The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Replacement of Diseased Mouse Liver by Hepatic Cell Transplantation
Abstract
Adult liver has the unusual ability to fully regenerate after injury. Although regeneration is accomplished by the division of mature hepatocytes, the replicative potential of these cells is unknown. Here, the replicative capacity of adult liver cells and their medical usefulness as donor cells for transplantation were investigated by transfer of adult mouse liver cells into transgenic mice that display an endogenous defect in hepatic growth potential and function. The transplanted liver cell populations replaced up to 80 percent of the diseased recipient liver. These findings demonstrate the enormous growth potential of adult hepatocytes, indicating the feasibility of liver cell transplantation as a method to replace lost or diseased hepatic parenchyma.
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Citations
Cites
Liver regeneration: molecular mechanisms of growth control
Michalopoulos, G. K. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.2.2404819 · Cited by 897
Hepatology. A Textbook of Liver Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-259_2 · Cited by 621
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
Sandgren, E. P., Palmiter, R. D., Heckel, J. L., Daugherty, C. C., Brinster, R. L., & Degen, J. L. (1991) · Cell · doi:10.1016/0092-8674(91)90615-6 · Cited by 392
Self-citationPalmiter, R. D., Chen, H. Y., & Brinster, R. L. (1982) · Cell · doi:10.1016/0092-8674(82)90186-6 · Cited by 369
Self-citationPonder, K. P., Gupta, S., Leland, F., Darlington, G., Finegold, M., DeMayo, J., Ledley, F. D., Chowdhury, J. R., & Woo, S. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1217 · Cited by 369
Sell, S. (1990) · PubMed · Cited by 296
Mercer, E. H., Hoyle, G. W., Kapur, R. P., Brinster, R. L., & Palmiter, R. D. (1991) · Neuron · doi:10.1016/0896-6273(91)90274-4 · Cited by 247
Self-citationKay, M. A., Baley, P., Rothenberg, S., Leland, F., Fleming, L., Ponder, K. P., Liu, T., Finegold, M., Darlington, G., & Pokorny, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.89 · Cited by 245
Palmiter, R. D., Sandgren, E. P., Koeller, D. M., & Brinster, R. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5266 · Cited by 209
Self-citationPancreatic tumor pathogenesis reflects the causative genetic lesion.
Sandgren, E. P., Quaife, C. J., Paulovich, A. G., Palmiter, R. D., & Brinster, R. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.93 · Cited by 156
Self-citation
Cited by
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Seeger, C., & Mason, W. S. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.1.51-68.2000 · Cited by 1,451
Fausto, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80412-2 · Cited by 1,022
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720
The role of hepatocytes and oval cells in liver regeneration and repopulation
Fausto, N., & Campbell, J. S. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00338-6 · Cited by 648
Metadata
- Authors
- Rhim, J. A., Sandgren, E. P., Degen, J. L., Palmiter, R. D., & Brinster, R. L.
- Venue
- Science
- Published
- 1994-02-25
- Volume
- 263
- Issue
- 5150
- Pages
- 1149-1152
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068764558
- Cited by
- 577
- References
- 11
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rhim, J. A., Sandgren, E. P., Degen, J. L., Palmiter, R. D., & Brinster, R. L. (1994). Replacement of Diseased Mouse Liver by Hepatic Cell Transplantation. Science. https://doi.org/10.1126/science.8108734
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
