mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J. H., Asara, John M., Manning, Brendan D.·2016·Science
Cited by (807)
Items 401–500 of 807
- RETRACTED: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletionMahsa Zarei, Heng Du, Amin H. Nassar, Rachel Yan, Krinio Giannikou, Sneha H. Johnson, Hilaire Colletta Lam, Elizabeth P. Henske, Yubao Wang, Tinghu Zhang et al. · 2019 · The Journal of Experimental Medicine · Retracted
- Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer CellsAmanda L. Peterson, Adam K. Walker, Erica K. Sloan, Darren J. Creek · 2016 · Metabolites
- mTOR Signaling in Aquaculture Animals: A Central Nutrient‐Sensing Hub Orchestrating Growth, Metabolism, Health and QualityYue Liu, Kangsen Mai, Wenbing Zhang · 2025 · Reviews in Aquaculture
- One-Carbon Metabolism Associated Vulnerabilities in Glioblastoma: A ReviewKimia Ghannad‐Zadeh, Sunit Das · 2021 · Cancers
- Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease ProgressionNora Pällmann, Ke Deng, Marte Livgård, Martina Tesikova, Yixin Jin, Nicolai Sebastian Frengen, Nermin Kahraman, Hamada Ahmed Mokhlis, Bülent Özpolat, Wanja Kildal et al. · 2021 · Cancer Research
- Exosomal miR-673-5p from fibroblasts promotes Schwann cell-mediated peripheral neuron myelination by targeting the TSC2/mTORC1/SREBP2 axisYahong Zhao, Yunyun Liang, Zhixin Xu, Jina Liu, Xiaoyu Liu, Jinyu Ma, Cheng Sun, Yumin Yang · 2022 · Journal of Biological Chemistry
- Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain DevelopmentTomoya Mizukoshi, Seiya Yamada, Shin‐ichi Sakakibara · 2023 · eNeuro
- Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR SignalingMarcelo G. Pereira, Kenneth Allen Dyar, Leonardo Nogara, Francesca Solagna, Manuela Marabita, Martina Baraldo, Francesco Chemello, Elena Germinario, Vanina Romanello, Hendrik Nolte et al. · 2017 · Frontiers in Physiology
- Transcriptional Regulation of NK Cell Development by mTOR ComplexesChao Yang, Subramaniam Malarkannan · 2020 · Frontiers in Cell and Developmental Biology
- Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapauseVera Anna van der Weijden, Jochen Bick, Stefan Bauersachs, Anna B. Rüegg, Thomas B. Hildebrandt, Frank Göritz, Katarina Jewgenow, Pieter Giesbertz, Hannelore Daniel, Emilie Derisoud et al. · 2021 · Proceedings of the National Academy of Sciences
- mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-β and in pulmonary fibrosisKun Woo D Shin, Volkan Atalay, Rengül Çetin-Atalay, Erin M O’Leary, Mariel Glass, Jennifer C. Houpy Szafran, Parker S. Woods, Angelo Y. Meliton, Obada R. Shamaa, Yufeng Tian et al. · 2025 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stressLê Thị Thu Hiền, Jiyoung Yu, Hee‐Sung Ahn, Mi‐Jeong Kim, In Gyeong Chae, Hyun-Nam Cho, Juhee Kim, Hye‐Kyung Park, Hyuk Nam Kwon, Han–Jung Chae et al. · 2025 · Molecules and Cells
- Integrated Functions of Cardiac Energetics, Mechanics, and Purine Nucleotide MetabolismRachel Lopez‐Schenk, Nicole L. Collins, Noah A. Schenk, Daniel Andrew Beard · 2024 · Comprehensive physiology
- The role of mTOR signaling pathway in systemic lupus erythematosus and systemic vasculitisDespina Michailidou, Yevgeniya Gartshteyn, Anca Askanase, András Perl · 2025 · Autoimmunity Reviews
- Integration of proteomics and metabolomics reveals promotion of proliferation by exposure of bisphenol S in human breast epithelial MCF-10A cellsWei Huang, Lin Zhu, Chao Zhao, Xiangfeng Chen, Zongwei Cai · 2020 · The Science of The Total Environment
- Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axisDat P. Ha, Amy Shiu Lee · 2020 · Cellular Signalling
- Novel Ferrocene Derivatives Induce Apoptosis through Mitochondria-Dependent and Cell Cycle Arrest via PI3K/Akt/mTOR Signaling Pathway in T Cell Acute Lymphoblastic LeukemiaLiao Zeng, Mingqing Tang, Chao Pi, Jianrong Zheng, Sanxing Gao, Titaua Chabanne, Rémi Chauvin, Wenzhao Cheng, Hongjun Lin, Ruian Xu et al. · 2021 · Cancers
- V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegansTerytty Yang Li, Arwen W. Gao, Xiaoxu Li, Hao Li, Yasmine J. Liu, Amélia Lalou, Nagammal Neelagandan, Félix Naef, Kristina Schoonjans, Johan H. Auwerx · 2022 · The Journal of Cell Biology
- Phosphoribosyltransferases and Their Roles in Plant Development and Abiotic Stress ResponseYe Liu, Peiwen Wu, Bowen Li, Weihao Wang, Benzhong Zhu · 2023 · International Journal of Molecular Sciences
- Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway RegulationChunliang Liu, Giselle M. Knudsen, Anthony M. Pedley, Jingxuan He, Jared Lee Johnson, Tomer M. Yaron, Lewis C. Cantley, Stephen J. Benkovic · 2019 · Journal of Proteome Research
- Translational regulation in stress biologyNaomi R. Genuth, Andrew G. Dillin · 2025 · Nature Cell Biology
- The Role of MicroRNAs in Lung Cancer MetabolismMohamed Iman Hidayat Nor Azizi, Iekhsan Othman, Rakesh Naidu · 2021 · Cancers
- Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discoveryRaef S. Shams, Yoshihiro Ito, Hideyuki Miyatake · 2021 · Pharmacology & Therapeutics
- MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister stateWen Cai Zhang, Nicholas G. Skiados, Fareesa Aftab, Cerena Moreno, Luis Silva, Paul Joshua Anthony Corbilla, John M. Asara, Aaron N. Hata, Frank John Slack · 2022 · Cancer Gene Therapy
- Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeriaJanne Purhonen, Rishi Banerjee, Vilma Wanne, Nina Sipari, Matthias Mörgelin, Vineta Fellman, Jukka Kallijärvi · 2023 · Nature Communications
- Unveiling the Role of Mechanistic Target of Rapamycin Kinase (MTOR) Signaling in Cancer Progression and the Emergence of MTOR Inhibitors as Therapeutic StrategiesDevashish Mehta, Kajal Rajput, Dolly Jain, Avinash Bajaj, Ujjaini Dasgupta · 2024 · ACS Pharmacology & Translational Science
- Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogenŞafak Bayram, Susanne Fürst, Martin Forbes, Stefan Kempa · 2019 · Molecular Metabolism
- Acidity induces durable enhancement of Treg cell suppressive functions for tumor immune evasionNikita Lavanya Mani, Samuel Edward Weinberg, Shuvam Mohan Chaudhuri, Elena I Montauti, Amy Y. Tang, Radhika Iyer, Deyu Fang · 2024 · Molecular Immunology
- Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapyChangxian Shen, Yuqi He, Qiang Chen, Haihua Feng, Terence Marques Williams, Yuanzhi Lu, Zhengfu He · 2021 · Annals of Translational Medicine
- L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axisSho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino‐Sakamoto, Naoya Sakamoto, Ken‐ichi Yasumoto et al. · 2023 · Oncogene
- Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive FunctionTakashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama et al. · 2017 · The Journal of Immunology
- A Multi-Omics Analysis of Mucosal-Associated-Invariant T Cells Reveals Key Drivers of Distinct Modes of ActivationKristin A. Schubert, Isabel Karkossa, Jana Schor, Beatrice Engelmann, Lisa Maria Steinheuer, Tony Bruns, Ulrike Elisabeth Rolle-Kampczyk, Jörg Hackermüller A, Martin von Bergen� · 2021 · Frontiers in Immunology
- Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signalingXiangrong Cui, Huancheng Su, Jiaolin Yang, Xueqing Wu, Kai Huo, Xuan Jing, Sanyuan Zhang · 2022 · Journal of Ovarian Research
- mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing LossMaurizio Cortada, Soledad Levano, Daniel Bodmer · 2021 · International Journal of Molecular Sciences
- Targeting mTOR in the Context of Diet and Whole-body MetabolismNikos Koundouros, John Blenis · 2022 · Endocrinology
- Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar et al. · 2023 · Metabolism
- Targeting purine metabolism-related enzymes for therapeutic intervention: A review from molecular mechanism to therapeutic breakthroughDi Wu, Shengqiang Yang, Chenyang Yuan, Kejia Zhang, Jiachen Tan, Kaifeng Guan, Hong Zeng, Chunjie Huang · 2024 · International Journal of Biological Macromolecules
- MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61Mahsa Zarei, Krinio Giannikou, Heng Du, Heng-Jia Liu, Melissa Duarte, Sneha H. Johnson, Amin H. Nassar, Hans R. Widlund, Elizabeth P. Henske, Henry W. Long et al. · 2020 · Oncogene
- The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemiaGuihao Chen, Vincent Phan, Xiang Luo, Dian J. Cao · 2021 · Journal of Molecular and Cellular Cardiology
- De Novo Purine Nucleotide Biosynthesis Pathway Is Required for Development and Pathogenicity in Magnaporthe oryzaeMengyu Liu, Li‐Xiao Sun, Hui Qian, Yun‐Ran Zhang, Xue‐Ming Zhu, Lin Li, Shuang Liang, Jianping Lu, Fu‐Cheng Lin, Xiaohong Liu · 2022 · Journal of Fungi
- MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitorsHaEun Kim, Benjamin Lebeau, David J. Papadopoli, Predrag Jovanović, Mariana De Sa Tavares Russo, Daina Zofija Avizonis, Masahiro Morita, Farzaneh Afzali, Josie Ursini‐Siegel, Lynne-Marie M Postovit et al. · 2024 · iScience
- The central role of mitochondrial metabolism in hepatic steatosisSanda Win, Tin Aung Than, Neil Kaplowitz, Nicole Wong, Aliza Arya, Zin Thandar Win, Shwe Hlaing Win, Ei Phyu, Christina Kuemerle, Jake Suh et al. · 2024 · Exploration of Digestive Diseases
- Polyploidy and mTOR signaling: a possible molecular linkDebopriya Choudhury, Dhruba Ghosh, Meghna Mondal, Didhiti Singha, Ramesh Pothuraju, Pushkar Malakar · 2024 · Cell Communication and Signaling
- Folate pathways mediating the effects of ethanol in tumorigenesisJaspreet Sharma, Sergey A. Krupenko · 2020 · Chemico-Biological Interactions
- Sestrin2 and mitochondrial quality control: potential impact in myogenic differentiation.L. F. Piochi, Ivo F. Machado, C. Palmeira, A. Rolo · 2021 · Ageing Research Reviews
- A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heartPablo Ranea‐Robles, Natalya N. Pavlova, Aaron S. Bender, Andrea S. Pereyra, Jessica Mary Ellis, Brandon B. Stauffer, Chunli Yu, Craig B. Thompson, Carmen Argmann, Michelle A. Puchowicz et al. · 2022 · Cardiovascular Research
- Integrated Functions of Cardiac Energetics, Mechanics, and Purine Nucleotide MetabolismRachel Lopez‐Schenk, Nicole L. Collins, Noah A. Schenk, Daniel Andrew Beard · 2023 · Comprehensive physiology
- Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responsesAngelo Y. Meliton, Kun Woo D Shin, Rengül Çetin-Atalay, Volkan Atalay, Yufeng Tian, Jennifer C. Houpy Szafran, Takugo Cho, Kaitlyn A. Sun, Parker S. Woods, Obada R. Shamaa et al. · 2025 · Nature Communications
- Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and ProliferationTommy Weiss‐Sadan, Gal Itzhak, Farnusch Kaschani, Zhanru Yu, Mohamed Mahameed, Adi Anaki, Yael Ben‐Nun, Emmanuelle Merquiol, Boaz Tirosh, Benedikt Mathias Kessler et al. · 2019 · Molecular & Cellular Proteomics
- A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stressHans M. Dalton, Raghuvir Viswanatha, Roderick Brathwaite, Jae Sophia Zuno, Alexys R. Berman, Rebekah Rushforth, Stephanie Elizabeth Mohr, Norbert Perrimon, Clement Y. Chow · 2022 · PLoS Genetics
- mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotectionOlha Kostiuchenko, Iryna Lushnikova, Magdalena Kowalczyk, G. G. Skibo · 2022 · BBA Advances
- Evaluating everolimus for the treatment of breast cancerCamille Moreau-Bachelard, Marie Robert, Carole Gourmelon, Emmanuelle Bourbouloux, Anne Patsouris, Jean‐Sébastien Frenel, Mario Campone · 2023 · Expert Opinion on Pharmacotherapy
- SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasisSarah A. Tucker, Song-Hua Hu, Sejal Vyas, Albert Park, Shakchhi Joshi, Aslihan Inal, Tiffany Lam, Emily Tan, Kevin M. Haigis, Marcia C. Haigis · 2024 · Cell Reports
- Interplay between mTOR and Purine Metabolism Enzymes and Its Relevant Role in CancerS. Allegrini, Marcella Camici, Mercedes Garcia‐Gil, Rossana Pesi, Maria Grazia Tozzi · 2024 · International Journal of Molecular Sciences
- Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in lymphangioleiomyomatosisLeonardo Bottolo, Suzanne Miller, Simon R. Johnson · 2020 · Thorax
- Understanding the molecular mechanisms and role of autophagy in obesityTapan Behl, Aayush Sehgal, Rajni Bala, Swati Chadha · 2021 · Molecular Biology Reports
- Clinical Insights into Mitochondrial Neurodevelopmental and Neurodegenerative Disorders: Their Biosignatures from Mass Spectrometry-Based MetabolomicsHaorong Li, Martine N. Uittenbogaard, Ling Hao, Anne Chiaramello · 2021 · Metabolites
- Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical InsightsMd. Takdir Hossain, Md. Arafat Hossain · 2025 · Drug development research (Print)
- A coordinated multiorgan metabolic response contributes to human mitochondrial myopathyNneka Southwell, Guido Primiano, Viraj Nadkarni, Nabeel Attarwala, Emelie Beattie, Dawson Miller, Sumaitaah Alam, Irene Liparulo, Yevgeniya I. Shurubor, Maria Lucia Valentino et al. · 2023 · EMBO Molecular Medicine
- The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced LongevityLeah E. Jamerson, Patrick C. Bradshaw · 2024 · Antioxidants
- Purinosomes spatially co-localize with mitochondrial transportersZhou Sha, Stephen J. Benkovic · 2024 · Journal of Biological Chemistry
- mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers.Fuxia Li, Ensong Guo, Jia Ming Huang, Funian Lu, Bin Yang, Rourou Xiao, Chen Liu, Xue Yan Wu, Yu Fu, Zizhuo Wang et al. · 2020 · PubMed Central
- A two-front nutritional environment fuels colorectal cancer: perspectives for dietary interventionElien Alderweireldt, Charlotte Grootaert, Olivier De Wever, John Van Camp · 2021 · Trends in Endocrinology and Metabolism
- Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complexJames McKenna, David Kapfhamer, Jason Michael Kinchen, Brandi L. Wasek, Matthew Dunworth, Tracy Murray Stewart, Teodoro Bottiglieri, Robert A. Casero, Michael J. Gambello · 2018 · Human Molecular Genetics
- NRF3 activates mTORC1 arginine-dependently for cancer cell viabilityHirose, Shuuhei, Waku, Tsuyoshi, Tani, Misato, Masuda, Haruka, Endo, Keiko, Ashitani, Sanae, Aketa, Iori, Kitano, Hina, Nakada, Sota, Wada, Ayaka et al. · 2023 · iScience
- Modulation of the de novo purine nucleotide pathway as a therapeutic strategy in mitochondrial myopathySammy Kimoloi · 2018 · Pharmacological Research
- Ovine conceptus tissue metabolizes fructose for metabolic support during the peri-implantation period of pregnancyRobyn M Moses, Katherine M Halloran, Claire Stenhouse, Nirvay Sah, Avery C. Kramer, Bryan A McLendon, Heewon Seo, Gregory A. Johnson, Guoyao Wu, Fuller W. Bazer · 2022 · Biology of Reproduction
- High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevityBrenda González, Archana Tare, Seungjin Ryu, Simon C. Johnson, Gil Atzmon, Nir Barzilai, Matt R. Kaeberlein, Yousin Suh · 2022 · GeroScience
- Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signallingHuiwu Geng, Cheng Feng, Zhangran Sun, Fan Xu, Yiqing Xie, Jinghua Gu, Libin Fan, Gang Liu, Chao Li, Rick Francis Thorne et al. · 2022 · Translational Oncology
- Known types of membrane-less organelles and biomolecular condensatesApril L. Darling, Vladimir Nikolaevich Uversky · 2022 · Elsevier eBooks
- Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1Heng Du, Yu Chi Yang, Heng-Jia Liu, Min Yuan, John M. Asara, Kwok‐Kin Wong, Elizabeth P. Henske, Mallika Singh, David J. Kwiatkowski · 2023 · Journal of Clinical Investigation
- Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus responseEmilia Alors‐Pérez, Sergio Pedraza‐Arévalo, Ricardo Blázquez‐Encinas, Víctor García‐Vioque, Antonio Agraz-Doblás, Elena M. Yubero‐Serrano, Marina Sánchez‐Frías, Raquel Serrano‐Blanch, María Ángeles Gálvez-Moreno, Francisco Gracia‐Navarro et al. · 2023 · Molecular Therapy — Nucleic Acids
- Genome‐scale CRISPR–Cas9 screen identifies PAICS as a therapeutic target for EGFR wild‐type non‐small cell lung cancerYufeng Li, Lingyun Zhu, Jiaqi Mao, Hongrui Zheng, Ziyi Hu, Suisui Yang, Tianyu Mao, Tingting Zhou, Pingping Cao, Hongshuai Wu et al. · 2024 · MedComm
- Lysosomes in nutrient signalling: A focus on pancreatic β‐cellsGergő Mészáros, Adrien Pasquier, Kevin Vivot, Alexander Goginashvili, Roméo Ricci · 2018 · Diabetes Obesity and Metabolism
- mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic InsightsHsin-Sung Yeh, Jeongsik Yong · 2020 · Journal of Lipid and Atherosclerosis
- Pregnancy recognition signals in mammals: the roles of interferons and estrogensFuller W. Bazer, Guoyao Wu, Greg A. Johnson · 2016 · Animal Reproduction
- Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasiaOro Uchenunu, Michaël Pollak, Ivan Topisirović, Laura Hulea · 2018 · Journal of Molecular Endocrinology
- IsoSearch: An Untargeted and Unbiased Metabolite and Lipid Isotopomer Tracing Strategy from HR-LC-MS/MS DatasetsHe Huang, Min Yuan, Phillip Seitzer, Susan Ludwigsen, John M. Asara · 2020 · Methods and Protocols
- Regulation of Gene Expression by Amino Acids in Animal CellsNirvay Sah, Guoyao Wu, Fuller W. Bazer · 2021 · Advances in experimental medicine and biology
- Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesisLianxuan Liu, Mi Shao, Yue Huang, Pengxu Qian, He Huang · 2024 · Journal of Hematology & Oncology
- ERK Inhibitor Enhances Everolimus Efficacy through the Attenuation of dNTP Pools in Renal Cell CarcinomaYun Zou, Wenzhi Li, Juan Zhou, Jin Zhang, Yong Huang, Zhong Wang · 2019 · Molecular Therapy — Nucleic Acids
- Absence of Significant Off-Target Splicing Variation with a U7snRNA Vector Targeting DMD Exon 2 DuplicationsNicolas Wein, Diane Marie Dunn, Megan A. Waldrop, Liubov V. Gushchina, Emma C. Frair, Robert B. Weiss, Kevin M. Flanigan · 2021 · Human Gene Therapy
- A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesisXiaoguang Chen, Sang‐Hoon Kim, Sangkee Rhee, Claus‐Peter Witte · 2022 · The Plant Cell
- Mitochondrial translation factors reflect coordination between organelles and cytoplasmic translation via mTOR signaling: Implication in diseaseXintao Cao, Yan Qin · 2016 · Free Radical Biology and Medicine
- Serine Metabolism Links Tumor Suppression to the Epigenetic LandscapeXia Gao, Jason W. Locasale · 2016 · Cell Metabolism
- Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic TargetsAgnieszka Dominiak, Beata Chełstowska, Grażyna Nowicka · 2025 · Cancers
- PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversificationVerónica Delgado-Benito, Maria Berruezo-Llacuna, Robert Altwasser, Wiebke Winkler, Devakumar Sundaravinayagam, Sandhya Balasubramanian, Marieta Cagánová, Robin Graf, Ali Rahjouei, Marie‐Thérèse Henke et al. · 2020 · The Journal of Experimental Medicine
- Metabolic Hallmarks for Purine Nucleotide Biosynthesis in Small Cell Lung CarcinomaSho Tabata, Shigeki Umemura, Miyu Narita, Hibiki Udagawa, Takamasa Ishikawa, Masahiro Tsuboi, Kōichi Goto, Genichiro Ishii, Katsuya Tsuchihara, Atsushi Ochiai et al. · 2023 · Molecular Cancer Research
- Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression.Yitao Wang, T. Engel, Xinchen Teng · 2024 · Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
- Nuclear localization of MTHFD2 is required for correct mitosis progressionNatalia Pardo Lorente, Anestis Gkanogiannis, Luca Cozzuto, Antoni Gañez Zapater, Lorena Espinar, Ritobrata Ghose, Jacqueline Severino, Laura García-López, Rabia Gül Aydin, Laura Martin et al. · 2024 · Nature Communications
- Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeastMasak Takaine, Rikuri Morita, Yuto Yoshinari, Takashi Nishimura · 2025 · PLoS Biology
- Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitorMei‐Ping Chang, Steven C. Huhn, Luke Nelson, Michael J. Betenbaugh, Zhimei Du · 2022 · Biotechnology and Bioengineering
- Ait1 regulates TORC1 signaling and localization in budding yeastRyan L. Wallace, Erick Lu, Xiang-Xia Luo, A. Capaldi · 2022 · eLife
- ATM inhibition drives metabolic adaptation via induction of macropinocytosisZhentai Huang, Chi‐Wei Chen, Raquel Buj, Naveen Kumar Tangudu, Richard S. Fang, Kelly E. Leon, Erika S. Dahl, Erika L. Varner, Eliana V. von Krusenstiern, Aidan R. Cole et al. · 2022 · The Journal of Cell Biology
- Synergistic targeting of CHK1 and mTOR in MYC-driven tumorsXiaoxue Song, Liyuan Wang, Tianci Wang, Juncheng Hu, Jingchao Wang, Rongfu Tu, Hexiu Su, Jue Jiang, Guoliang Qing, Hudan Liu · 2020 · Carcinogenesis
- Metabolic Phenotypes, Dependencies, and Adaptation in Lung CancerGina M. DeNicola, David B. Shackelford · 2021 · Cold Spring Harbor Perspectives in Medicine
- Emerging roles for integrated stress response signaling in homeostasisShyama Nandakumar, Lydia Grmai, Deepika Vasudevan · 2025 · FEBS Journal
- Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytesHeng Wu, Betsy T. Kren, Andrew N. Lane, Teresa Cassel, Richard M. Higashi, Teresa W.‐M. Fan, George S. Scaria, Laurie L. Shekels, Mark Alan Klein, Jeffrey H. Albrecht · 2023 · Journal of Biological Chemistry
- Purinosomes and Purine Metabolism in Mammalian Neural Development: A ReviewSeiya Yamada, Tomoya Mizukoshi, Ayaka Sato, Shin‐ichi Sakakibara · 2024 · ACTA HISTOCHEMICA ET CYTOCHEMICA
- Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesisJinoh Kim, Kerui Huang, Pham Thuy Tien Vo, Ting Miao, Jacinta Correia, Ankur Kumar, Mirre J. P. Simons, Hua Bai · 2024 · PNAS Nexus