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Block in Nuclear Localization of period Protein by a Second Clock Mutation, timeless
Abstract
In wild-type Drosophila , the period protein (PER) is found in nuclei of the eyes and brain, and PER immunoreactivity oscillates with a circadian rhythm. The studies described here indicate that the nuclear localization of PER is blocked by timeless ( tim ), a second chromosome mutation that, like per null mutations, abolishes circadian rhythms. PER fusion proteins without a conserved domain (PAS) and some flanking sequences are nuclear in tim mutants. This suggests that a segment of PER inhibits nuclear localization in tim mutants. The tim gene may have a role in establishing rhythms of PER abundance and nuclear localization in wild-type flies.
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Cited by
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Circadian oscillation of a mammalian homologue of the Drosophila period gene
Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., & Sakaki, Y. (1997) · Nature · doi:10.1038/39086 · Cited by 792
Lee, S. B., Bae, I. H., Bae, Y. S., & Um, H.-D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606702200 · Cited by 187
Van Laake, L. W., Lüscher, T. F., & Young, M. E. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx775 · Cited by 74
Self-citationKaiser, T. S., & Heckel, D. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032092 · Cited by 37
Metadata
- Authors
- Vosshall, L. B., Price, J. L., Sehgal, A., Saez, L., & Young, M. W.
- Venue
- Science
- Published
- 1994-03-18
- Volume
- 263
- Issue
- 5153
- Pages
- 1606-1609
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968410906
- Cited by
- 377
- References
- 0
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Block in Nuclear Localization of period Protein by a Second Clock Mutation, timeless. https://app.cochat.ai/papers/10.1126/science.8128247
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- Vosshall, L. B., Price, J. L., Sehgal, A., Saez, L., & Young, M. W. (1994). Block in Nuclear Localization of period Protein by a Second Clock Mutation, timeless. Science. https://doi.org/10.1126/science.8128247
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