The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Rod Outer Segment Disk Shedding in Rat Retina: Relationship to Cyclic Lighting
Abstract
When albino rats are reared in cyclic light, a burst of rod outer segment disk shedding occurs in the retina soon after the onset of light. The number of large packets of outer segment disks (phagosomes) in the pigment epithelium at this time is 2.5 to 5 times greater than at any other time of day or night. The subsequent degradation of large phagosomes to smaller structures within pigment epithelial cells proceeds rapidly. The burst of disk shedding follows a circadian rhythm for at least 3 days, since it occurs in continuous darkness at the same time without the onset of light.
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In the citing paper
“LaVail (1976) first reported a greater number of phagosomes in the rat RPE after light onset.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“However, in his original paper, LaVail showed that blockage of the rat pineal gland with reserpine prevented the sudden increase in phagosome number that occurs after light onset (LaVail, 1976), suggesting some extraocular influence on circadian OS phagocytosis.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“Most animals (including mouse, rat, cat, hamster, Xenopus laevis, goldfish, rabbit, and chick) appear to be entrained to a circadian rhythm, which is cued by the light/dark cycle and persists even when the animal is maintained in absolute darkness (LaVail, 1976; Besharse et al., 1977; Grace et al., 1996), but not in absolute light (Teirstein et al., 1980).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“due to their fresh dissection, reflect the in vivo circadian rhythm of OS phagocytosis (LaVail, 1976)”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“POS disk phagocytosis is triggered according to a daily cycle at the beginning of the light phase (LaVail, 1976)”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as LaVail, 1976
In the citing paper
“The ingested POS phagosomes then migrate from the apical region into the cell and are degraded (Gibbs et al., 2003), mimicking events that occur in vivo (LaVail, 1976; Herman and Steinberg, 1982).”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as LaVail, 1976
Citations
Cites
The renewal of photoreceptor cell outer segments
Young, R. W. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.33.1.61 · Cited by 1,184
The Pineal Gland: A Neurochemical Transducer
Axelrod, J. (1974) · Science · doi:10.1126/science.184.4144.1341 · Cited by 875
Visual cells and the concept of renewal.
Young, R. W. (1976) · PubMed · Cited by 483
THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
Young, R. W., & Droz, B. (1968) · Journal of Cell Biology · doi:10.1083/jcb.39.1.169 · Cited by 401
THE RENEWAL OF ROD AND CONE OUTER SEGMENTS IN THE RHESUS MONKEY
Young, R. W. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.2.303 · Cited by 375
Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat
LaVail, M. M., & Battelle, B. (1975) · Experimental Eye Research · doi:10.1016/0014-4835(75)90080-9 · Cited by 331
Self-citationPARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS
Young, R. W., & Bok, D. (1969) · Journal of Cell Biology · doi:10.1083/jcb.42.2.392 · Cited by 271
Photoreceptor shedding is initiated by light in the frog retina
Basinger, S., Hoffman, R., & Matthes, M. (1976) · Science · doi:10.1126/science.1086510 · Cited by 227
Hall, M. O., Bok, D., & Bacharach, A. D. E. (1969) · Journal of Molecular Biology · doi:10.1016/0022-2836(69)90114-4 · Cited by 223
Shedding of discs from rod outer segments in the rhesus monkey
Young, R. W. (1971) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(71)90014-1 · Cited by 206
KINETICS OF ROD OUTER SEGMENT RENEWAL IN THE DEVELOPING MOUSE RETINA
LaVail, M. M. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.58.3.650 · Cited by 189
Self-citationDeguchi, T., & Axelrod, J. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2411 · Cited by 161
THE FINE STRUCTURE OF THE PIGMENT EPITHELIUM IN THE ALBINO RAT
Dowling, J. E., & Gibbons, I. R. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.14.3.459 · Cited by 159
Outer Segments of Photoreceptors and the Retinal Pigment Epithelium
Spitznas, M. (1970) · Archives of Ophthalmology · doi:10.1001/archopht.1970.00990040812022 · Cited by 137
Rod outer segment disc shedding in relation to cyclic lighting
LaVail, M. M. (1976) · Experimental Eye Research · doi:10.1016/0014-4835(76)90209-8 · Cited by 120
Self-citationThe effect of light on the quantity of phagosomes in the pigment epithelium
Hollyfield, J. G., Besharse, J. C., & Rayborn, M. E. (1976) · Experimental Eye Research · doi:10.1016/0014-4835(76)90221-9 · Cited by 68
Circadian Rhythm in Pineal Serotonin: Effect of Monoamine Oxidase Inhibition and Reserpine
Snyder, S. H., & Axelrod, J. (1965) · Science · doi:10.1126/science.149.3683.542 · Cited by 64
Essential fatty acid deficiency and renewal of rod outer segments in the albino rat.
Anderson, R. E., Landis, D. J., & Dudley, P. A. (1976) · PubMed · Cited by 35
Retinal adhesion in light- and dark-adapted rabbits.
Owczarek, F. R., Marak, G. E., & Pilkerton, A. R. (1975) · PubMed · Cited by 22
Phagocytosis in the normal and ischaemic retinal pigment epithelium of the rabbit.
Johnson, N. F. (1975) · Experimental Eye Research · doi:10.1016/0014-4835(75)90147-5 · Cited by 16
Flagged first, then by citations
Research works printed but not linked: 2
- Ishikawa, T., Journal of Electron Microscopy (Tokyo) 19: 85 (1970).
- KLEIN, D.C., NEUROSCIENCES 3 STUD: 509 (1974).
Cited by
Sorted by citations
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker
Czeisler, C. A., Kronauer, R. E., Allan, J. S., Duffy, J. F., Jewett, M. E., Brown, E. N., & Ronda, J. M. (1989) · Science · doi:10.1126/science.2734611 · Cited by 946
Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy
Carter‐Dawson, L. D., & LaVail, M. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901880204 · Cited by 695
Self-citationThe retinal pigment epithelium: a versatile partner in vision
Bok, D. (1993) · Journal of Cell Science · doi:10.1242/jcs.1993.supplement_17.27 · Cited by 593
Retinal light damage: Mechanisms and protection
Organisciak, D. T., & Merriman, D. K. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.11.004 · Cited by 558
Metadata
- Authors
- LaVail, M. M.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- LaVail, Matthew M.
- Venue
- Science
- Published
- 1976-12-03
- Volume
- 194
- Issue
- 4269
- Pages
- 1071-1074
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051747007
- Cited by
- 689
- References
- 20
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 14 · 2020: 24 · 2019: 18 · 2018: 24 · 2017: 16 · 2016: 9 · 2015: 25 · 2014: 21 · 2013: 11 · 2012: 15
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- phagosome, retinal pigment epithelium, circadian rhythm, albino rats, photoreceptors
- MeSH terms
- Animals, Circadian Rhythm, Light, Organoids, Phagocytosis, Photoreceptor Cells, Pigment Epithelium of Eye, Reserpine, Rats
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