The DOI matches its Crossref record.
Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site
Abstract
The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins, including cytoskeletal elements and signaling proteins. It is believed that SH3 domains serve as modules that mediate protein-protein associations and, along with Src homology 2 (SH2) domains, regulate cytoplasmic signaling. The SH3 binding sites of two SH3 binding proteins were localized to a nine- or ten-amino acid stretch very rich in proline residues. Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor. Identification of the SH3 binding site provides a basis for understanding the interaction between the SH3 domains and their targets.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Rao, E., Weiss, B., Fukami, M., Rump, A., Niesler, B., Mertz, A., Muroya, K., Binder, G., Kirsch, S., Winkelmann, M., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-54 · Cited by 943
Modular binding domains in signal transduction proteins
Cohen, G. B., Ren, R., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90406-9 · Cited by 951
Self-citationC-type lectin receptors on dendritic cells and langerhans cells
Figdor, C. G., van Kooyk, Y., & Adema, G. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri723 · Cited by 842
Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799
Feng, S., Chen, J. K., Yu, H., Simon, J. A., & Schreiber, S. L. (1994) · Science · doi:10.1126/science.7526465 · Cited by 687
Chen, H. I., & Sudol, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7819 · Cited by 557
Woods, D. F., Hough, C., Peel, D., Callaini, G., & Bryant, P. J. (1996) · The Journal of cell biology · doi:10.1083/jcb.134.6.1469 · Cited by 417
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
Lioubin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, A., & Rohrschneider, L. R. (1996) · Genes & Development · doi:10.1101/gad.10.9.1084 · Cited by 418
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4806 · Cited by 397
Linear motifs: Evolutionary interaction switches
Neduva, V., & Russell, R. B. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.005 · Cited by 352
Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module
Salcini, A. E., Confalonieri, S., Doria, M., Santolini, E., Tassi, E., Minenkova, O., Cesareni, G., Pelicci, P. G., & Di Fiore, P. P. (1997) · Genes & Development · doi:10.1101/gad.11.17.2239 · Cited by 315
Wientjes, F. B., Hsuan, J. J., Totty, N. F., & Segal, A. W. (1993) · Biochemical Journal · doi:10.1042/bj2960557 · Cited by 301
Structure and function of the WW domain
Sudol, M. (1996) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(96)00008-9 · Cited by 296
PHOG, a candidate gene for involvement in the short stature of Turner syndrome
Ellison, J. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1341 · Cited by 286
Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains
Yamabhai, M., Hoffman, N. G., Hardison, N. L., McPherson, P. S., Castagnoli, L., Cesareni, G., & Kay, B. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31401 · Cited by 256
Hoskins, R., Hajnal, A. F., Harp, S. A., & Kim, S. K. (1996) · Development · doi:10.1242/dev.122.1.97 · Cited by 203
Lamarche, N., & Hall, A. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90114-7 · Cited by 196
Brown, S. D., Twells, R. C. J., Hey, P. J., Cox, R. D., Levy, E. R., Soderman, A. R., Metzker, M. L., Caskey, C. T., Todd, J. A., & Hess, J. F. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9061 · Cited by 176
Lock, L. S., Royal, I., Naujokas, M. A., & Park, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003597200 · Cited by 169
CD28: a signalling perspective
WARD, S. G. (1996) · Biochemical Journal · doi:10.1042/bj3180361 · Cited by 149
Komada, M., & Kitamura, N. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6213 · Cited by 149
Disabled-2 inactivation is an early step in ovarian tumorigenicity
Fazili, Z., Sun, W., Mittelstaedt, S., Cohen, C., & Xu, X.-X. (1999) · Oncogene · doi:10.1038/sj.onc.1202649 · Cited by 116
Leusen, J. H. W., Fluiter, K., Hilarius, P. M., Roos, D., Verhoeven, A. J., & Bolscher, B. G. J. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11216 · Cited by 76
Tseng, C.-P., Ely, B. D., Li, Y., Pong, R.-C., & Hsieh, J.-T. (1998) · Endocrinology · doi:10.1210/endo.139.8.6159 · Cited by 74
Malki, I., Cantrelle, F., Sottejeau, Y., Lippens, G., Lambert, J., & Landrieu, I. (2017) · The FEBS Journal · doi:10.1111/febs.14185 · Cited by 54
Kaneko, T., Kumasaka, T., Ganbe, T., Sato, T., Miyazawa, K., Kitamura, N., & Tanaka, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306677200 · Cited by 51
Kleeff, J., Huang, Y., Mok, S. C., Zimmermann, A., Friess, H., & Büchler, M. W. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6399-2 · Cited by 42
Metadata
- Authors
- Ren, R., Mayer, B. J., Cicchetti, P., & Baltimore, D.
- Venue
- Science
- Published
- 1993-02-19
- Volume
- 259
- Issue
- 5098
- Pages
- 1157-1161
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085140159
- Cited by
- 1,191
- References
- 0
- FWCI
- 56.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
