Cited by 347Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescencePluripotent Stem Cells Research

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Stem cells and healthy aging

Goodell, Margaret A., Rando, Thomas A.·2015·Science

DOI 10.1126/science.aab3388

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Abstract

Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of aging on stem cells in different tissues. Recent research has focused on the ways that genetic mutations, epigenetic changes, and the extrinsic environmental milieu influence stem cell functionality over time. We describe each of these three factors, the ways in which they interact, and how these interactions decrease stem cell health over time. We are optimistic that a better understanding of these changes will uncover potential strategies to enhance stem cell function and increase tissue resiliency into old age.

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Authors: Goodell, M. A., & Rando, T. A.
Affiliations: Baylor College of Medicine (US)
VA Palo Alto Health Care System (US)
Corresponding author: Goodell, Margaret A.
Rando, Thomas A.
ORCID: Goodell, Margaret A.
Rando, Thomas A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-12-04
Volume: 350
Issue: 6265
Pages: 1199-1204
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aab3388
OpenAlex: W2194928240
Cited by: 347
References: 52
Citations by year: 2026: 19 · 2025: 33 · 2024: 31 · 2023: 43 · 2022: 36 · 2021: 33 · 2020: 28 · 2019: 43 · 2018: 32 · 2017: 35 · 2016: 12 · 2015: 2
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs (I01RX001222)
National Institute on Aging (R37AG023806, R01AG047820, P01AG036695)
National Cancer Institute (R01CA183252)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092883)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR062185)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: stem cells, healthy aging, stem cell aging, adult stem cells, tissue regeneration, genetic mutations, epigenetic modifications, tissue resilience, regenerative capacity
MeSH terms: Aging, Animals, Health, Humans, Mutation, Organ Specificity, Selection, Genetic, Cellular Senescence, Genetic Drift, Epigenesis, Genetic, Mice, Adult Stem Cells

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