Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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    In-Young Jung, Vivek Narayan, Sierra McDonald, Andrew J. Rech, Robert L. Bartoszek, Gwanui Hong, Megan M. Suhoski, Jun Xu, Alina C. Boesteanu, Julie S. Barber-Rotenberg et al. · 2022 · Science Translational Medicine
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    Mary Philip, Andrea Schietinger · 2019 · Current Opinion in Immunology
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    Kevin Wang, Paulina Coutifaris, David Brocks, Guanning Wang, Tarek Azar, Sabrina Solis, Ajeya Nandi, Shaneaka Anderson, Nicholas A. Han, Sasikanth Manne et al. · 2024 · Cancer Cell
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    Zhi Li, Zewen Kelvin Tuong, Isaac Dean, Claire Willis, Fabrina Gaspal, Rémi Fiancette, Suaad Idris, Bethany C. Kennedy, John R. Ferdinand, Ana Peñalver et al. · 2022 · The Journal of Experimental Medicine
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    Andrew R. DiNardo, Kimal Rajapakshe, Tomoki Nishiguchi, Sandra L. Grimm, Godwin Mtetwa, Qiniso Dlamini, Jaqueline Kahari, Sanjana Mahapatra, Alexander W. Kay, Gugu P. Maphalala et al. · 2020 · Journal of Clinical Investigation
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    Julie Niogret, Hélène Berger, Cédric Rébé, Romain Mary, Elise Ballot, Caroline Truntzer, Marion Thibaudin, Valentin Dérangère, Christophe Hibos, Léa Hampe et al. · 2021 · Journal for ImmunoTherapy of Cancer
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    Shin Foong Ngiow, Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew, Qingzhou Chen, Omar Khan, Jennifer E. Wu, Víctor Alcalde et al. · 2024 · Cell
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