The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper
Abstract
The human and Drosophila heat shock transcription factors (HSFs) are multi-zipper proteins with high-affinity binding to DNA that is regulated by heat shock-induced trimerization. Formation of HSF trimers is dependent on hydrophobic heptad repeats located in the amino-terminal region of the protein. Two subregions at the carboxyl-terminal end of human HSF1 were identified that maintain the monomeric form of the protein under normal conditions. One of these contains a leucine zipper motif that is conserved between vertebrate and insect HSFs. These results suggest that the carboxyl-terminal zipper may suppress formation of trimers by the amino-terminal HSF zipper elements by means of intramolecular coiled-coil interactions that are sensitive to heat shock.
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Cites
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NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN
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Stress proteins in biology and medicine
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Cited by
Morimoto, R. I. (1998) · Genes & Development · doi:10.1101/gad.12.24.3788 · Cited by 1,906
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
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Heat shock factors: integrators of cell stress, development and lifespan
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Regulation of heat shock transcription factors and their roles in physiology and disease
Gomez-Pastor, R., Burchfiel, E. T., & Thiele, D. J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.73 · Cited by 849
Regulation of H SF 1 Function in the Heat Stress Response: Implications in Aging and Disease
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Metadata
- Authors
- Rabindran, S. K., Haroun, R. I., Clos, J., Wisniewski, J., & Wu, C.
- Venue
- Science
- Published
- 1993-01-08
- Volume
- 259
- Issue
- 5092
- Pages
- 230-234
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091477850
- Cited by
- 494
- References
- 31
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rabindran, S. K., Haroun, R. I., Clos, J., Wisniewski, J., & Wu, C. (1993). Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper. Science. https://doi.org/10.1126/science.8421783
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
