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Phase separation of signaling molecules promotes T cell receptor signal transduction
Open accessAbstract
Phase separation organizes signaling: In T cell receptors, signaling molecules reorganize into tiny phase-separated droplets—like oil in water. Su et al. used an in vitro system with artificial membranes and 12 components of the T cell receptor signaling system to closely monitor the role of these molecular clusters (see the Perspective by Dustin and Muller). The clusters formed through phosphorylation-dependent association of the linker protein LAT (linker for activation of T cells) with other proteins. These clusters also managed to exclude an inactivating phosphatase and increased the specific activity of enzymes controlling actin polymerization. Science , this issue p. 595 ; see also p. 516
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Metadata
- Authors
- Su, X., Ditlev, J. A., Hui, E., Xing, W., Banjade, S., Okrut, J., King, D. S., Taunton, J., Rosen, M. K., & Vale, R. D.
- Venue
- Science
- Published
- 2016-04-29
- Volume
- 352
- Issue
- 6285
- Pages
- 595-599
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2335345046
- Cited by
- 1,246
- References
- 0
- FWCI
- 36.72
- Type
- journal article
- Language
- en
- Open access
- green
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