The DOI matches its Crossref record.
Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells
Abstract
Indirect evidence implicates γδ T cells in the cross-regulation of CD4 αβ T cell responses. Adoptive transfer of small numbers of γδ T cells from ovalbumin (OVA)-tolerant mice selectively suppressed T H 2 -dependent immunoglobulin E(IgE) antibody production without affecting parallel IgG responses. Challenge of these γδ T cells in vitro with specific antigen resulted in production of high levels of interferon γ. The effects of the γδ T cells may be mediated by direct inhibition of OVA-specific CD4 + T H 2 cell proliferation or selection for specific CD4 T H 2 cells.
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Cited by
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Bonneville, M., O'Brien, R. L., & Born, W. K. (2010) · Nature Reviews Immunology · doi:10.1038/nri2781 · Cited by 952
de Heer, H. J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M. A. M., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040035 · Cited by 785
Oral tolerance: immune mechanisms and treatment of autoimmune diseases
Weiner, H. L. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01053-0 · Cited by 731
Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
Hammad, H., & Lambrecht, B. N. (2008) · Nature Reviews Immunology · doi:10.1038/nri2275 · Cited by 666
γδ T cells in tissue physiology and surveillance
Ribot, J. C., Lopes, N., & Silva-Santos, B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00452-4 · Cited by 532
Metadata
- Authors
- McMenamin, C., Pimm, C., McKersey, M., & Holt, P. G.
- Venue
- Science
- Published
- 1994-09-23
- Volume
- 265
- Issue
- 5180
- Pages
- 1869-1871
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051579898
- Cited by
- 397
- References
- 0
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- McMenamin, C., Pimm, C., McKersey, M., & Holt, P. G. (1994). Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells. Science. https://doi.org/10.1126/science.7916481
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
