The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences
Abstract
Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear envelope followed by translocation through the nuclear pore. A recombinant human protein, hSRP1 alpha, bound in vitro specifically and directly to substrates containing either a simple or bipartite NLS motif. hSRP1 alpha promoted docking of import substrates to the nuclear envelope and together with recombinant human Ran reconstituted complete nuclear protein import. Thus, hSRP1 alpha has the properties of a cytosolic receptor for both simple and bipartite NLS motifs.
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Cites
Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein
Cuomo, C. A., Kirch, S. A., Gyuris, J., Brent, R., & Oettinger, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6156 · Cited by 164
Cited by
Nucleocytoplasmic transport: the soluble phase
Mattaj, I. W., & Englmeier, L. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.265 · Cited by 1,175
Self-citationDistinct functions for the two importin subunits in nuclear protein import
Görlich, D., Vogel, F., Mills, A. D., Hartmann, E., & Laskey, R. A. (1995) · Nature · doi:10.1038/377246a0 · Cited by 474
Fagotto, F., Glück, U., & Gumbiner, B. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70082-x · Cited by 434
Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor
Ikuta, T., Eguchi, H., Tachibana, T., Yoneda, Y., & Kawajiri, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2895 · Cited by 287
Köhler, M., Ansieau, S., Prehn, S., Leutz, A., Haller, H., & Hartmann, E. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01265-9 · Cited by 228
Metadata
- Authors
- Weis, K., Mattaj, I., & Lamond, A.
- Venue
- Science
- Published
- 1995-05-19
- Volume
- 268
- Issue
- 5213
- Pages
- 1049-1053
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1973731625
- Cited by
- 333
- References
- 1
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weis, K., Mattaj, I., & Lamond, A. (1995). Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science. https://doi.org/10.1126/science.7754385
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.