Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu +11 more·2016·Science

Cited by (1,000)

Items 101–200 of 1,000

  1. T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
    Alireza Saeidi, Keivan Zandi, Yi Ying Cheok, Hamidreza Saeidi, Won Fen Wong, Chalystha Yie Qin Lee, Heng Choon Cheong, Yean Kong Yong, Marie Larsson, Esaki Muthu Shankar · 2018 · Frontiers in Immunology
  2. Cancer Epigenetics, Tumor Immunity, and Immunotherapy
    Jian Cao, Qin Yan · 2020 · Trends in Cancer
  3. Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity
    Prinzing, Brooke, Zebley, Caitlin C., Petersen, Christopher T., Fan, Yiping, Anido, Alejandro Allo, Yi, Zhongzhen, Nguyen, Phuong, Houke, Haley, Bell, Matthew, Haydar, Dalia et al. · 2021 · Science Translational Medicine
  4. Acetate Promotes T Cell Effector Function during Glucose Restriction
    Qiu, Jing, Villa, Matteo, Sanin, David E., Buck, Michael D., O’Sullivan, David, Ching, Reagan, Matsushita, Mai, Grzes, Katarzyna M., Winkler, Frances, Chang, Chih-Hao et al. · 2019 · Cell Reports
  5. Understanding the tumor microenvironment for effective immunotherapy
    Sadeghi Rad, Habib, Monkman, James, Warkiani, Majid E., Ladwa, Rahul, O'Byrne, Ken, Rezaei, Nima, Kulasinghe, Arutha · 2021 · Medicinal Research Reviews
  6. Principles and therapeutic applications of adaptive immunity
    Hongbo Chi, Marion Pepper, Paul Glyndwr Thomas · 2024 · Cell
  7. Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
    Weiqin Jiang, Yinjun He, Wenguang He, Guosheng S. Wu, Xile Zhou, Qinsong Sheng, Weixiang Zhong, Yimin Lu, Yongfeng Ding, Lu Qi et al. · 2021 · Frontiers in Immunology
  8. T Cell Dysfunction in Cancer Immunity and Immunotherapy
    Anliang Xia, Yan Zhang, Xu Jiang, Tailang Yin, Xiaojie Lu · 2019 · Frontiers in Immunology
  9. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans
    Galletti, Giovanni, De Simone, Gabriele, Mazza, Emilia M. C., Puccio, Simone, Mezzanotte, Claudia, Bi, Timothy M., Davydov, Alexey N., Metsger, Maria, Scamardella, Eloise, Alvisi, Giorgia et al. · 2020 · Nature Immunology
  10. Microenvironmental Determinants of Pancreatic Cancer
    Elisabeth Heßmann, S Buchholz, İhsan Ekin Demir, Shiv K. Singh, Thomas Mathias Gress, Volker Ellenrieder, Albrecht Neeße · 2020 · Physiological Reviews
  11. NK Cell Exhaustion
    Jiacheng Bi, Zhigang Tian · 2017 · Frontiers in Immunology
  12. PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
    Masao Hashimoto, Koichi Araki, Maria Andrea Cardenas, Peng Li, Rohit R. Jadhav, Haydn Thomas Kissick, William H. Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland et al. · 2022 · Nature
  13. Epigenetic regulation of T cell exhaustion
    Julia A. Belk, Bence Dániel, Ansuman T. Satpathy · 2022 · Nature Immunology
  14. Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer
    Clémence Granier, Éléonore De Guillebon, Charlotte Blanc, Helene Roussel, Cécile Badoual, Elia Colin, Antonin Saldmann, Alain Gey, Stéphane Marie. Oudard, Éric Tartour · 2017 · ESMO Open
  15. Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40
    David J. Messenheimer, Shawn M. Jensen, Michael E. Afentoulis, Keith W. Wegmann, Zipei Feng, David J. Friedman, Michael J. Gough, Walter John Urba, Bernard A. Fox · 2017 · Clinical Cancer Research
  16. Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
    Bertram Bengsch, Takuya Ohtani, Omar Khan, Manu N. Setty, Sasikanth Manne, Shaun O’Brien, Pier Federico Gherardini, Ramin S. Herati, Alexander Chan Chi Huang, Kyong‐Mi Chang et al. · 2018 · Immunity
  17. Early precursor T cells establish and propagate T cell exhaustion in chronic infection
    Daniel T. Utzschneider, Sarah S. Gabriel, David Chisanga, Renee Gloury, Patrick M. Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies · 2020 · Nature Immunology
  18. Exhaustion-associated regulatory regions in CD8 + tumor-infiltrating T cells
    Giuliana P. Mognol, Roberto Spreafico, Victor Wong, James P Scott-Browne, Susan Togher, Alexander Hoffmann, Patrick G. Hogan, Anjana Rao, Sara Trifari · 2017 · Proceedings of the National Academy of Sciences
  19. CD8+ T cell exhaustion
    Makoto Kurachi · 2019 · Seminars in Immunopathology
  20. Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction
    Singh, Nathan, Lee, Yong Gu, Shestova, Olga, Ravikumar, Pranali, Hayer, Katharina E., Hong, Seok Jae, Lu, Xueqing Maggie, Pajarillo, Raymone, Agarwal, Sangya, Kuramitsu, Shunichiro et al. · 2020 · Cancer Discovery
  21. Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression
    Saleh, Reem, Elkord, Eyad · 2020 · Seminars in Cancer Biology
  22. Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
    Weimin Wang, Weiping Zou · 2020 · Molecular Cell
  23. TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma
    Wang, Xiaochen, He, Qifeng, Shen, Haiyuan, Xia, Anliang, Tian, Wenfang, Yu, Weiwei, Sun, Beicheng · 2019 · Journal of Hepatology
  24. AP-1 Transcription Factors as Regulators of Immune Responses in Cancer
    Vassilios Atsaves, Vasiliki Leventaki, George Z. Rassidakis, Francois X. Claret · 2019 · Cancers
  25. Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
    Anthony T. Phan, Ananda W. Goldrath, Christopher K. Glass · 2017 · Immunity
  26. PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
    Zijun Yidan Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H. Young · 2017 · Frontiers in Immunology
  27. Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes
    Jason M. Schenkel, Rebecca H. Herbst, David A. Canner, Amy Li, Michelle Hillman, Sean-Luc Shanahan, Grace Gibbons, Olivia C. Ghirardelli Smith, Jonathan Y. Kim, Peter M.K. Westcott et al. · 2021 · Immunity
  28. The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth
    Lihui Dong, Chuanyuan Chen, Yawei Zhang, Peijin Guo, Zhenghang Wang, Jian Li, Yi Liu, Jun Liu, Renbao Chang, Yilin Li et al. · 2021 · Cancer Cell
  29. Epigenetic control of innate and adaptive immune memory
    Colleen M. Lau, Nicholas M. Adams, Clair D. Geary, Orr-El Weizman, Moritz Rapp, Yuri Pritykin, Christina S. Leslie, Joseph Chai-Yuen Sun · 2018 · Nature Immunology
  30. The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance
    Günther Schönrich, Martin J. Raftery · 2019 · Frontiers in Cellular and Infection Microbiology
  31. Rethinking peripheral T cell tolerance: checkpoints across a T cell’s journey
    Mohamed A. ElTanbouly, Randolph J. Noelle · 2020 · Nature reviews. Immunology
  32. Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
    Giles, Josephine R., Ngiow, Shin Foong, Manne, Sasikanth, Baxter, Amy E., Khan, Omar, Wang, Ping, Staupe, Ryan, Abdel-Hakeem, Mohamed S., Huang, Hua, Mathew, Divij et al. · 2022 · Nature Immunology
  33. Glioblastoma Therapy: Past, Present and Future
    Elena Obrador, Paz Moreno-Murciano, María Oriol‐Caballo, Rafael López‐Blanch, Begoña Pineda, Julia Gutiérrez-Arroyo, Alba Loras, Luis Germán González Bonet, Conrado Martínez‐Cadenas, José M. Estrela et al. · 2024 · International Journal of Molecular Sciences
  34. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
    Mohamed S. Abdel-Hakeem, Sasikanth Manne, Jean‐Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha, Mohammed-Alkhatim Ali, John L. Johnson, Josephine Ruth Giles, Divij Mathew et al. · 2021 · Nature Immunology
  35. PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients
    Aung Naing, Jeffrey R. Infante, Kyriakos P. Papadopoulos, Ivan H. Chan, Cong Shen, Navneet P. Ratti, Bianca Rojo, Karen A. Autio, Deborah J. L. Wong, Manish R. Patel et al. · 2018 · Cancer Cell
  36. Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
    Kathleen B. Yates, Pierre Tonnerre, Genevieve Elizabeth Martin, Ulrike Gerdemann, Rose Al Abosy, Dawn E. Comstock, Sarah A. Weiss, David Wolski, Damien C. Tully, Raymond T. Chung et al. · 2021 · Nature Immunology
  37. Nanomaterials in tumor immunotherapy: new strategies and challenges
    Xudong Zhu, Shenglong Li · 2023 · Molecular Cancer
  38. PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
    Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe, Brian C. Miller, Kathleen B. Yates, Jacob E. Gillis, Debattama R. Sen, Emily F. Gaudiano, Rose Al Abosy, Gordon James Freeman et al. · 2019 · Nature Immunology
  39. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment
    Nandini Acharya, Asaf Madi, Huiyuan Zhang, Max Klapholz, Giulia Escobar, Shai Dulberg, Elena Christian, Michelle Ferreira, Karen Olivia Dixon, Geoffrey G. Fell et al. · 2020 · Immunity
  40. Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
    Collier, Jenna L., Weiss, Sarah A., Pauken, Kristen E., Sen, Debattama R., Sharpe, Arlene H. · 2021 · Nature Immunology
  41. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
    Chaofan Li, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, Kathryn Eby Beckermann, Yue Wu, James W. Jenkins et al. · 2019 · Immunity
  42. PD-1/PD-L1 checkpoint inhibitors in advanced hepatocellular carcinoma immunotherapy
    Qian Li, Jingjing Han, Yonglin Yang, Yu Chen · 2022 · Frontiers in Immunology
  43. Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells
    Masahiro Okada, Shunsuke Chikuma, Taisuke Kondo, Sana Hibino, Hiroaki Machiyama, Tadashi Yokosuka, Miyako Nakano, Akihiko Yoshimura · 2017 · Cell Reports
  44. The Immune Microenvironment in Pancreatic Cancer
    Magdalena Huber, Corinna U. Brehm, Thomas Mathias Gress, Malte Buchholz, Bilal Alashkar Alhamwe, Elke Pogge von Strandmann, Emily P. Slater, Jörg Walter Bartsch, Christian Alexander Bauer, Matthias Lauth · 2020 · International Journal of Molecular Sciences
  45. Cellular networks controlling T cell persistence in adoptive cell therapy
    Jack D. Chan, Junyun Lai, Clare Y. Slaney, Axel Kallies, Paul A. Beavis, Phillip Kevin Darcy · 2021 · Nature reviews. Immunology
  46. RASA2 ablation in T cells boosts antigen sensitivity and long-term function
    Julia C. Carnevale, Eric Shifrut, Nupura Kale, William A. Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P. Bapat, Morgan E. Diolaiti, Patrick C. O’Leary et al. · 2022 · Nature
  47. Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy
    David Mark Francis, Margaret Patricia Manspeaker, Alex Schudel, Lauren F. Sestito, Meghan J. O’Melia, Haydn Thomas Kissick, Brian P. Pollack, Edmund K. Waller, Susan Napier Thomas · 2020 · Science Translational Medicine
  48. TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells
    Takuya Sekine, André Perez‐Potti, Son Nguyen, Jean‐Baptiste Gorin, Vincent H. Wu, Emma Gostick D, Sian Llewellyn‐Lacey, Quirin Hammer, Sara Falck‐Jones, Sindhu Vangeti et al. · 2020 · Science Immunology
  49. The Contribution of Epigenetics to Cancer Immunotherapy
    Lorea Villanueva, Damiana Álvarez‐Errico, Manel Esteller · 2020 · Trends in Immunology
  50. Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma
    Yana George Najjar, Ashley V. Menk, Cindy Sander, Uma N. M. Rao, Arivarasan D. Karunamurthy, Roma Bhatia, Shuyan Zhai, John M. Kirkwood, Greg M. Delgoffe · 2019 · JCI Insight
  51. Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
    Yao Wang, Chuan Tong, Hanren Dai, Zhiqiang Wu, Xiao Han, Yelei Guo, Deyun Chen, Jianshu Wei, Dongdong Ti, Zongzhi Z. Liu et al. · 2021 · Nature Communications
  52. Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes
    Marco Antonio Moro‐García, Juan C. Mayo, Rosa María Sainz, Rebeca Alonso‐Arias · 2018 · Frontiers in Immunology
  53. ‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses
    Dietmar Zehn, Robert Thimme, Enrico Lugli, Gustavo Pereira de Almeida, Annette Oxenius · 2022 · Nature Immunology
  54. Divergent clonal differentiation trajectories of T cell exhaustion
    Bence Dániel, Kathryn E. Yost, Sunnie Hsiung, Katalin D. Sandor, Yu Xia, Yanyan Qi, Kamir J. Hiam-Galvez, Mollie Black, Colin J. Raposo, Quanming Shi et al. · 2022 · Nature Immunology
  55. Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells
    Johnson, John L., Georgakilas, Georgios, Petrovic, Jelena, Kurachi, Makoto, Cai, Stanley, Harly, Christelle, Pear, Warren S., Bhandoola, Avinash, Wherry, E. John, Vahedi, Golnaz · 2018 · Immunity
  56. Overcoming Immune Evasion in Melanoma
    Kevinn Eddy, Suzie Chen · 2020 · International Journal of Molecular Sciences
  57. High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells
    Jing Li, Yi He, Jing Hao, Ling Ni, Chen Dong · 2018 · Frontiers in Immunology
  58. Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming
    Bénéchet, Alexandre P., De Simone, Giorgia, Di Lucia, Pietro, Cilenti, Francesco, Barbiera, Giulia, Le Bert, Nina, Fumagalli, Valeria, Lusito, Eleonora, Moalli, Federica, Bianchessi, Valentina et al. · 2019 · Nature
  59. De novo design of protein logic gates
    Zibo Chen, Ryan D. Kibler, Andrew C. Hunt, Florian Büsch, Jocelynn R. Pearl, Mengxuan Jia, Zachary L. VanAernum, Basile I. M. Wicky, Galen Dods, Hanna Liao et al. · 2020 · Science
  60. Addition of Low-Dose Decitabine to Anti–PD-1 Antibody Camrelizumab in Relapsed/Refractory Classical Hodgkin Lymphoma
    Jing Nie, Chunmeng Wang, Yang Liu, Qingming Yang, Qian Mei, Liang Dong, Xiang Li, Jiejie Liu, Wenjing Ku, Yan Zhang et al. · 2019 · Journal of Clinical Oncology
  61. PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
    Rémi Fromentin, Sandrina DaFonseca, Cecilia Theresa Costiniuk, Mohamed El Far, Francesco A. Procopio, Frederick M. Hecht, Rebecca Hoh, Steven G. Deeks, Daria J. Hazuda, Sharon R. Lewin et al. · 2019 · Nature Communications
  62. Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
    Liangliang Xu, Chang Zou, Shanshan Zhang, Timothy Shun Man Chu, Yan Zhang, Weiwei Chen, Cai‐Ning Zhao, Yang Li, Zhiyuan Xu, Shaowei Dong et al. · 2022 · Journal of Hematology & Oncology
  63. T cell factor 1: A master regulator of the T cell response in disease
    Escobar, Giulia, Mangani, Davide, Anderson, Ana C. · 2020 · Science Immunology
  64. Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells
    Jing Li, Younghee Lee, Yanjian Li, Yu Yong Jiang, Huiping Lu, Wenjuan Zang, Xiaohong Zhao, Liguo Liu, Yang Chen, Haidong Tan et al. · 2018 · Immunity
  65. Cancer immunotherapy: it’s time to better predict patients’ response
    Charlotte Pilard, Marie Ancion, Philippe Delvenne, Guy Jérusalem, Pascale Hubert, Michael F. Herfs · 2021 · British Journal of Cancer
  66. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
    Si, Jingwen, Shi, Xiangjun, Sun, Shuhao, Zou, Bin, Li, Yaopeng, An, Dongjie, Lin, Xingyu, Gao, Yan, Long, Fei, Pang, Bo et al. · 2020 · Cancer Cell
  67. Future cancer research priorities in the USA: a Lancet Oncology Commission
    Elizabeth M. Jaffee, Chi Van Dang, David B. Agus, Brian Michael Alexander, Kenneth Carl Anderson, Alan Ashworth, Anna D. Barker, Roshan Bastani, Sangeeta N. Bhatia, Jeffrey A. Bluestone et al. · 2017 · The Lancet Oncology
  68. In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
    Zeyu Chen, Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan Ming He, Hua Huang, Sasikanth Manne, Zhendong Cao, Amy E. Baxter et al. · 2021 · Cell
  69. Role of PD-1 in Immunity and Diseases
    Kenji Chamoto, Muna Al-Habsi, Tasuku Honjo · 2017 · Current topics in microbiology and immunology
  70. BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
    Chen Yao, Guohua Lou, Hong‐Wei Sun, Ziang Zhu, Yi Eve Sun, Zeyu Chen, Daniel Chauss, E. Ashley Moseman, Jun Cheng, Marc A. D’Antonio et al. · 2021 · Nature Immunology
  71. Chromatin accessibility profiling methods
    Minnoye, Liesbeth, Marinov, Georgi K., Krausgruber, Thomas, Pan, Lixia, Marand, Alexandre P., Secchia, Stefano, Greenleaf, William J., Furlong, Eileen E. M., Zhao, Keji, Schmitz, Robert J. et al. · 2021 · Nature Reviews Methods Primers
  72. Anti–PD-L1 Treatment Results in Functional Remodeling of the Macrophage Compartment
    Huizhong Xiong, Stephanie Mittman, Ryan Rodriguez, Марина Москаленко, Patricia Pacheco-Sanchez, Yagai Yang, Dorothee Nickles, Rafael A. Cubas · 2019 · Cancer Research
  73. Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy
    Ma, Shijun, Zhao, Yue, Lee, Wee Chyan, Ong, Li-Teng, Lee, Puay Leng, Jiang, Zemin, Oguz, Gokce, Niu, Zhitong, Liu, Min, Goh, Jian Yuan et al. · 2022 · Nature Communications
  74. Study and analysis of antitumor resistance mechanism of PD1/PD‐L1 immune checkpoint blocker
    Zhengyi Wang, Xiaoying Wu · 2020 · Cancer Medicine
  75. Activation or exhaustion of CD8+ T cells in patients with COVID-19
    Min‐Seok Rha, Eui‐Cheol Shin · 2021 · Cellular and Molecular Immunology
  76. Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance
    Young‐Jun Park, Da‐Sol Kuen, Yeonseok Chung · 2018 · Experimental & Molecular Medicine
  77. Emerging concepts in PD-1 checkpoint biology
    Kristen E. Pauken, James Anthony Torchia, Apoorvi Chaudhri, Arlene H. Sharpe, Gordon James Freeman · 2021 · Seminars in Immunology
  78. Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
    Hui Yi Chew, Priscila Oliveira de Lima, Jazmina L. Gonzalez Cruz, Blerida Banushi, G O Echejoh, Lingbo Hu, Shannon R. Joseph, Benedict Lum, James Rae, Jake S. O’Donnell et al. · 2020 · Cell
  79. Tumor immunotherapy resistance: Revealing the mechanism of PD-1 / PD-L1-mediated tumor immune escape
    Jiawen Cui, Yao Li, Yang Yang, Hai‐Kui Yang, Jia-Mei Dong, Zhi-Hua Xiao, Xin He, Jiahao Guo, Ruiqi L. Wang, Bo Dai et al. · 2024 · Biomedicine & Pharmacotherapy
  80. The Promise of Neoadjuvant Immunotherapy and Surgery for Cancer Treatment
    Jake S. O’Donnell, Esmée P. Hoefsmit, Mark John Smyth, Christian U. Blank, Michele W.L. Teng · 2019 · Clinical Cancer Research
  81. Adaptation and memory in immune responses
    Gioacchino Natoli, Renato Ostuni · 2019 · Nature Immunology
  82. Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
    Chamoto, Kenji, Yaguchi, Tomonori, Tajima, Masaki, Honjo, Tasuku · 2023 · Nature Reviews Immunology
  83. The function and dysfunction of memory CD 8+ T cells in tumor immunity
    James L. Reading, Felipe Gálvez‐Cancino, Charles Swanton, Álvaro Lladser, Karl S. Peggs, Sergio A. Quezada · 2018 · Immunological Reviews
  84. BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection
    Yao Chen, Ryan Zander, Xiaopeng Wu, David Schauder, Moujtaba Y. Kasmani, Jian Shen, Shikan Zheng, Robert Burns, Elizabeth J. Taparowsky, Weiguo Cui · 2021 · Nature Immunology
  85. Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery
    Nidetz, Natalie F., McGee, Michael C., Tse, Longping V., Li, Chengwen, Cong, Le, Li, Yunxing, Huang, Weishan · 2020 · Pharmacology & Therapeutics
  86. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells
    Carmen M. Anadon, Xiaoqing Yu, Kay Hänggi, Subir Biswas, Ricardo A. Chaurio, Alexandra Martin, Kyle K. Payne, Gunjan Mandal, Patrick Innamarato, Carly M. Harro et al. · 2022 · Cancer Cell
  87. Inhibitors of the PD-1 Pathway in Tumor Therapy
    Martin W. LaFleur, Yuki Muroyama, Charles G. Drake, Arlene H. Sharpe · 2018 · The Journal of Immunology
  88. Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy
    Jii Bum Lee, Hye Ryun Kim, Sang‐Jun Ha · 2022 · Immune Network
  89. T follicular helper cells in human efferent lymph retain lymphoid characteristics
    Vella, Laura A., Buggert, Marcus, Manne, Sasikanth, Herati, Ramin S., Sayin, Ismail, Kuri-Cervantes, Leticia, Bukh Brody, Irene, O’Boyle, Kaitlin C., Kaprielian, Hagop, Giles, Josephine R. et al. · 2019 · Journal of Clinical Investigation
  90. Long-term reprogramming of the innate immune system
    Jorge Domínguez‐Andrés, Mihai Gheorghe Netea · 2018 · Journal of Leukocyte Biology
  91. The scientific basis of combination therapy for chronic hepatitis B functional cure
    Seng Gee Lim, Thomas F. Baumert, Carolina Boni, Ed J. Gane, Massimo Levrero, Anna Suk-Fong Lok, Mala K. Maini, Norah A. Terrault, Fabien Zoulim · 2023 · Nature Reviews Gastroenterology & Hepatology
  92. Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8 <sup>+</sup> T cell dysfunction and maintain memory phenotype
    Wang, Bei, Zhang, Wen, Jankovic, Vladimir, Golubov, Jacquelynn, Poon, Patrick, Oswald, Erin M., Gurer, Cagan, Wei, Joyce, Ramos, Ilyssa, Wu, Qi et al. · 2018 · Science Immunology
  93. Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically
    Shawn C. Chafe, Paul C. McDonald, Saeed Saberi, Oksana Nemirovsky, Geetha Venkateswaran, Samantha Burugu, Dongxia Gao, Alberto Delaidelli, Alastair Hugh Kyle, Jennifer H.E. Baker et al. · 2019 · Cancer Immunology Research
  94. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
    Yamamoto, Tori N., Lee, Ping-Hsien, Vodnala, Suman K., Gurusamy, Devikala, Kishton, Rigel J., Yu, Zhiya, Eidizadeh, Arash, Eil, Robert, Fioravanti, Jessica, Gattinoni, Luca et al. · 2019 · Journal of Clinical Investigation
  95. Pathogenetic Mechanisms of T Cell Dysfunction in Chronic HBV Infection and Related Therapeutic Approaches
    Paola Fisicaro, Valeria Barili, Marzia Rossi, Ilaria Montali, Andrea Lorenzo Vecchi, Greta Acerbi, Diletta Laccabue, Alessandra Zecca, Amalia Penna, Gabriele Missale et al. · 2020 · Frontiers in Immunology
  96. SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells
    Tom Li Stephen, Kyle K. Payne, Ricardo A. Chaurio, Michael J. Allegrezza, Hengrui Zhu, Jairo Pérez‐Sanz, Alfredo Perales‐Puchalt, Jenny M. Nguyen, Ana Vara-Ailor, Evgeniy B. Eruslanov et al. · 2017 · Immunity
  97. CD8+ T cell exhaustion and cancer immunotherapy
    Wang, Qingda, Qin, Yang, Li, Bo · 2023 · Cancer Letters
  98. Restoring, releasing or replacing adaptive immunity in chronic hepatitis B
    Mala K. Maini, Alice R. Burton · 2019 · Nature Reviews Gastroenterology & Hepatology
  99. Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity
    Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., John Wherry, E., Lipson, Evan J. et al. · 2020 · Nature Immunology
  100. Exhaustion of CAR T cells: potential causes and solutions
    Taku Kouro, Hidetomo Himuro, Tetsuro Sasada · 2022 · Journal of Translational Medicine