The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Open accessAbstract
The clockwork of insulin release: In healthy people, blood glucose levels are maintained within a narrow range by several physiological mechanisms. Key among them is the release of the hormone insulin by pancreatic β cells, which occurs when glucose levels rise after a meal. In response to insulin, blood glucose is taken up by tissues that need fuel, such as muscle. β cells can anticipate the body's varying demand for insulin throughout the 24-hour day because they have their own circadian clock. How this clock controls insulin release has been unclear. Perelis et al. now show that the activity of transcriptional enhancers specific to β cells regulates the rhythmic expression of genes involved in the assembly and trafficking of insulin secretory vesicles (see the Perspective by Dibner and Schibler). Science , this issue p. 10.1126/science.aac4250 ; see also p. 628
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Cited by
Transcriptional architecture of the mammalian circadian clock
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Circadian physiology of metabolism
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Circadian time signatures of fitness and disease
Bass, J., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 607
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Metadata
- Authors
- Perelis, M., Marcheva, B., Moynihan Ramsey, K., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., Allred, A. L., Bradfield, C. A., Dinner, A. R., Barish, G. D., & Bass, J.
- Venue
- Science
- Published
- 2015-11-06
- Volume
- 350
- Issue
- 6261
- Pages
- aac4250-aac4250
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2140464228
- Cited by
- 377
- References
- 55
- FWCI
- 33.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Perelis, M., Marcheva, B., Moynihan Ramsey, K., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., Allred, A. L., Bradfield, C. A., Dinner, A. R., Barish, G. D., & Bass, J. (2015). Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science. https://doi.org/10.1126/science.aac4250
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