The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Kinetic Intermediates in RNA Folding
Abstract
The folding pathways of large, highly structured RNA molecules are largely unexplored. Insight into both the kinetics of folding and the presence of intermediates was provided in a study of the Mg 2+ -induced folding of the Tetrahymena ribozyme by hybridization of complementary oligodeoxynucleotide probes. This RNA folds via a complex mechanism involving both Mg 2+ -dependent and Mg 2+ -independent steps. A hierarchical model for the folding pathway is proposed in which formation of one helical domain (P4-P6) precedes that of a second helical domain (P3-P7). The overall rate-limiting step is formation of P3-P7, and takes place with an observed rate constant of 0.72 ± 0.14 minute -1 . The folding mechanism of large RNAs appears similar to that of many multidomain proteins in that formation of independently stable substructures precedes their association into the final conformation.
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Cites
Dominant forces in protein folding
Dill, K. A. (1990) · Biochemistry · doi:10.1021/bi00483a001 · Cited by 3,800
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Ribozymes: A Distinct Class of Metalloenzymes
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Visualizing the Higher Order Folding of a Catalytic RNA Molecule
Celander, D. W., & Cech, T. R. (1991) · Science · doi:10.1126/science.1989074 · Cited by 352
Model for the three-dimensional folding of 16 S ribosomal RNA
Stern, S., Weiser, B., & Noller, H. F. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90588-8 · Cited by 304
The molecular mechanism of thermal unfolding of Escherichia coli formylmethionine transfer RNA
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Cited by
Targeting RNA structures with small molecules
Childs-Disney, J. L., Yang, X., Gibaut, Q. M. R., Tong, Y., Batey, R. T., & Disney, M. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00521-4 · Cited by 587
Complex RNA Folding Kinetics Revealed by Single-Molecule FRET and Hidden Markov Models
Keller, B. G., Kobitski, A., Jäschke, A., Nienhaus, G. U., & Noé, F. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098719 · Cited by 84
Toward predicting self-splicing and protein-facilitated splicing of group I introns
Vicens, Q., Paukstelis, P. J., Westhof, E., Lambowitz, A. M., & Cech, T. R. (2008) · RNA · doi:10.1261/rna.1027208 · Cited by 49
Characterization of Tertiary Folding of RNA by Circular Dichroism and Urea
Sosnick, T. R. (2001) · Current Protocols in Nucleic Acid Chemistry · doi:10.1002/0471142700.nc1105s04 · Cited by 30
Functional characterization of dynamic nascent RNA folding ensembles in real time
Gor, K., Geissen, E. M., & Duss, O. (2026) · Science Advances · doi:10.1126/sciadv.aec4037 · Cited by 4
Metadata
- Authors
- Zarrinkar, P. P., & Williamson, J. R.
- Venue
- Science
- Published
- 1994-08-12
- Volume
- 265
- Issue
- 5174
- Pages
- 918-924
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969476076
- Cited by
- 306
- References
- 33
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
