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Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo

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Energetic adaptations: Metabolic control of endocytic membrane traffic

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Staying in touch with the endocytic network: The importance of contacts for cholesterol transport

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Spatial regulation of mTORC1 signalling: Beyond the Rag GTPases

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The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

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Organelle Cooperation in Stem Cell Fate: Lysosomes as Emerging Regulators of Cell Identity

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Rheb regulates nuclear mTORC1 activity independent of farnesylation

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New Insights into the Regulation of mTOR Signaling via Ca2+-Binding Proteins

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mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells

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Amino Acids in Autophagy: Regulation and Function

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A proteomic view on lysosomes

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The Fast and the Furious: Golgi Contact Sites

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Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin

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Lysosomes: guardians and healers within cells- multifaceted perspective and outlook from injury repair to disease treatment

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NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells

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Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK

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Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth

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VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes

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Autophagosome Formation: Cutting the Gordian Knot at the ER

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Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation

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TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response

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SEA and GATOR 10 Years Later

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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila

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mTOR Senses Intracellular pH through Lysosome Dispersion from RHEB

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Copper‐independent lysosomal localisation of the Wilson disease protein ATP7B

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Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases

Moors, T. E., Morella, M. L., Bertran-Cobo, C., Geut, H., Udayar, V., Huisman, E., Ingrassia, A. M. T., Brevé, J. J. P., Bol, J. G. J. M., Bonifati, V., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02707-z · Cited by 11 · see citing works

Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan

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Lysosomes and Their Role in Regulating the Metabolism of Hematopoietic Stem Cells

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The skeletal muscle fiber periphery: A nexus of mTOR-related anabolism

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Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis

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GOLPH3-mTOR Crosstalk and Glycosylation: A Molecular Driver of Cancer Progression

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Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation

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H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication

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Directly imaging the localisation and photosensitization properties of the pan-mTOR inhibitor, AZD2014, in living cancer cells

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The complex web of membrane contact sites in brain aging and neurodegeneration

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EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint.

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The role of membrane contact sites at the bacteria-host interface

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Arf5-mediated regulation of mTORC1 at the plasma membrane

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The role of leucine in the activation of cellular metabolism: a large integrative review

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Get Closer to the World of Contact Sites: A Beginner's Guide to Proximity-Driven Fluorescent Probes

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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

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The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B

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Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

Armijo, M. E., Escalona, E., Peña, D., Farías, A., Morı́n, V., Baumann, M., Klebl, B., Pincheira, R., & Castro, A. F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.912688 · Cited by 2 · see citing works

The Lysosome Signaling Platform: Adapting With the Times

Inpanathan, S., & Botelho, R. (2023) · doi:10.32920/21982901 · Cited by 2 · see citing works

Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid AvailabilityPreprint

Fernandes, S. A., Angelidaki, D.-D., Nüchel, J., Pan, J., Gollwitzer, P., Elkis, Y., Artoni, F., Wilhelm, S., Kovacevic-Sarmiento, M., & Demetriades, C. (2023) · bioRxiv · doi:10.1101/2023.10.03.559930 · Cited by 1 · see citing works

Control of GSK3β nuclear localization by amino acid signaling requires GATOR1 but is mTORC1-independentPreprint

Forkel, D. S., Ibazebo, O., Soha, S. A., Bautista, S. J., Impellizzeri, S., Botelho, R. J., Hesketh, G., Gingras, A., & Antonescu, C. (2024) · bioRxiv · doi:10.1101/2024.04.09.588669 · Cited by 2 · see citing works

The role of lysosomes in autophagy

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Impact of Golgi dynamics and Golgi morphology on the regulation of glycosylation

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YIF1A activates mTORC1 signaling to promote cellular senescence

Zhang, X., Liu, L., Shang, M., Hu, B., Zhu, S., Wang, X., Jieying, L., Han, Y., Wei, X., Cao, Q., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09034-z · Cited by 1 · see citing works

A cellular protection racket: How lysosomal Ca2+ fluxes prevent kidney injury

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Cross-linking of the Endolysosomal System Reveals Flotillin Structures and Putative CargoPreprint

Singh, J., Elhabashy, H., Muthukottiappan, P., Stepath, M., Eisenacher, M., Kohlbacher, O., Gieselmann, V., & Winter, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.12.475930

Faculty Opinions recommendation of mTOR at the nexus of nutrition, growth, ageing and disease.

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Copper-independent lysosomal localization of the Wilson disease protein ATP7BPreprint

Maji, S., Pirozzi, M., Ruturaj, Pandey, R., Ghosh, T., Das, S., & Gupta, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.30.514457

The Lysosome Signaling Platform: Adapting With the Times

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Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and GBA -related Parkinson’s disease and Dementia with Lewy bodiesPreprint

Moors, T. E., Morella, M. L., Bertran-Cobo, C., Geut, H., Udayar, V., Huisman, E., Ingrassia, A. M. T., Brevé, J. J. P., Bol, J. G. J. M., Bonifati, V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.16.549189

Control of GSK3β nuclear localization by amino acid signaling requires GATOR1 but is mTORC1-independentPreprint

Forkel, D. S., Ibazebo, O., Soha, S. A., Bautista, S. J., Impellizzeri, S., Botelho, R. J., Hesketh, G. G., Gingras, A., & Antonescu, C. N. (2024) · doi:10.32920/26015170

Control of GSK3β nuclear localization by amino acid signaling requires GATOR1 but is mTORC1-independentPreprint

Forkel, D. S., Ibazebo, O., Soha, S. A., Bautista, S. J., Impellizzeri, S., Botelho, R., Hesketh, G. G., Gingras, A., & Antonescu, C. N. (2024) · doi:10.32920/26015170.v1

Rheb membrane orientation dynamics and functional consequences elucidated by molecular simulations, single-molecule-FRET and signaling assaysPreprint

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Role of p27/Kip1 in auphagy under metabolic stress conditions

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Biochemical characterization of mTORC1 regulation by glutamine metabolism

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The role of GATOR1 complex, upstream regulator of mTORC1 pathway, in mitochondrial function

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The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and Plasticity

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Rheb and Rags come together at the lysosome to activate mTORC1

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Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment

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Lysosomal catch-and-release controls mTORC1

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