The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Convergent Pathways for Steroid Hormone- and Neurotransmitter-Induced Rat Sexual Behavior
Abstract
Estrogen and progesterone modulate gene expression in rodents by activation of intracellular receptors in the hypothalamus, which regulate neuronal networks that control female sexual behavior. However, the neurotransmitter dopamine has been shown to activate certain steroid receptors in a ligand-independent manner. A dopamine receptor stimulant and a D 1 receptor agonist, but not a D 2 receptor agonist, mimicked the effects of progesterone in facilitating sexual behavior in female rats. The facilitatory effect of the neurotransmitter was blocked by progesterone receptor antagonists, a D 1 receptor antagonist, or antisense oligonucleotides to the progesterone receptor. The results suggest that in rodents neurotransmitters may regulate in vivo gene expression and behavior by means of cross-talk with steroid receptors in the brain.
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Cited by
Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids
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Strategies and Methods for Research on Sex Differences in Brain and Behavior
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Self-citationMenstrual cycle phase modulates reward-related neural function in women
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Metadata
- Authors
- Mani, S. K., Allen, J. M. C., Clark, J. H., Blaustein, J. D., & O'Malley, B. W.
- Venue
- Science
- Published
- 1994-08-26
- Volume
- 265
- Issue
- 5176
- Pages
- 1246-1249
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085993193
- Cited by
- 326
- References
- 41
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mani, S. K., Allen, J. M. C., Clark, J. H., Blaustein, J. D., & O'Malley, B. W. (1994). Convergent Pathways for Steroid Hormone- and Neurotransmitter-Induced Rat Sexual Behavior. Science. https://doi.org/10.1126/science.7915049
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
