mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J. H., Asara, John M., Manning, Brendan D.·2016·Science

Cited by (807)

Items 801–807 of 807

  1. A Novel ACLY Inhibitor Induces Transcriptional and Metabolic Reprogramming to Overcome Tyrosine kinase inhibitor Resistance in Lymphoma
    Nagarajan Pattabiraman, Cosimo Lobello, David Rushmore, Shengchun Wang, Luca Mologni, Hossein Borgh, Kavindra Nath, Wujuan Zhang, Aaron R. Goldman, Reza Nejati et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Experimental approaches for linking purinosome spatial organization to metabolic function
    Zhou Sha, Jingxuan He, Stephen J. Benkovic · 2026 · Methods in enzymology on CD-ROM/Methods in enzymology
  3. PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia
    Rayees Ahmad Padder, Le Le, Emily Hyde, Maria Elena Diaz-Rubio, Eric N. Chiles, Jay N. Joshi, Nanda Singh, Masuda Akther, Namratha Sheshadri, Kelly Mulraney et al. · 2026 · EMBO Molecular Medicine
  4. XDH Inhibits the Progression of Colorectal Cancer via Regulating Ferritinophagy Signaling
    Hui Zhang, Meimei Yan, Mengya Li, Junjiao Gu, Xintao Wang, Jin Ding, Suxia Luo · 2026 · Journal of Biochemical and Molecular Toxicology
  5. BindingDB Entry 50018379: Research progress of mTOR inhibitors.
    BindingDB · 2024 · UC San Diego
  6. HIF-1α deficiency impairs mandibular condylar osteochondral maturation and triggers progenitor hyperproliferation via dysregulated mTOR-cytoophidia dynamics
    Q. Zhang, Miaomiao Bie, PAN Chaoqun, Yuxing Xia, Mengmeng Jin, Rong Cong, Feiwu Kang, Yi Tang · 2026 · Osteoarthritis and Cartilage
  7. Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism
    Kelly Rome, Elise Hall, Tran Ngoc Van Le, Alison Jaccard, Aaron Wu, Nathaniel W. Snyder, Kathryn E. Wellen, Will Bailis · 2026 · EMBO Reports