Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Rizvi, Naiyer A., Hellmann, Matthew D., Snyder, Alexandra, Kvistborg, Pia, Makarov, Vladimir, Havel, Jonathan J., Lee, William, Yuan, Jianda +16 more·2015·Science

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  3. High-dose vitamin C enhances cancer immunotherapy
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  5. Resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms, predictive factors, and future perspectives
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  8. Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade
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  9. Current Diagnosis and Management of Small-Cell Lung Cancer
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  10. Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer
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  11. Antitumour immunity regulated by aberrant ERBB family signalling
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  12. Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion
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  13. Pembrolizumab for the treatment of non-small cell lung cancer
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  14. Precision Oncology: Who, How, What, When, and When Not?
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  15. The Superior Efficacy of Anti-PD-1/PD-L1 Immunotherapy in KRAS-Mutant Non-Small Cell Lung Cancer that Correlates with an Inflammatory Phenotype and Increased Immunogenicity
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  16. Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system
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    Yu, Helena A., Suzawa, Ken, Jordan, Emmet, Zehir, Ahmet, Ni, Ai, Kim, Ryan, Kris, Mark G., Hellmann, Matthew D., Li, Bob T., Somwar, Romel et al. · 2018 · Clinical Cancer Research
  25. Diagnosis and Molecular Classification of Lung Cancer
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  26. Emerging role of tumor cell plasticity in modifying therapeutic response
    Siyuan Qin, Jingwen Jiang, Yi Lü, Edouard Collins Nice, Canhua Huang, Jian Zhang, Weifeng He · 2020 · Signal Transduction and Targeted Therapy
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    Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia et al. · 2021 · Cancer Discovery
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  44. KRAS Secondary Mutations That Confer Acquired Resistance to KRAS G12C Inhibitors, Sotorasib and Adagrasib, and Overcoming Strategies: Insights From In Vitro Experiments
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  46. Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis
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  47. Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer
    Jae-Won Cho, Min Hee Hong, Sang‐Jun Ha, Young‐Joon Kim, Byoung Chul Cho, Insuk Lee, Hye Ryun Kim · 2020 · Experimental & Molecular Medicine
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  50. A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer
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  52. Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
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  55. Challenges in developing personalized neoantigen cancer vaccines
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  56. Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
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  57. Novel immunotherapies in lymphoid malignancies
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  58. An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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  65. Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade
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  66. Biomarkers for immunotherapy response in head and neck cancer
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  72. Lung Cancer Biomarkers
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