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Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis
Abstract
Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo.
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Citations
Cited by
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
MEF2: a central regulator of diverse developmental programs
Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834
Self-citationCooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
Molkentin, J. D., Black, B. L., Martin, J. F., & Olson, E. N. (1995) · Cell · doi:10.1016/0092-8674(95)90139-6 · Cited by 819
Self-citationFirulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D., & Olson, E. N. (1998) · Nature Genetics · doi:10.1038/ng0398-266 · Cited by 386
Self-citationLu, M.-F., Cheng, H.-T., Kern, M. J., Potter, S. S., Tran, B., G. H. Diekwisch, T., & F. Martin, J. (1999) · Development · doi:10.1242/dev.126.3.495 · Cited by 136
Metadata
- Authors
- Cheng, T.-C., Wallace, M. C., Merlie, J. P., & Olson, E. N.
- Venue
- Science
- Published
- 1993-07-09
- Volume
- 261
- Issue
- 5118
- Pages
- 215-218
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066398820
- Cited by
- 254
- References
- 0
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, T.-C., Wallace, M. C., Merlie, J. P., & Olson, E. N. (1993). Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis. Science. https://doi.org/10.1126/science.8392225
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
