The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Switch of CD8 T Cells to Noncytolytic CD8 - CD4 - Cells that Make T H 2 Cytokines and Help B Cells
Abstract
CD8 + T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-γ (IFN-γ) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8 + T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8 - CD4 - population that was not cytolytic and did not produce IFN-γ. However, these CD8 - cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.
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Citations
Cites
IL‐4 directs the development of Th2‐like helper effectors
Swain, S. L., Weinberg, A. D., English, M., & Huston, G. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.11.3796 · Cited by 1,254
Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954
Cited by
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Trinchieri, G. (1998) · Advances in Immunology · doi:10.1016/s0065-2776(08)60387-9 · Cited by 760
Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases
Lucey, D. R., Clerici, M., & Shearer, G. M. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.532 · Cited by 666
Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M. K., & Adorini, L. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.2.817 · Cited by 423
Cytokines and immunity to viral infections
Ramshaw, I. A., Ramsay, A. J., Karupiah, G., Rolph, M. S., Mahalingam, S., & Ruby, J. C. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01011.x · Cited by 257
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.
Coyle, A. J., Erard, F., Bertrand, C., Walti, S., Pircher, H., & Le Gros, G. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.1229 · Cited by 254
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Metadata
- Authors
- Erard, F., Wild, M.-T., Garcia-Sanz, J. A., & Le Gros, G.
- Venue
- Science
- Published
- 1993-06-18
- Volume
- 260
- Issue
- 5115
- Pages
- 1802-1805
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090896399
- Cited by
- 331
- References
- 2
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Erard, F., Wild, M.-T., Garcia-Sanz, J. A., & Le Gros, G. (1993). Switch of CD8 T Cells to Noncytolytic CD8 - CD4 - Cells that Make T H 2 Cytokines and Help B Cells. Science. https://doi.org/10.1126/science.8511588
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