Cited by 1,632Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

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Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

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Vitaterna, Martha Hotz, King, David P., Chang, Anne-Marie, Kornhauser, Jon M., Lowrey, Phillip L., McDonald, J. David, Dove, William F., Pinto, Lawrence H., Turek, Fred W., Takahashi, Joseph S.·1994·Science

DOI 10.1126/science.8171325PMC PMC3839659

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Abstract

In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.

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Authors: Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S.
Affiliations: Northwestern University (US)
University of Wisconsin–Madison (US)
ORCID: Vitaterna, Martha Hotz
Chang, Anne-Marie
Dove, William F.
Turek, Fred W.
Takahashi, Joseph S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1994-04-29
Volume: 264
Issue: 5159
Pages: 719-725
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8171325
PMC: PMC3839659
OpenAlex: W1992494470
Cited by: 1,632
References: 49
Citations by year: 2026: 17 · 2025: 53 · 2024: 41 · 2023: 39 · 2022: 47 · 2021: 50 · 2020: 58 · 2019: 42 · 2018: 59 · 2017: 57 · 2016: 51 · 2015: 53 · 2014: 66 · 2013: 62 · 2012: 50
FWCI: 22.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (5p30ca007175-36)
National Cancer Institute (P30 CA 07175)
National Institute on Deafness and Other Communication Disorders (T32DC000015)
National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK40493)
National Institute of Neurological Disorders and Stroke (T32 NS071040)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: clock genes, circadian rhythm, circadian activity, N-ethyl-N-nitrosourea mutagenesis, ENU mutagenesis, mouse chromosome 5, human chromosome 4, gene mapping, semi-dominant mutation, circadian period, behavioral genetics
MeSH terms: Animals, Chromosome Mapping, Chromosomes, Human, Pair 4, Circadian Rhythm, Ethylnitrosourea, Female, Genes, Genotype, Humans, Male, Mice, Inbred C57BL, Phenotype, Mutagenesis, Mice

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Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

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