The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Abstract
Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early atherosclerosis. The present studies reveal that transgenic mice that overexpress mouse apoA-II had elevated HDL-cholesterol concentrations but, nevertheless, exhibited increased atherosclerotic lesion development as compared to normal mice. The HDL in the transgenic mice was larger and had an increased ratio of apoA-II to apoA-I. Thus, both the composition and amount of HDL appear to be important determinants of atherosclerosis.
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Cited by
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Variations in DNA elucidate molecular networks that cause disease
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Self-citation
Metadata
- Authors
- Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J.
- Venue
- Science
- Published
- 1993-07-23
- Volume
- 261
- Issue
- 5120
- Pages
- 469-472
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974976899
- Cited by
- 360
- References
- 28
- FWCI
- 39.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993). Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II. Science. https://doi.org/10.1126/science.8332912
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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