The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Open accessAbstract
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The primary genetic model for examining linkage between the circadian and metabolic systems has been the Clock mutant mouse, in which the core circadian gene, Clock, is mutated such that the animal's endogenous circadian period is lengthened (47).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [47]
In the citing paper
“Genetic and biochemical evidence demonstrates that the bHLH-PAS protein CLOCK is required for the proper maintenance of circadian rhythms in mammals.”
From Mop3 is an essential component of the master circadian pacemaker in mammals. (2000) · cites this paper as Vitaterna et al. 1994
Citations
Cites
Lander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J., Lincoln, S. E., & Newberg, L. A. (1987) · Genomics · doi:10.1016/0888-7543(87)90010-3 · Cited by 6,657
Suprachiasmatic nucleus : the mind's clock
Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991) · Cited by 1,715
Exogenous and Endogenous Components in Circadian RhythmsPreprint
Aschoff, J. (1960) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1960.025.01.004 · Cited by 1,487
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
Hardin, P. E., Hall, J. C., & Rosbash, M. (1990) · Nature · doi:10.1038/343536a0 · Cited by 1,156
A genetic map of the mouse suitable for typing intraspecific crosses.
Dietrich, W., Katz, H., Lincoln, S. E., Shin, H., Friedman, J. M., Dracopoli, N. C., & Lander, E. S. (1992) · Genetics · doi:10.1093/genetics/131.2.423 · Cited by 1,080
The chi square periodogram: Its utility for analysis of circadian rhythms
Sokolove, P. G., & Bushell, W. N. (1978) · Journal of Theoretical Biology · doi:10.1016/0022-5193(78)90022-x · Cited by 972
A functional analysis of circadian pacemakers in nocturnal rodents
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417859 · Cited by 765
A Mutation of the Circadian System in Golden Hamsters
Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 697
Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency
Aronson, B. D., Johnson, K. A., Loros, J., & Dunlap, J. (1994) · Science · doi:10.1126/science.8128244 · Cited by 605
A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects
Copeland, N. G., Jenkins, N. A., Gilbert, D. J., Eppig, J. T., Maltais, L. J., Miller, J. C., Dietrich, W. F., Weaver, A., Lincoln, S. E., Steen, R. G., et al. (1993) · Science · doi:10.1126/science.8211130 · Cited by 546
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
Russell, W. L., Kelly, E. M., Hunsicker, P. R., Bangham, J. W., Maddux, S. C., & Phipps, E. L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5818 · Cited by 517
A Macintosh program for storage and analysis of experimental genetic mapping data
Manly, K. F. (1993) · Mammalian Genome · doi:10.1007/bf00357089 · Cited by 496
Positional cloning: Let's not call it reverse anymore
Collins, F. S. (1992) · Nature Genetics · doi:10.1038/ng0492-3 · Cited by 480
Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains
Schwartz, W., & Zimmerman, P. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03685.1990 · Cited by 315
Rusak, B. (1977) · Journal of Comparative Physiology A · doi:10.1007/bf00611819 · Cited by 248
Takahashi, J. S., Murakami, N., Nikaido, S. S., Pratt, B. L., & Robertson, L. M. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-571145-6.50010-8 · Cited by 244
HITOTSUMACHI, S., Carpenter, D. A., & Russell, W. L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.19.6619 · Cited by 235
Baylies, M. K., Bargiello, T. A., Jackson, F. R., & Young, M. W. (1987) · Nature · doi:10.1038/326390a0 · Cited by 231
Circadian oscillations in period gene mRNA levels are transcriptionally regulated.
Hardin, P. E., Hall, J. C., & Rosbash, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11711 · Cited by 218
Van Den Pol, A. N., & Powley, T. (1979) · Brain Research · doi:10.1016/0006-8993(79)90427-x · Cited by 216
Genetic Analysis of Circadian Clocks
Dunlap, J. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.003343 · Cited by 205
Circadian Rhythm in Membrane Conductance Expressed in Isolated Neurons
Michel, S. H., Geusz, M. E., Zaritsky, J. J., & Block, G. D. (1993) · Science · doi:10.1126/science.8421785 · Cited by 203
Ibuka, N., Inouye, S. T., & Kawamura, H. (1977) · Brain Research · doi:10.1016/0006-8993(77)90660-6 · Cited by 191
Molecular biology of circadian rhythms
Sehgal, A. (2004) · Cited by 180
Hamblen, M. J., Wheeler, D. A., Rutila, J. E., Rosbash, M., & Hall, J. C. (1992) · Journal of Insect Behavior · doi:10.1007/bf01058189 · Cited by 167
Phase Shifting of the Circadian Clock by Induction of the Drosophila period Protein
Edery, I., Rutila, J. E., & Rosbash, M. (1994) · Science · doi:10.1126/science.8284676 · Cited by 146
The molecular biology of circadian rhythms
Rosbash, M., & Hall, J. C. (1989) · Neuron · doi:10.1016/0896-6273(89)90199-2 · Cited by 126
Dowse, H. B., & Ringo, J. M. (1987) · Journal of Biological Rhythms · doi:10.1177/074873048700200106 · Cited by 115
Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila
Smith, R. F., & Konopka, R. J. (1982) · Molecular and General Genetics MGG · doi:10.1007/bf00333786 · Cited by 111
Gerkema, M. P., Groos, G. A., & Daan, S. (1990) · Journal of Biological Rhythms · doi:10.1177/074873049000500201 · Cited by 108
Chemical mutagenesis and fine-structure functional analysis of the mouse genome
Rinchik, E. M. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90016-j · Cited by 107
Gerkema, M. P., Daan, S., Wilbrink, M., Hop, M. W., & van der Leest, F. (1993) · Journal of Biological Rhythms · doi:10.1177/074873049300800205 · Cited by 104
Hall, J. C. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.003303 · Cited by 102
Circadian clock phenotypes of chromosome aberrations with a breakpoint at the per locus
Smith, R. F., & Konopka, R. J. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00270625 · Cited by 96
Development of the mouse circadian pacemaker: Independence from environmental cycles
Davis, F. C., & Menaker, M. (1981) · Journal of Comparative Physiology A · doi:10.1007/bf00609919 · Cited by 93
Circadian-clock regulation of gene expression
Takahashi, J. S. (1993) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(93)90038-q · Cited by 90
Induction of recessive lethal mutations in theT/t–H-2region of the mouse genome by a point mutagen
Shedlovsky, A. E., Guénet, J., Johnson, L. L., & Dove, W. F. (1986) · Genetics Research · doi:10.1017/s0016672300022977 · Cited by 88
Circadian Clock Genes Are Ticking
Takahashi, J. S. (1992) · Science · doi:10.1126/science.1384127 · Cited by 82
Strain differences of the mouse's free-running circadian rhythm in continuous darkness☆
Ebihara, S., TSUJI, K., & KONDO, K. (1978) · Physiology & Behavior · doi:10.1016/0031-9384(78)90308-6 · Cited by 63
Lesions of the suprachiasmatic nucleus disrupt circadian locomotor rhythms in the mouse
Schwartz, W. J., & Zimmerman, P. M. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90364-t · Cited by 60
Circadian rhythms: From gene expression to behavior
Takahashi, J. S. (1991) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(05)80028-5 · Cited by 58
Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster
Gailey, D. A., Villella, A., & Tully, T. (1991) · Journal of Comparative Physiology A · doi:10.1007/bf00194897 · Cited by 53
Silver, J. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901760409 · Cited by 43
Possidente, B. P., & Stephan, F. K. (1988) · Behavior Genetics · doi:10.1007/bf01067080 · Cited by 41
Scheuch, G. C., Johnson, W. A., Conner, R., & Silver, J. (1982) · Journal of Comparative Physiology A · doi:10.1007/bf00619149 · Cited by 24
Stochastic principles in the temporal control of activity behaviour.
Lehmann, U. (1977) · PubMed · Cited by 24
Gene differences modify Aschoff's rule in mice
Possidente, B. P., & Hegmann, J. P. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90126-3 · Cited by 23
Kozak, C. A., & Stephenson, D. A. (1993) · Mammalian Genome · doi:10.1007/bf00360831 · Cited by 17
Turek, F. W. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-571149-4.50007-6 · Cited by 14
Flagged first, then by citations
Research works printed but not linked: 5
- Aschoff, J., Handbook of Behavioral Neurobiology 4: 3 (1981).
- Enright, J. T., Handbook of Behavioral Neurobiology 4: 11 (1981).
- GAILEY, D. A., JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY 169: 685 (1991).
- LEHMANN, U, INTERNATIONAL JOURNAL OF CHRONOBIOLOGY 4: 223 (1976).
- TUREK, F. W., RECENT PROGRESS IN HORMONE RESEARCH, VOL 49 49: 43 (1994).
Cited by
Sorted by citations
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 2,035
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Metadata
- Authors
- Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S.
- Affiliations
- Northwestern University (US)
- University of Wisconsin–Madison (US)
- Venue
- Science
- Published
- 1994-04-29
- Volume
- 264
- Issue
- 5159
- Pages
- 719-725
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3839659
- OpenAlex
- W1992494470
- Cited by
- 1,632
- References
- 49
- Citations by year
- 2026: 17 · 2025: 53 · 2024: 41 · 2023: 39 · 2022: 47 · 2021: 50 · 2020: 58 · 2019: 42 · 2018: 59 · 2017: 57 · 2016: 51 · 2015: 53 · 2014: 66 · 2013: 62 · 2012: 50
- FWCI
- 22.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p30ca007175-36)
- National Cancer Institute (P30 CA 07175)
- National Institute on Deafness and Other Communication Disorders (T32DC000015)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK40493)
- National Institute of Neurological Disorders and Stroke (T32 NS071040)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- clock genes, circadian rhythm, circadian activity, N-ethyl-N-nitrosourea mutagenesis, ENU mutagenesis, mouse chromosome 5, human chromosome 4, gene mapping, semi-dominant mutation, circadian period, behavioral genetics
- MeSH terms
- Animals, Chromosome Mapping, Chromosomes, Human, Pair 4, Circadian Rhythm, Ethylnitrosourea, Female, Genes, Genotype, Humans, Male, Mice, Inbred C57BL, Phenotype, Mutagenesis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
