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wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo
Abstract
wingless/wnt-1 signaling directs cell fate during development. Genetic analysis in Drosophila identified genes that may encode components of the wingless signal transduction system. Drosophila Armadillo, homolog of vertebrate β-catenin, is required for wingless signaling. Unlike armadillo RNA, Armadillo protein accumulates non-uniformly in different cells of each embryonic segment. We found that cells alter their intracellular distribution of Armadillo in response to Wingless signal, accumulating increased levels of cytoplasmic Armadillo relative to those of membrane-associated protein. Levels of cytoplasmic Armadillo are also regulated by Zeste-White 3 kinase. Analysis of double mutants demonstrates that Armadillo’s role in wingless signaling is direct, and that Armadillo functions down-stream of both wingless and zeste-white 3. We present a model for the role of Armadillo stripes in transduction of wingless signal.
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Citations
Cited by
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Metadata
- Authors
- Peifer, M., Sweeton, D., Casey, M., & Wieschaus, E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-02-01
- Volume
- 120
- Issue
- 2
- Pages
- 369-380
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2472955934
- Cited by
- 426
- References
- 0
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. https://app.cochat.ai/papers/10.1242/dev.120.2.369
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- Peifer, M., Sweeton, D., Casey, M., & Wieschaus, E. (1994). wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development. https://doi.org/10.1242/dev.120.2.369
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