High-dose vitamin C enhances cancer immunotherapy
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Vitamin C promotes anticancer adaptive immunity and enhances efficacy of immune checkpoint therapy.
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A potential mechanism underlying the association between diet and immunotherapy response is the gut microbiome.
“A potential mechanism underlying the association between diet and immunotherapy response is the gut microbiome.”
From Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma (2023) · cites this paper as [14]
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- Authors
- Magrì, A., Germano, G., Lorenzato, A., Lamba, S., Chilà, R., Montone, M., Amodio, V., Ceruti, T., Sassi, F., Arena, S., Abrignani, S., D’Incalci, M., Zucchetti, M., Di Nicolantonio, F., & Bardelli, A.
- Affiliations
- Candiolo Cancer Institute (IT)
- IFOM (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Milan (IT)
- Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.
- Corresponding author
- Magrì, Alessandro
- Germano, Giovanni
- Bardelli, Alberto
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-02-26
- Volume
- 12
- Issue
- 532
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3008623708
- Cited by
- 285
- References
- 55
- Citations by year
- 2026: 33 · 2025: 44 · 2024: 59 · 2023: 39 · 2022: 48 · 2021: 41 · 2020: 21
- FWCI
- 23.55
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Cancer Research UK (22795)
- Ministero della Salute (NET-2011-02352137, 21091)
- Associazione Italiana per la Ricerca sul Cancro (IG-2018, #21407, AIRC IG 2018, 21091, 21923, 22795, ID.21091)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- vitamin C, high-dose ascorbic acid, cancer immunotherapy, immune checkpoint inhibitors, CD8+ T cells, tumor microenvironment, tumor mutational burden, breast cancer, colorectal cancer, melanoma, pancreatic cancer, combination therapy
- MeSH terms
- Animals, Antineoplastic Agents, Ascorbic Acid, Immunotherapy, Melanoma, Mice, Tumor Microenvironment
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