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A Subset of CD4 + Thymocytes Selected by MHC Class I Molecules
Abstract
To complete their maturation, most immature thymocytes depend on the simultaneous engagement of their antigen receptor [αβ T cell receptor (TCR)] and their CD4 or CD8 coreceptors with major histocompatibility complex class II or I ligands, respectively. However, a normal subset of mature αβ TCR+ thymocytes did not follow these rules. These thymocytes expressed NK1.1 and a restricted set of αβ TCRs that are intrinsically class I-reactive because their positive selection was class I-dependent but CD8-independent. These cells were CD4 + and CD4 - 8 - but never CD8 + , because the presence of CD8 caused negative selection. Thus, neither CD4 nor CD8 contributes signals that direct their maturation into the CD4 + and CD4 - 8 - lineages.
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Citations
Cited by
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Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar-Mather, T. P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.189 · Cited by 2,113
CD1 Recognition by Mouse NK1 + T Lymphocytes
Bendelac, A., Lantz, O., Quimby, M. E., Yewdell, J. W., Bennink, J. R., & Brutkiewicz, R. R. (1995) · Science · doi:10.1126/science.7538697 · Cited by 914
Self-citationNKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
Terabe, M., Matsui, S., Noben-Trauth, N., Chen, H., Watson, C., Donaldson, D. D., Carbone, D. P., Paul, W. E., & Berzofsky, J. A. (2000) · Nature Immunology · doi:10.1038/82771 · Cited by 699
Tilloy, F., Treiner, E., Park, S.-H., Garcia, C., Lemonnier, F., de la Salle, H., Bendelac, A., Bonneville, M., & Lantz, O. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1907 · Cited by 615
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Metadata
- Authors
- Bendelac, A., Killeen, N., Littman, D. R., & Schwartz, R. H.
- Venue
- Science
- Published
- 1994-03-25
- Volume
- 263
- Issue
- 5154
- Pages
- 1774-1778
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978757502
- Cited by
- 460
- References
- 0
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bendelac, A., Killeen, N., Littman, D. R., & Schwartz, R. H. (1994). A Subset of CD4 + Thymocytes Selected by MHC Class I Molecules. Science. https://doi.org/10.1126/science.7907820
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
