mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J. H., Asara, John M., Manning, Brendan D.·2016·Science

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Items 101–200 of 807

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  2. Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming
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  3. Ancillary Activity: Beyond Core Metabolism in Immune Cells
    Daniel J. Puleston, Matteo Villa, Erika L. Pearce · 2017 · Cell Metabolism
  4. Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
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  5. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
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    G. Napolitano, Chiara Di Malta, A. Ballabio · 2022 · Trends in Cell Biology
  10. mTOR: A Cellular Regulator Interface in Health and Disease
    Fahd Boutouja, Christian M. Stiehm, Harald W. Platta · 2019 · Cells
  11. Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR
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  14. Roles of mTOR Signaling in Tissue Regeneration
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  15. New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response
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  16. Role of mTORC1 in mechanically induced increases in translation and skeletal muscle mass
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  17. Cross-talk between protein synthesis, energy metabolism and autophagy in cancer
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  19. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
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  22. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
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  29. Pleiotropic Effects of mTOR and Autophagy During Development and Aging
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  30. The integrated stress response in metabolic adaptation
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    Erika Ilagan, B. Manning · 2016 · Trends in Cancer
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  43. In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  48. Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes
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  49. Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway
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  55. Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence
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  56. Immunometabolism of Phagocytes During Mycobacterium tuberculosis Infection
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  57. Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells
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  58. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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