The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Stem cells and healthy aging
Abstract
Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy aging. Here, we explore the effects of aging on stem cells in different tissues. Recent research has focused on the ways that genetic mutations, epigenetic changes, and the extrinsic environmental milieu influence stem cell functionality over time. We describe each of these three factors, the ways in which they interact, and how these interactions decrease stem cell health over time. We are optimistic that a better understanding of these changes will uncover potential strategies to enhance stem cell function and increase tissue resiliency into old age.
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“Studies in other tissues have demonstrated that at least delaying components of the aging process can be a viable strategy, 106”
From Aging of hematopoietic stem cells (2018) · cites this paper as [106]
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“Ageing leads to a decline in tissue stem cell function3–5.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [3]
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Metadata
- Authors
- Goodell, M. A., & Rando, T. A.
- Affiliations
- Baylor College of Medicine (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Goodell, Margaret A.
- Rando, Thomas A.
- Venue
- Science
- Published
- 2015-12-04
- Volume
- 350
- Issue
- 6265
- Pages
- 1199-1204
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2194928240
- Cited by
- 347
- References
- 52
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 31 · 2023: 43 · 2022: 36 · 2021: 33 · 2020: 28 · 2019: 43 · 2018: 32 · 2017: 35 · 2016: 12 · 2015: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01RX001222)
- National Institute on Aging (R37AG023806, R01AG047820, P01AG036695)
- National Cancer Institute (R01CA183252)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092883)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR062185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- stem cells, healthy aging, stem cell aging, adult stem cells, tissue regeneration, genetic mutations, epigenetic modifications, tissue resilience, regenerative capacity
- MeSH terms
- Aging, Animals, Health, Humans, Mutation, Organ Specificity, Selection, Genetic, Cellular Senescence, Genetic Drift, Epigenesis, Genetic, Mice, Adult Stem Cells
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