The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a)
Abstract
Elevated blood concentrations of lipoprotein(a) [Lp(a)] and its constituent, apolipoprotein(a) [apo(a)], constitute a major risk factor for atherosclerosis, but their physiological activities remain obscure. Lp(a) and purified apo(a) stimulated the growth of human smooth muscle cells in culture. This effect resulted from inhibition of plasminogen activation, and consequently the activation by plasmin of latent transforming growth factor-β, which is an inhibitor of smooth muscle cell growth. Because smooth muscle proliferation is one of the hallmarks of atherosclerotic lesions, these results point to a plausible mechanism for the atherogenic activity of Lp(a).
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Citations
Cites
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886
Self-citationThe mysteries of lipoprotein(a).
Utermann, G. (1989) · Science · doi:10.1126/science.2530631 · Cited by 1,257
Transforming Growth Factor-β: Biological Function and Chemical Structure
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Lp(a) Lipoprotein as a Risk Factor for Myocardial Infarction
Rhoads, G. G. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380180102027 · Cited by 783
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Cited by
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413
(2007) · Endocrine Practice · doi:10.4158/ep.13.s1.1 · Cited by 699
Lipoprotein(a): resurrected by genetics
Kronenberg, F., & Utermann, G. (2013) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02592.x · Cited by 521
Arsenault, B. J., Boekholdt, S. M., Dubé, M.-P., Rhéaume, É., Wareham, N. J., Khaw, K.-T., Sandhu, M. S., & Tardif, J.-C. (2014) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.113.000400 · Cited by 315
Kronenberg, F., Kronenberg, M. F., Kiechl, S., Trenkwalder, E., Santer, P., Oberhollenzer, F., Egger, G., Utermann, G., & Willeit, J. (1999) · Circulation · doi:10.1161/01.cir.100.11.1154 · Cited by 293
Metadata
- Authors
- Grainger, D. J., Kirschenlohr, H. L., Metcalfe, J. C., Weissberg, P. L., Wade, D. P., & Lawn, R. M.
- Venue
- Science
- Published
- 1993-06-11
- Volume
- 260
- Issue
- 5114
- Pages
- 1655-1658
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983055162
- Cited by
- 408
- References
- 28
- FWCI
- 47.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grainger, D. J., Kirschenlohr, H. L., Metcalfe, J. C., Weissberg, P. L., Wade, D. P., & Lawn, R. M. (1993). Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a). Science. https://doi.org/10.1126/science.8503012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
