The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Local calcium transients triggered by single L-type calcium channel currents in cardiac cells
Open accessAbstract
Excitation-contraction coupling was studied in mammalian cardiac cells in which the opening probability of L-type calcium (Ca2+) channels was reduced. Confocal microscopy during voltage-clamp depolarization revealed distinct local transients in the concentration of intracellular calcium ions ([Ca2+]i). When voltage was varied, the latency to occurrence and the relative probability of occurrence of local [Ca2+]i transients varied as predicted if Ca2+ release from the sarcoplasmic reticulum (SR) was linked tightly to Ca2+ flux through L-type Ca2+ channels but not to that through the Na-Ca exchanger or to average [Ca2+]i. Voltage had no effect on the amplitude of local [Ca2+]i transients. Thus, the most efficacious "Ca2+ signal" for activating Ca2+ release from the SR may be a transient microdomain of high [Ca2+]i beneath an individual, open L-type Ca2+ channel.
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Cites
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
Cheng, H., Lederer, W. J., & Cannell, M. B. (1993) · Science · doi:10.1126/science.8235594 · Cited by 1,935
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
McDonald, T. F., Pelzer, S., Trautwein, W., & Pelzer, D. J. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.365 · Cited by 995
Fabiato, A. (1985) · The Journal of general physiology · doi:10.1085/jgp.85.2.247 · Cited by 892
Theory of excitation-contraction coupling in cardiac muscle
Stern, M. D. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81615-6 · Cited by 651
Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum
Leblanc, N., & Hume, J. R. (1990) · Science · doi:10.1126/science.2158146 · Cited by 554
Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes
Näbauer, M., Callewaert, G., Cleemann, L., & Morad, M. (1989) · Science · doi:10.1126/science.2543067 · Cited by 453
Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes
Cannell, M. B., Cheng, H., & Lederer, W. J. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80677-0 · Cited by 361
Effect of Membrane Potential Changes on the Calcium Transient in Single Rat Cardiac Muscle Cells
Cannell, M. B., Berlin, J. R., & Lederer, W. J. (1987) · Science · doi:10.1126/science.2446391 · Cited by 353
Ryanodine Receptor Adaptation: Control Mechanism of Ca 2+ -Induced Ca 2+ Release in Heart
Györke, S., & Fill, M. (1993) · Science · doi:10.1126/science.8387229 · Cited by 325
Sodium-Calcium Exchange in Excitable Cells: Fuzzy Space
Lederer, W. J., Niggli, E., & Hadley, R. W. (1990) · Science · doi:10.1126/science.2326638 · Cited by 310
Cited by
Cardiac excitation–contraction coupling
Bers, D. M. (2002) · Nature · doi:10.1038/415198a · Cited by 4,744
Elementary and global aspects of calcium signalling.
Berridge, M. J. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021927 · Cited by 1,018
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758
The elemental principles of calcium signaling
Bootman, M. D., & Berridge, M. J. (1995) · Cell · doi:10.1016/0092-8674(95)90179-5 · Cited by 454
JAGGAR, WELLMAN, HEPPNER, PORTER, PEREZ, GOLLASCH, KLEPPISCH, RUBART, STEVENSON, LEDERER, et al. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.00462.x · Cited by 302
Metadata
- Authors
- Lopez-Lopez, Shacklock, P., Balke, C., & Wier, W.
- Venue
- Science
- Published
- 1995-05-19
- Volume
- 268
- Issue
- 5213
- Pages
- 1042-1045
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069230499
- Cited by
- 454
- References
- 12
- FWCI
- 32.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Lopez-Lopez, Shacklock, P., Balke, C., & Wier, W. (1995). Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science. https://doi.org/10.1126/science.7754383
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
