Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

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  1. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms
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  2. Alternative Initiation of Translation and Time-Specific Phosphorylation Yield Multiple Forms of the Essential Clock Protein FREQUENCY
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  3. Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes
    Katsutaka Oishi, Koyomi Miyazaki, Koji Kadota, Reiko F. Kikuno, Takahiro Nagase, Gen-ichi Atsumi, Naoki Ohkura, Takashi Azama, Miho Mesaki, Shima Yukimasa et al. · 2003 · Journal of Biological Chemistry
  4. Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription
    Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Alexander V. Gasparian, Natalia G. Fedtsova, Anatoli S. Gleiberman, Ilya I. Gitlin, Natalia M. Artemicheva, Krysta A. Deluca, Andrei V. Gudkov et al. · 2012 · Proceedings of the National Academy of Sciences
  5. Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and Timeless
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  6. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
    Vanja Pekovic‐Vaughan, Julie Elizabeth Gibbs, Hikari Yoshitane, Nan Yang, Dharshika RJ Pathiranage, Baoqiang Guo, Aya Sagami, Keiko Taguchi, David A. Bechtold, Andrew S. I. Loudon et al. · 2014 · Genes & Development
  7. Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight
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  8. Stopping Time: The Genetics of Fly and Mouse Circadian Clocks
    Ravi Allada, Patrick Emery, Joseph S. Takahashi, Michael Rosbash · 2001 · Annual Review of Neuroscience
  9. Circadian Clock Mutants of Cyanobacteria
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  10. The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior
    Luis Lopez‐Molina, François Conquet, Michel Dubois‐Dauphin, Ueli Schibler · 1997 · The EMBO Journal
  11. A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo
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  12. The suprachiasmatic nucleus and the circadian time-keeping system revisited
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  13. GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation
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  14. Chemical Genetics
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  15. Vascular Disease in Mice With a Dysfunctional Circadian Clock
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  16. CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor α (PPARα) in mice
    Katsutaka Oishi, Hidenori Shirai, Norio Ishida · 2005 · Biochemical Journal
  17. An Integrated View of Potassium Homeostasis
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  18. Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
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  20. A role for cryptochromesin sleep regulation
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  21. Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
    Hugues Dardente, Hugues Dardente, Nicolas Cermakian · 2007 · Chronobiology International
  22. Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei
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  23. High-Efficiency Nanoscale Liquid Chromatography Coupled On-Line with Mass Spectrometry Using Nanoelectrospray Ionization for Proteomics
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  24. The relationship between nutrition and circadian rhythms in mammals
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  25. Circadian rhythms in a nutshell
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  26. Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice
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  27. Neuronal Machinery of Sleep Homeostasis in Drosophila
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  28. Subfemtomole MS and MS/MS Peptide Sequence Analysis Using Nano-HPLC Micro-ESI Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
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  29. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
    Victoria Gorbacheva, Roman V. Kondratov, Renliang Zhang, Srujana Cherukuri, Andrei V. Gudkov, Joseph S. Takahashi, Marina P. Antoch · 2005 · Proceedings of the National Academy of Sciences
  30. Genetics and molecular biology of rhythms in Drosophila and other insects
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  31. Circadian clock-mediated regulation of blood pressure
    Lauren G. Douma, Michelle L. Gumz · 2017 · Free Radical Biology and Medicine
  32. The role of mPer2 clock gene in glucocorticoid and feeding rhythms
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  33. Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism
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  34. Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management
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  35. Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception
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  36. Antiphase Circadian Expression betweenBMAL1andperiodHomologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats
    Katsutaka Oishi, Katsuhiko Sakamoto, Tetsuya Okada, Takahiro Nagase, Norio Ishida · 1998 · Biochemical and Biophysical Research Communications
  37. Circadian clock regulates the host response to Salmonella
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  38. Circadian rhythms, metabolism, and chrononutrition in rodents and humans
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  39. Thermally Regulated Translational Control of FRQ Mediates Aspects of Temperature Responses in the Neurospora Circadian Clock
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  40. Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation
    Keith C. Summa, Robin M. Voigt, Christopher B. Forsyth, Maliha W. Shaikh, Kate E. Cavanaugh, Yueming Tang, Martha Hotz Vitaterna, Shiwen Song, Fred William Turek, Ali Keshavarzian · 2013 · PLoS ONE
  41. Cancer chronotherapy: Principles, applications, and perspectives
    Marie‐Christine Mormont, Françis Lévi · 2002 · Cancer
  42. Clock Genes in the Heart
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  43. Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior
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  44. Review: Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy
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  45. Circadian regulation of lipid mobilization in white adipose tissues
    Shostak, Anton, Meyer-Kovac, Judit, Oster, Henrik · 2013 · Diabetes
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  47. Trippings along the trail to the molecular mechanisms of biological clocks
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  48. Circadian regulation of melatonin production in cultured zebrafish pineal and retina
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  49. Biochemical and molecular studies using human autopsy brain tissue
    Matthew R. Hynd, Joanne M. Lewohl, Heather Louise Scott, Peter Ronald Dodd · 2003 · Journal of Neurochemistry
  50. Novel method for high-throughput phenotyping of sleep in mice
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  51. Genetics of circadian rhythms and sleep in human health and disease
    Lane, Jacqueline M., Qian, Jingyi, Mignot, Emmanuel, Redline, Susan, Scheer, Frank A. J. L., Saxena, Richa · 2023 · Nature Reviews Genetics
  52. Mammalian circadian clock and metabolism – the epigenetic link
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  56. The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
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  72. Association of the Length Polymorphism in the Human Per3 Gene with the Delayed Sleep-Phase Syndrome: Does Latitude Have an Influence Upon It?
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  74. Adaptive Significance of Circadian Clocks
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  81. Characterization of the Molecular Clock in Mouse Peritoneal Macrophages
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  84. Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
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  87. The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects
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  88. Circadian Variation of the Response of T Cells to Antigen
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  89. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1
    Irène Yujnovsky, Jun Hirayama, Masao Doi, Emiliana Borrelli, Paolo Sassone‐Corsi · 2006 · Proceedings of the National Academy of Sciences
  90. Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals
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  91. Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus
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  93. A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion
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  95. Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms
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  96. Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver
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  98. Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders
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  99. Diurnal Regulation of MTP and Plasma Triglyceride by CLOCK Is Mediated by SHP
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  100. Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
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