., Kaul, R., & Ostrowski, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2196 · Cited by 64 · see citing works
Mueller, Y. M. (2002) · International Immunology · doi:10.1093/intimm/dxg013 · Cited by 62 · see citing works
Self-citationChun, T., Justement, J. S., Sanford, C., Hallahan, C. W., Planta, M. A., Loutfy, M. R., Kottilil, S., Moir, S. L., Kovacs, C. M., & Fauci, A. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307328101 · Cited by 60 · see citing works
Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies
Ta, T. M., Malik, S., Anderson, E. M., Jones, A. D., Perchik, J., Freylikh, M., Sardo, L., Klase, Z. A., & Izumi, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.862270 · Cited by 57 · see citing works
Hurtrel, B., Petit, F., Arnoult, D., Müller-Trutwin, M. C., Silvestri, G., & Estaquier, J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401600 · Cited by 60 · see citing works
HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis
Laforge, M., Campillo-Gimenez, L., Monceaux, V., Cumont, M., Hurtrel, B., Corbeil, J., Zaunders, J. J., Elbim, C., & Estaquier, J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002087 · Cited by 58 · see citing works
HIV-Specific CD8+ T Cells Exhibit Markedly Reduced Levels of Bcl-2 and Bcl-xL
Petrovas, C., Mueller, Y. M., Dimitriou, I. D., Bojczuk, P. M., Mounzer, K., Witek, J., Altman, J. D., & Katsikis, P. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4444 · Cited by 58 · see citing works
Self-citationArnoult, D., Petit, F., Lelièvie, J. D., Lecossier, D., Hance, A. J., Monceaux, V., Fang, R. H. T., Huntrel, B., Ameisen, J., & Estaquier, J. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401289 · Cited by 62 · see citing works
The multiple roles of Fas ligand in the pathogenesis of infectious diseases
Dockrell, D. H. (2003) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2003.00669.x · Cited by 56 · see citing works
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation
Muthumani, K., Choo, A. Y., Hwang, D. S., Arumugam, P., Dayes, N. S., Harris, C. A., Green, D. R., Wadsworth, S. A., Siekierka, J. J., & Weiner, D. B. (2005) · Blood · doi:10.1182/blood-2005-03-0932 · Cited by 53 · see citing works
HIV-1 and IL-1β regulate Fas ligand expression in human astrocytes through the NF-κB pathway
Ghorpade, A., Hölter, S. M., Borgmann, K., Persidsky, R., & Wu, L. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00222-4 · Cited by 51 · see citing works
Wentink, M., Mueller, Y. M., Dalm, V., Driessen, G., van Hagen, P. V., van Montfrans, J. V., van der Burg, M., & Katsikis, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00446 · Cited by 48 · see citing works
Self-citationIncreased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells
Petrovas, C., Mueller, Y. M., Dimitriou, I. D., Altork, S. R., Banerjee, A., Sklar, P. A., Mounzer, K., Altman, J. D., & Katsikis, P. D. (2006) · Blood · doi:10.1182/blood-2006-05-021626 · Cited by 50 · see citing works
Self-citationT cell toxicity of HIV latency reversing agents
Zhao, M., Crignis, E. D., Rokx, C., Verbon, A., van Gelder, T., Mahmoudi, T., Katsikis, P. D., & Mueller, Y. M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.023 · Cited by 48 · see citing works
Self-citationGenescà, M., Rourke, T., Li, J., Bost, K., Chohan, B., McChesney, M. B., & Miller, C. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4732 · Cited by 47 · see citing works
Nasi, M., Pinti, M., Bugarini, R., Troiano, L., Lugli, E., Bellodi, C., Mussini, C., Borghi, V., Trenti, T., Balli, F., et al. (2005) · Immunogenetics · doi:10.1007/s00251-005-0031-z · Cited by 45 · see citing works
HIV-Specific CD8+T Cells from Elite Controllers Are Primed for Survival
Yan, J., Sabbaj, S., Bansal, A., Amatya, N., Shacka, J. J., Goepfert, P., & Heath, S. L. (2013) · Journal of Virology · doi:10.1128/jvi.02379-12 · Cited by 43 · see citing works
Quarter Century of Anti-HIV CAR T Cells
Wagner, T. A. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0388-x · Cited by 42 · see citing works
T-Cell Signaling in HIV-1 Infection
Abbas, W., & Herbein, G. (2013) · The Open Virology Journal · doi:10.2174/1874357920130621001 · Cited by 38 · see citing works
Tumor Necrosis Factor Receptor/Tumor Necrosis Factor Family Members in Antiviral CD8 T-Cell Immunity
Salek‐Ardakani, S., & Croft, M. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0026 · Cited by 41 · see citing works
Quaranta, M. G., Mattioli, B., Giordani, L., & Viora, M. (2004) · The FASEB Journal · doi:10.1096/fj.04-1633fje · Cited by 41 · see citing works
Monceaux, V., Viollet, L., Petit, F., Fang, R. H. T., Cumont, M., Zaunders, J. J., Hurtrel, B., & Estaquier, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6898 · Cited by 40 · see citing works
FAS mediates apoptosis, inflammation, and treatment of pathogen infection
Hu, L., Lu, J., Fan, H., Niu, C., Han, Y., Caiyin, Q., Wu, H., & Qiao, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1561102 · Cited by 38 · see citing works
The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS
Quaranta, M. G., Mattioli, B., Giordani, L., & Viora, M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6260rev · Cited by 39 · see citing works
HIV-associated memory B cell perturbations
Hu, Z., Luo, Z., Wan, Z., Wu, H., Li, W., Zhang, T., & Jiang, W. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.04.008 · Cited by 36 · see citing works
Quantitative studies of CD8+ T-cell responses during microbial infection
Serbina, N. V., & Pamer, E. G. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00071-2 · Cited by 35 · see citing works
Mojumdar, K., Vajpayee, M., Chauhan, N. K., Singh, A., Singh, R., & Kurapati, S. (2011) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20610 · Cited by 34 · see citing works
HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T Cells
Prévost, J., Edgar, C. R., Richard, J., Trothen, S. M., Jacob, R. A., Mumby, M. J., Pickering, S., Dubé, M., Kaufmann, D., Kirchhoff, F., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01999-19 · Cited by 33 · see citing works
Intrinsic and extrinsic pathways signaling during HIV-1 mediated cell death
Petit, F., Arnoult, D., Viollet, L., & Estaquier, J. (2003) · Biochimie · doi:10.1016/j.biochi.2003.09.007 · Cited by 32 · see citing works
The CD8 + T Cell Noncytotoxic Antiviral Responses
Morvan, M. G., Teque, F., Locher, C. P., & Levy, J. A. (2021) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00155-20 · Cited by 33 · see citing works
Kim, N., Dabrowska, A., Jenner, R. G., & Aldovini, A. (2007) · Journal of Virology · doi:10.1128/jvi.02616-06 · Cited by 31 · see citing works
Interleukin 7 Increases Human Immunodeficiency Virus Type 1 LAI-Mediated Fas-Induced T-Cell Death
Lelièvre, J., Petit, F., Arnoult, D., Ameisen, J., & Estaquier, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3195-3199.2005 · Cited by 30 · see citing works
T-CELL AND NEURONAL APOPTOSIS IN HIV INFECTION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION
Régulier, E. G., K, R., Khalili, K., Amini, S., Rappaport, J., Zagury, J., & Katsikis, P. D. (2004) · International Reviews of Immunology · doi:10.1080/08830180490265538 · Cited by 30 · see citing works
Self-citationTNF-α Controls Intrahepatic T Cell Apoptosis and Peripheral T Cell Numbers
Murray, D. A., & Crispe, I. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2402 · Cited by 29 · see citing works
Shasha, D., Karel, D., Angiuli, O., Greenblatt, A., Ghebremichael, M. S., Yu, X. G., Porichis, F., & Walker, B. D. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0915-422r · Cited by 28 · see citing works
Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy
Petrovas, C., Mueller, Y. M., & Katsikis, P. D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401595 · Cited by 28 · see citing works
Self-citationLelièvre, J., Mammano, F., Arnoult, D., Petit, F., Grodet, A., Estaquier, J., & Ameisen, J. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401441 · Cited by 23 · see citing works
Slyker, J. A., John-Stewart, G. C., Dong, T., Lohman-Payne, B. L., Reilly, M., Atzberger, A., Taylor, S., Maleche‐Obimbo, E., Mbori‐Ngacha, D., & Rowland‐Jones, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020375 · Cited by 21 · see citing works
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure
Viganó, S., Bobisse, S., Coukos, G., Perreau, M., & Harari, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01350 · Cited by 20 · see citing works
Insights Into the Pathophysiology of Liver Disease in HCV/HIV: Does it End With HCV Cure?
Jeyarajan, A. J., & Chung, R. T. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa279 · Cited by 20 · see citing works
Loucif, H., Dagenais-Lussier, X., Beji, C., Cassin, L., Jrade, H., Tellitchenko, R., Routy, J., Olagnier, D. P., & van Grevenynghe, J. (2021) · Autophagy · doi:10.1080/15548627.2021.1874134 · Cited by 20 · see citing works
Lara‐Aguilar, V., Llamas-Adán, M., Brochado‐Kith, O., Crespo‐Bermejo, C., Grande‐García, S., Arca-Lafuente, S., Santos, I. D. L., PRADO, C. M. C. O., Alía, M., Sainz-Pinós, C., et al. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01064-z · Cited by 17 · see citing works
Behrens, N. E., Wertheimer, A. M., Klotz, S. A., & Ahmad, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199101 · Cited by 16 · see citing works
Snyder-Cappione, J. E., Divekar, A., Maupin, G. M., Jin, X., Demeter, L. M., & Mosmann, T. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2662 · Cited by 17 · see citing works
Tarkowski, M., Ferraris, L., Martone, S., de Castilla, F. S., Misciagna, D., Mazzucchelli, R. I., Lattuada, E., Paraninfo, G., Galli, M., & Riva, A. (2011) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2010.0317 · Cited by 17 · see citing works
Apoptosis of CD57+ and CD57− lymphocytes in the lung and blood of HIV-infected subjects
Wood, K. L., Knox, K. S., Wang, Y., Day, R. B., Schnizlein-Bick, C. T., & Twigg, H. L. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.09.009 · Cited by 17 · see citing works
Sanctuaire du virus de l’immunodéficience humaine et mécanismes d’échappement
Estaquier, J., & Hurtrel, B. (2008) · médecine/sciences · doi:10.1051/medsci/200824121055 · Cited by 16 · see citing works
Aquaro, S., Ronga, L., Pollicita, M., Antinori, A., Ranazzi, A., & Perno, C. F. (2005) · Journal of NeuroVirology · doi:10.1080/13550280500513416 · Cited by 16 · see citing works
- Authors
- Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D.
- Affiliations
- Hahnemann University Hospital (US)
- National Institutes of Health (US)
- Emory University (US)
- Corresponding author
- Katsikis, Peter D
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 15
- Issue
- 6
- Pages
- 871-882
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2044870374
- Cited by
- 164
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI46719, R01AI046719)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- HIV-specific CD8+ T cells, Fas ligand, T cell survival, T cell differentiation, effector memory T cells, CD45RA, L-selectin, cytotoxicity, IFN-gamma production, HIV infection, cytotoxic T lymphocytes
- MeSH terms
- Adult, Cell Differentiation, Cytomegalovirus, Cytotoxicity, Immunologic, Herpesvirus 4, Human, HIV, Humans, Immunologic Memory, Interferon-gamma, Macrophages, T-Lymphocytes, Cytotoxic, HIV Infections, Immunophenotyping, T-Lymphocyte Subsets, Apoptosis, Leukocyte Common Antigens, Coculture Techniques, fas Receptor, L-Selectin, Viral Load
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review