The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants
Abstract
Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions from DNA. The only known site-directed recombination process in vertebrates is the V(D)J recombination of lymphocyte antigen receptor genes. A large panel of cell lines deficient in DNA repair were tested for the ability to perform V(D)J recombination after introduction of the RAG-1 and RAG-2 genes. Two mutants failed to generate normal V(D)J recombination, and further analysis provided evidence for two distinct nonlymphoid-specific genes that encode factors involved in both DNA repair and V(D)J recombination.
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Cites
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The V(D)J recombination activating gene, RAG-1
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The SCID Mouse Mutant: Definition, Characterization, and Potential Uses
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The scid mutation in mice causes a general defect in DNA repair
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Cited by
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637
Self-citationXRCC3 promotes homology-directed repair of DNA damage in mammalian cells
Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,379
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
Moshous, D., Callebaut, I., de Chasseval, R., Corneo, B., Cavazzana-Calvo, M., Le Deist, F., Tezcan, I., Sanal, O., Bertrand, Y., Philippe, N., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00309-9 · Cited by 912
Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice
Gu, Y., Seidl, K. J., Rathbun, G. A., Zhu, C., Manis, J. P., van der Stoep, N., Davidson, L., Cheng, H.-L., Sekiguchi, J. M., Frank, K., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80386-6 · Cited by 451
Self-citation
Metadata
- Authors
- Taccioli, G. E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P. A., & Alt, F. W.
- Venue
- Science
- Published
- 1993-04-09
- Volume
- 260
- Issue
- 5105
- Pages
- 207-210
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038794308
- Cited by
- 451
- References
- 26
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taccioli, G. E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P. A., & Alt, F. W. (1993). Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants. Science. https://doi.org/10.1126/science.8469973
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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