The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides
Abstract
The function of neuropeptide Y, one of the most abundant peptide transmitters of the mammalian brain, remains unclear because of a lack of specific receptor antagonists. An antisense oligodeoxynucleotide corresponding to the NH 2 -terminus of the rat Y1 receptor was constructed and added to cultures of rat cortical neurons. This treatment resulted in a reduced density of Y1 (but not Y2) receptors and diminished the decrease in adenosine 3′,5′-monophosphate (cAMP) usually seen after Y1 receptor activation. Repeated injection of the same oligodeoxynucleotide into the lateral cerebral ventricle of rats was followed by a similar reduction of cortical Y1 (but not Y2) receptors. Such antisense-treated animals displayed behavioral signs of anxiety. Thus, specific inhibition of neurotransmitter receptor expression can be accomplished in the living brain and demonstrates that altered central neuropeptide Y transmission produces an anxiety-like state.
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Cites
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Cited by
Smoking, stress, and negative affect: Correlation, causation, and context across stages of smoking.
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The neurobiology and control of anxious states
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The NPY system in stress, anxiety and depression
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Self-citation
Metadata
- Authors
- Wahlestedt, C., Pich, E. M., Koob, G. F., Yee, F., & Heilig, M.
- Venue
- Science
- Published
- 1993-01-22
- Volume
- 259
- Issue
- 5094
- Pages
- 528-531
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079803201
- Cited by
- 527
- References
- 30
- FWCI
- 17.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wahlestedt, C., Pich, E. M., Koob, G. F., Yee, F., & Heilig, M. (1993). Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides. Science. https://doi.org/10.1126/science.8380941
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
