The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.
Open accessAbstract
Virus infections of the lung are thought to predispose individuals to asthma, a disease characterized by eosinophil infiltration of the airways. CD8+ T cells are an important part of the host response to virus infection, however, they have no reported role in eosinophil recruitment. We developed a mouse model of virus peptide-stimulated CD8+ T cell immune responses in the lung. We found that bystander CD4+ T helper cell type 2 immune responses to ovalbumin switched the virus peptide-specific CD8+ T cells in the lung to interleukin (IL) 5 production. Furthermore, when such IL-5-producing CD8 T cells were challenged via the airways with virus peptide, a significant eosinophil infiltration was induced. In vitro studies indicated that IL-4 could switch the virus-specific CD8+ T cells to IL-5 production. These results could explain the link between virus infection and acute exacerbation of asthma and, perhaps more importantly, they indicate an IL-4-dependent mechanism that would impair CD8+ T cell responses and delay viral clearance from the host.
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Cites
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Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice
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Cited by
Mechanisms of eosinophil-associated inflammation
Gleich, G. J. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.105712 · Cited by 785
Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases
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Cytokines and immunity to viral infections
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Metadata
- Authors
- Coyle, A. J., Erard, F., Bertrand, C., Walti, S., Pircher, H., & Le Gros, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-03-01
- Volume
- 181
- Issue
- 3
- Pages
- 1229-1233
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1993599565
- Cited by
- 254
- References
- 15
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia. https://app.cochat.ai/papers/10.1084/jem.181.3.1229
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- Coyle, A. J., Erard, F., Bertrand, C., Walti, S., Pircher, H., & Le Gros, G. (1995). Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.181.3.1229
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
