Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
Open accessAbstract
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)—as essential fuels supporting CD8 + T cell metabolism and effector function. βOHB directly increased CD8 + T effector (Teff) cell cytokine production and cytolytic activity, and KB oxidation (ketolysis) was required for Teff cell responses to bacterial infection and tumor challenge. CD8 + Teff cells preferentially used KBs over glucose to fuel the tricarboxylic acid (TCA) cycle in vitro and in vivo . KBs directly boosted the respiratory capacity and TCA cycle-dependent metabolic pathways that fuel CD8 + T cell function. Mechanistically, βOHB was a major substrate for acetyl-CoA production in CD8 + T cells and regulated effector responses through effects on histone acetylation. Together, our results identify cell-intrinsic ketolysis as a metabolic and epigenetic driver of optimal CD8 + T cell effector responses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In response to bacterial infection and tumor, ketone bodies enhanced respiratory capacity and TCA cycle-dependent metabolic pathways that support CD8+ T cell function.
“In response to bacterial infection and tumor, ketone bodies enhanced the respiratory capacity and tricarboxylic acid (TCA) cycle-dependent metabolic pathways that support CD8+ T cell function.”
From SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation (2024) · cites this paper as [13]
β-OHB influenced CD8+ T cell effector responses by affecting histone acetylation.
“β-hydroxybutyrate (β-OHB) served as a key substrate for acetyl-coenzyme A (CoA) production in CD8+ T cells and influenced their effector responses by affecting histone acetylation.13”
From SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation (2024) · cites this paper as [13]
β-hydroxybutyrate (β-OHB) served as a key substrate for acetyl-coenzyme A (CoA) production in CD8+ T cells.
“β-hydroxybutyrate (β-OHB) served as a key substrate for acetyl-coenzyme A (CoA) production in CD8+ T cells and influenced their effector responses by affecting histone acetylation.13”
From SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation (2024) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
Durinck, S., Spellman, P. T., Birney, E., & Huber, W. K. (2009) · Nature Protocols · doi:10.1038/nprot.2009.97 · Cited by 4,081 · see citing works
A guide to immunometabolism for immunologists
O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315 · see citing works
BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis
Durinck, S., Moreau, Y., Kasprzyk, A., Davis, S. R., Moor, B. D., Brāzma, A., & Huber, W. K. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti525 · Cited by 2,327 · see citing works
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204 · see citing works
Self-citationThe ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works
Self-citationSuppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777 · see citing works
The multifaceted roles of fatty acid synthesis in cancer
Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651 · see citing works
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics
Puchalska, P., & Crawford, P. A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.022 · Cited by 1,617 · see citing works
Self-citationFueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
Self-citationEpigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Pauken, K. E., Sammons, M. A., Odorizzi, P. M., Manne, S., Godec, J., Khan, O., Drake, A. M., Chen, Z., Sen, D. R., Kurachi, M., et al. (2016) · Science · doi:10.1126/science.aaf2807 · Cited by 1,348 · see citing works
GAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333 · see citing works
Cahill, G. F. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111258 · Cited by 1,318 · see citing works
Metabolic Instruction of Immunity
Buck, M. D., Sowell, R., Kaech, S. M., & Pearce, E. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.004 · Cited by 1,232 · see citing works
CD8+ T cell differentiation and dysfunction in cancer
Philip, M., & Schietinger, A. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00574-3 · Cited by 1,052 · see citing works
Effector and Memory CTL Differentiation
Williams, M. A., & Bevan, M. J. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141548 · Cited by 942 · see citing works
Chromatin states define tumour-specific T cell dysfunction and reprogramming
Philip, M., Fairchild, L., Sun, L., Horste, E. L., Camara, S., Shakiba, M., Scott, A. C., Viale, A., Lauer, P., Merghoub, T., et al. (2017) · Nature · doi:10.1038/nature22367 · Cited by 933 · see citing works
Szabo, P. A., Levitin, H. M., Miron, M., Snyder, M. E., Senda, T., Yuan, J., Cheng, Y. L., Bush, E. C., Dogra, P., Thapa, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12464-3 · Cited by 756 · see citing works
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie, Z., Zhang, D., Chung, D., Tang, Z., Huang, H., Dai, L., Qi, S., Li, J., Colak, G., Chen, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.036 · Cited by 744 · see citing works
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
Blagih, J., Coulombe, F., Vincent, E. E., Dupuy, F., Galicia-Vázquez, G., Yurchenko, E., Raissi, T. C., van der Windt, G. J. W., Viollet, B., Pearce, E. L., et al. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.030 · Cited by 659 · see citing works
Self-citationSerine is an essential metabolite for effector T cell expansion
Ma, E. H., Bantug, G., Griss, T., Condotta, S., Johnson, R. M., Samborska, B., Mainolfi, N., Suri, V., Guak, H., Balmer, M. L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.011 · Cited by 657 · see citing works
Self-citationCantor, J. R., Abu-Remaileh, M., Kanarek, N., Freinkman, E., Gao, X., Louissaint, A., Lewis, C. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.03.023 · Cited by 611 · see citing works
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell · doi:10.1016/j.cell.2016.07.026 · Cited by 579 · see citing works
Mookerjee, S. A., Gerencser, A. A., Nicholls, D. G., & Brand, M. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.774471 · Cited by 550 · see citing works
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
Ferrere, G., Tidjani Alou, M., Liu, P., Goubet, A.-G., Fidelle, M., Kepp, O., Durand, S., Iebba, V., Fluckiger, A., Daillère, R., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.145207 · Cited by 533 · see citing works
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes
Cox, P. J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, A. J., Stubbs, B., West, J., McLure, S. W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.010 · Cited by 530 · see citing works
Epigenetic control of CD8+ T cell differentiation
Henning, A. N., Roychoudhuri, R., & Restifo, N. P. (2018) · Nature reviews. Immunology · doi:10.1038/nri.2017.146 · Cited by 501 · see citing works
Man, K., Gabriel, S. S., Liao, Y., Gloury, R., Preston, S., Henstridge, D. C., Pellegrini, M., Zehn, D., Berberich‐Siebelt, F., Febbraio, M. A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.021 · Cited by 489 · see citing works
Metabolic and epigenetic regulation of T-cell exhaustion
Franco, F., Jaccard, A., Romero, P. J., Yu, Y.-R., & Ho, P. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00280-9 · Cited by 457 · see citing works
CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis
Stagg, J., Divisekera, U., Duret, H., Sparwasser, T. D., Teng, M. W. L., Darcy, P. K., & Smyth, M. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4246 · Cited by 401 · see citing works
Cham, C. M., Driessens, G., O'Keefe, J. P., & Gajewski, T. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200838289 · Cited by 388 · see citing works
β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.004 · Cited by 370 · see citing works
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense
Horton, J. L., Davidson, M. T., Kurishima, C., Vega, R. B., Powers, J., Matsuura, T. R., Petucci, C. J., Lewandowski, E. D., Crawford, P. A., Muoio, D. M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124079 · Cited by 365 · see citing works
Self-citationMa, E. H., Verway, M. J., Johnson, R. M., Roy, D. G., Steadman, M., Hayes, S., Williams, K. S., Sheldon, R. D., Samborska, B., Kosinski, P. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.003 · Cited by 364 · see citing works
Self-citationMethionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
Roy, D. G., Chen, J., Mamane, V. H., Ma, E. H., Muhire, B. M., Sheldon, R. D., Shorstova, T., Koning, R., Johnson, R. M., Esaulova, E., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.006 · Cited by 347 · see citing works
Self-citationTranscriptional insights into the CD8+ T cell response to infection and memory T cell formation
Best, J., Blair, D., Knell, J., Yang, E., Mayya, V., Doedens, A. L., Dustin, M. L., & Goldrath, A. W. (2013) · Nature Immunology · doi:10.1038/ni.2536 · Cited by 334 · see citing works
Low glycaemic diets alter lipid metabolism to influence tumour growth
Lien, E. C., Westermark, A. M., Zhang, Y., Yuan, C., Li, Z., Lau, A. N., Sapp, K. M., Wolpin, B. M., & Heiden, M. G. V. (2021) · Nature · doi:10.1038/s41586-021-04049-2 · Cited by 311 · see citing works
A non-canonical tricarboxylic acid cycle underlies cellular identity
Arnold, P. K., Jackson, B. T., Paras, K. I., Brunner, J. S., Hart, M. L., Newsom, O. J., Alibeckoff, S. P., Endress, J., Drill, E., Sullivan, L. B., et al. (2022) · Nature · doi:10.1038/s41586-022-04475-w · Cited by 304 · see citing works
Metabolic Pathway Alterations that Support Cell ProliferationPreprint
Heiden, M. G. V., Lunt, S. Y., Dayton, T. L., Fiske, B. P., Israelsen, W. J., Mattaini, K. R., Vokes, N. I., Stephanopoulos, G. N., Cantley, L. C., Metallo, C. M., et al. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2012.76.010900 · Cited by 300 · see citing works
Metabolic and Signaling Roles of Ketone Bodies in Health and Disease
Puchalska, P., & Crawford, P. A. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111120-111518 · Cited by 290 · see citing works
Self-citationMetabolic adaptation of lymphocytes in immunity and disease
Chapman, N. M., & Chi, H.-B. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.012 · Cited by 263 · see citing works
Gormsen, L. C., Svart, M. V., Thomsen, H. H., Søndergaard, E., Vendelbo, M. H., Christensen, N. L., Tolbod, L. P., Harms, H. J., Nielsen, R. R., Wiggers, H., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005066 · Cited by 235 · see citing works
Divergent clonal differentiation trajectories of T cell exhaustion
Dániel, B., Yost, K. E., Hsiung, S., Sandor, K. D., Xia, Y., Qi, Y., Hiam-Galvez, K. J., Black, M., Raposo, C. J., Shi, Q., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01337-5 · Cited by 226 · see citing works
Barnes, C. E., English, D. M., & Cowley, S. M. (2019) · Essays in Biochemistry · doi:10.1042/ebc20180061 · Cited by 225 · see citing works
Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development
Zhang, H., Tang, K., Ma, J., Zhou, L., Liu, J., Zeng, L., Zhu, L., Xu, P., Chen, J., Wei, K., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0440-0 · Cited by 205 · see citing works
Epigenetic Remodeling of the IL-2 and IFN -γ Loci in Memory CD8 T Cells Is Influenced by CD4 T Cells
Northrop, J. K., Thomas, R. M., Wells, A. D., & Shen, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1062 · Cited by 203 · see citing works
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue
Goldberg, E. L., Shchukina, I., Asher, J. L., Sidorov, S., Artyomov, M. N., & Dixit, V. D. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0160-6 · Cited by 162 · see citing works
Carbon source availability drives nutrient utilization in CD8+ T cells
Kaymak, I., Luda, K. M., Duimstra, L. R., Ma, E. H., Longo, J., Dahabieh, M. S., Faubert, B., Oswald, B. M., Watson, M. J., Kitchen-Goosen, S. M., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.07.012 · Cited by 160 · see citing works
Self-citationImpaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05128-8 · Cited by 146 · see citing works
Ketogenic diet activates protective γδ T cell responses against influenza virus infection
Goldberg, E. L., Molony, R. D., Kudo, E., Sidorov, S., Kong, Y., Dixit, V. D., & Iwasaki, A. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav2026 · Cited by 143 · see citing works
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy
Geltink, R. I. K., Edwards-Hicks, J., Apostolova, P., O’Sullivan, D., Sanin, D. E., Patterson, A. E., Puleston, D. J., Ligthart, N. A. M., Buescher, J. M., Grzes, K. M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0256-z · Cited by 141 · see citing works
Hepatocyte-Macrophage Acetoacetate Shuttle Protects Against Tissue Fibrosis
Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J., & Crawford, P. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.015 · Cited by 138 · see citing works
Self-citationLercher, A., Bhattacharya, A., Popa, A., Caldera, M., Schlapansky, M. F., Baazim, H., Agerer, B., Gürtl, B., Kosack, L., Májek, P., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.014 · Cited by 120 · see citing works
Chen, R., Bélanger, S., Frederick, M. A., Li, B., Johnston, R. J., Xiao, N., Liu, Y., Sharma, S., Peters, B., Rao, A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.002 · Cited by 117 · see citing works
Wei, R., Zhou, Y., Li, C., Rychahou, P. G., Zhang, S., Titlow, W. B., Bauman, G., Wu, Y., Liu, J., Wang, C., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2778 · Cited by 112 · see citing works
Gray, S. M., Kaech, S. M., & Staron, M. M. (2014) · Immunological Reviews · doi:10.1111/imr.12205 · Cited by 100 · see citing works
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming
Hirschberger, S., Strauß, G., Effinger, D., Marstaller, X., Ferstl, A., Müller, M. B., Wu, T., Hübner, M., Rahmel, T., Mascolo, H., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114323 · Cited by 98 · see citing works
Dynamic Regulation of IFN-γ Signaling in Antigen-Specific CD8+ T Cells Responding to Infection
Haring, J. S., Corbin, G. A., & Harty, J. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6791 · Cited by 97 · see citing works
Metabolic Adaptations to Infections at the Organismal Level
Troha, K., & Ayres, J. S. (2020) · Trends in Immunology · doi:10.1016/j.it.2019.12.001 · Cited by 97 · see citing works
CD8+ T cells induce cachexia during chronic viral infection
Baazim, H., Schweiger, M., Moschinger, M., Xu, H. C., Scherer, T., Popa, A., Gallage, S., Ali, A., Khamina, K., Kosack, L., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0397-y · Cited by 89 · see citing works
Immunometabolism of infections
Ayres, J. S. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0266-9 · Cited by 80 · see citing works
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression
Gouirand, V., Gicquel, T., Lien, E. C., Jaune, E., Costa, Q. D., Finetti, P., Metay, E., Duluc, C., Mayers, J. R., Audebert, S., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021110466 · Cited by 75 · see citing works
Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation
Cotter, D. G., Schugar, R. C., Wentz, A. E., d’Avignon, D. A., & Crawford, P. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00547.2012 · Cited by 70 · see citing works
Self-citationMMMDB: Mouse Multiple Tissue Metabolome Database
Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., & Soga, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1170 · Cited by 67 · see citing works
Ketone bodies as epigenetic modifiers
Ruan, H., & Crawford, P. A. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000475 · Cited by 66 · see citing works
Self-citationPopulation Dynamics of Naive and Memory CD8 T Cell Responses after Antigen Stimulations In Vivo
Martin, M. D., Condotta, S. A., Harty, J. T., & Badovinac, V. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101579 · Cited by 55 · see citing works
The Immunological Proteome Resource
Brenes, A. J., Hukelmann, J. L., Spinelli, L., Howden, A. J. M., Marchingo, J. M., Sinclair, L. V., Rollings, C. M., James, O. J., Phair, I. R., Matthews, S. P., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01483-4 · Cited by 52 · see citing works
Sheldon, R. D., Ma, E. H., DeCamp, L. M., Williams, K. S., & Jones, R. G. (2021) · Nature Protocols · doi:10.1038/s41596-021-00586-2 · Cited by 43 · see citing works
Self-citationEnemy or ally? Fasting as an essential regulator of immune responses
Wilhelm, C., Surendar, J., & Karagiannis, F. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.03.007 · Cited by 40 · see citing works
Ketone Bodies Improve Human CD8+ Cytotoxic T-Cell Immune Response During COVID-19 Infection
Hirschberger, S., Gellert, L. M., Effinger, D., Muenchhoff, M., Herrmann, M., Briegel, J., Zwißler, B., & Kreth, S. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.923502 · Cited by 28 · see citing works
Kadir, A. A., Stubbs, B. J., Chong, C., Lee, H., Cole, M. A., Carr, C. A., Hauton, D., McCullagh, J., Evans, R. D., & Clarke, K. (2023) · The Journal of Physiology · doi:10.1113/jp284270 · Cited by 27 · see citing works
A physical basis for quantitative ChIP-sequencing
Dickson, B. M., Tiedemann, R. L., Chomiak, A. A., Cornett, E. M., Vaughan, R. M., & Rothbart, S. B. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015353 · Cited by 18 · see citing works
Self-citationDemiröz, D., Platanitis, E., Bryant, M., Fischer, P., Prchal‐Murphy, M., Lercher, A., Lassnig, C., Baccarini, M., Müller, M. M., Bergthaler, A., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009697 · Cited by 17 · see citing works
Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate
MacIver, N. J., & Rathmell, J. C. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.06.002 · Cited by 14 · see citing works
Dickson, B. M., Kupai, A., Vaughan, R. M., & Rothbart, S. B. (2023) · Scientific Reports · doi:10.1038/s41598-023-34430-2 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
1 of the 82 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [80]80. Dickson, B.M. ∙ Kupai, A. ∙ Vaughan, R.M. ... Theoretical and practical refinements of sans spike-in quantitative ChIP-seq with application to p300/CBP inhibition Preprint at bioRxiv 2022 Crossref Google Scholar
Cited by
Sorted by citations
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works
Ping, Y., Shan, J., Qin, H., Li, F., Qu, J., Guo, R., Han, D. H., Wei, J., Liu, Y., Liu, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.003 · Cited by 142 · see citing works
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Bai, Z., Feng, B., McClory, S., de Oliveira, B. C., Diorio, C. J., Grégoire, C., Tao, B., Yang, L., Zhao, Z., Peng, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07762-w · Cited by 128 · see citing works
Metabolic Messengers: ketone bodies
Nelson, A. B., Queathem, E. D., Puchalska, P., & Crawford, P. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00935-3 · Cited by 115 · see citing works
Self-citationNutrients: Signal 4 in T cell immunity
Raynor, J. L., & Chi, H. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20221839 · Cited by 94 · see citing works
Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
Qiu, Y., Su, Y., Xie, E., Cheng, H., Du, J., Xu, Y., Pan, X., Wang, Z., Chen, D. G., Hong, Z., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.11.003 · Cited by 93 · see citing works
Cai, H., Chen, X., Liu, Y., Chen, Y.-B., Zhong, G., Chen, X., Rong, S., Zeng, H., Zhang, L., Li, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58563-2 · Cited by 102 · see citing works
A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism
Thind, M. K., Uhlig, H. H., Glogauer, M., Palaniyar, N., Bourdon, C., Gwela, A., Lancioni, C., Berkley, J. A., Bandsma, R., & Farooqui, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1334205 · Cited by 76 · see citing works
Murphy, S., Rahmy, S., Gan, D., Liu, G., Zhu, Y., Manyak, M., Duong, L., He, J., Schofield, J. H., Schafer, Z. T., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2742 · Cited by 73 · see citing works
Macrophages and T cells in metabolic disorder-associated cancers
Taranto, D., Kloosterman, D., & Akkari, L. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 67 · see citing works
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation
Liu, W., You, D., Lin, J., Zou, H., Zhang, L., Luo, S., Yuan, Y., Wang, Z., Qi, J., Wang, W., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.08.005 · Cited by 61 · see citing works
13 C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells
Ma, E. H., Dahabieh, M. S., DeCamp, L. M., Kaymak, I., Kitchen-Goosen, S. M., Oswald, B. M., Longo, J., Roy, D. G., Verway, M. J., Johnson, R. M., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj1431 · Cited by 53 · see citing works
Self-citationSpatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective
Xiao, Y., Li, Y., & Zhao, H. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02113-9 · Cited by 59 · see citing works
Zhuang, H., Ren, X., Zhang, Y., Li, H., & Zhou, P. (2024) · Aging Cell · doi:10.1111/acel.14294 · Cited by 52 · see citing works
ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses
Kaymak, I., Watson, M. J., Oswald, B. M., Ma, S., Johnson, B. K., DeCamp, L. M., Mabvakure, B. M., Luda, K. M., Ma, E. H., Lau, K. H., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20231820 · Cited by 53 · see citing works
Self-citationMissiego-Beltrán, J., & Beltrán-Velasco, A. I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810041 · Cited by 55 · see citing works
Mills, T., Kain, B. N., Burchill, M. A., Danis, E. P., Lucas, E. D., Culp‐Hill, R., Cowan, C. M., Schleicher, W. E., Patel, S. B., Tran, B. T., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.09.010 · Cited by 51 · see citing works
Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer
Viel, S., Vivier, É., Walzer, T., & Marçais, A. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01098-w · Cited by 51 · see citing works
A two-way relationship between histone acetylation and metabolism
Charidemou, E., & Kirmizis, A. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.10.005 · Cited by 47 · see citing works
The epigenetic hallmarks of immune cells in cancer
Yu, J. H., Xiao, C., Fan, T. T., Deng, Z., Wang, D., Cai, W., Li, J., Liao, T., Li, C., & He, J. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02255-4 · Cited by 49 · see citing works
Cancer cachexia: molecular basis and therapeutic advances
Tan, Y., Xue, R., Pan, Y., he, Z., Hu, X., Li, Y., Li, K., Zhang, X., Bian, X.-W., & Wang, B. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02331-7 · Cited by 48 · see citing works
Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy
Zhang, H., Fan, J., Kong, D., Sun, Y., Zhang, Q., Xiang, R., Lu, S., Yang, W., Feng, L., & Zhang, H. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02460-1 · Cited by 48 · see citing works
Metabolites as agents and targets for cancer immunotherapy
Trefny, M. P., Kroemer, G., Zitvogel, L., & Kobold, S. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01227-z · Cited by 48 · see citing works
Dietary and metabolic effects on intestinal stem cells in health and disease
Shay, J. E. S., & Yilmaz, Ö. H. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00980-7 · Cited by 42 · see citing works
The cyclic metabolic switching theory of intermittent fasting
Mattson, M. P. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01254-5 · Cited by 45 · see citing works
Liang, Y. J., Wang, L., Ma, P., Ju, D., Zhao, M., & Shi, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1308264 · Cited by 42 · see citing works
Metabolic rewiring and communication in cancer immunity
Chapman, N. M., & Chi, H. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.02.001 · Cited by 43 · see citing works
Qin, S., Xie, B., Wang, Q., Yang, R., Sun, J., Hu, C., Liu, S., Tao, Y., & Xiao, D. (2024) · MedComm · doi:10.1002/mco2.551 · Cited by 40 · see citing works
Feng, J., Xiao, X., Xia, X., Min, J., Tang, W., Shi, X., Xu, K., Zhou, G., Li, K., Shen, P., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.07.006 · Cited by 38 · see citing works
Protein post-translational modifications and tumor immunity: A pan-cancer perspective
Zhang, H., Yan, Q., Jiang, S., Hu, D., Lu, P., Li, S., Sandai, D. A., Zhang, H., Zhang, W., & Zhu, C. (2025) · Physics of Life Reviews · doi:10.1016/j.plrev.2025.10.001 · Cited by 34 · see citing works
Oswald, B. M., DeCamp, L. M., Longo, J., Dahabieh, M. S., Bunda, N., Johnson, B. K., Watson, M. J., Ma, S., Preston, S. E. J., Sheldon, R. D., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01415-6 · Cited by 32 · see citing works
Self-citationOvercoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade
Stefan, V. E., Weber, D. D., Lang, R., & Kofler, B. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03867-3 · Cited by 30 · see citing works
The flux of energy in critical illness and the obesity paradox
Jaitovich, A., & Hall, J. B. (2025) · Physiological Reviews · doi:10.1152/physrev.00029.2024 · Cited by 33 · see citing works
Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions
Cote, A. L., Munger, C. J., & Ringel, A. E. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115234 · Cited by 28 · see citing works
Long COVID: Long-Term Impact of SARS-CoV2
Makhluf, H. A., Madany, H., & Kim, K. (2024) · Diagnostics · doi:10.3390/diagnostics14070711 · Cited by 28 · see citing works
Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation
Queathem, E. D., Moazzami, Z., Stagg, D. B., Nelson, A. B., Fulghum, K., Hayir, A., Seay, A., Gillingham, J. R., d’Avignon, D. A., Han, X., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads0535 · Cited by 30 · see citing works
Self-citationGlucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
Longo, J., DeCamp, L. M., Oswald, B. M., Teis, R., Reyes-Oliveras, A., Dahabieh, M. S., Ellis, A. E., Vincent, M. P., Damico, H. N., Gallik, K. L., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.006 · Cited by 28 · see citing works
Self-citationThe therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle
Soni, S., Dakhili, S. A. T., Ussher, J. R., & Dyck, J. R. B. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00501.2023 · Cited by 27 · see citing works
Metabolic plasticity of T cell fate decision
Pan, X., Wang, J., Zhang, L., Li, G., & Huang, B. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002989 · Cited by 24 · see citing works
A diverse proteome is present and enzymatically active in metabolite extracts
House, R. J., Soper-Hopper, M. T., Vincent, M. P., Ellis, A. E., Capan, C. D., Madaj, Z., Wolfrum, E., Isaguirre, C. N., Castello, C. D., Johnson, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50128-z · Cited by 25 · see citing works
Self-citationPivotal role of exogenous pyruvate in human natural killer cell metabolism
Coquillat, N. K., Picq, L., Hamond, A., Megy, P., Benezech, S., Drouillard, A., Lager-Lachaud, N., Cahoreau, E., Moreau, M., Fallone, L., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01188-4 · Cited by 24 · see citing works
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion
Dahabieh, M. S., DeCamp, L. M., Oswald, B. M., Kitchen-Goosen, S. M., Fu, Z. F., Vos, M., Compton, S. E., Longo, J., Foy, N. M., Williams, K. S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02185-9 · Cited by 24 · see citing works
Self-citationWang, J., Wang, J., Yu, Z., Wen, H., Zhao, C.-S., Zhong, J., Xiao, C., Li, Y., Xu, J., Wang, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202411813 · Cited by 23 · see citing works
Liu, K., Li, Y., Shen, M., Xu, W., Wu, S., Yang, X., Zhang, B., & Lin, N. (2025) · Biomolecules · doi:10.3390/biom15010071 · Cited by 23 · see citing works
Ketone bodies as chemical signals for the immune system
Gonzatti, M. B., & Goldberg, E. L. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00478.2023 · Cited by 21 · see citing works
Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy
Yao, Z., Zeng, Y., Liu, C., Jin, H., Wang, H., Zhang, Y., Ding, C., Chen, G., & Wu, D. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03195-5 · Cited by 23 · see citing works
Nutrient allocation fuels T cell-mediated immunity
Longo, J., Watson, M. J., Williams, K. S., Sheldon, R. D., & Jones, R. G. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.008 · Cited by 19 · see citing works
Self-citationTang, K., Huang, C., Huang, Z., Wang, Z., & Tan, N. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02638-3 · Cited by 19 · see citing works
Emerging Pathophysiological Roles of Ketone Bodies
Tsuruta, H., Yamahara, K., Yasuda‒Yamahara, M., & Kume, S. (2024) · Physiology · doi:10.1152/physiol.00031.2023 · Cited by 19 · see citing works
β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer
Liu, S., Guruprasad, P., Ramasubramanian, R., Madhu, B., Paruzzo, L., Han, K., Kelly, A. R., Shestov, A. A., Xu, H. N., Carturan, A., et al. (2026) · Cell · doi:10.1016/j.cell.2026.02.004 · Cited by 19 · see citing works
The diverse interaction of metabolism, immune response, and viral pathogens
Kanno, T., Miyako, K., & Endo, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1619926 · Cited by 17 · see citing works
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment
Plata-Gómez, A. B., & Ho, P. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241102 · Cited by 16 · see citing works
Kaluba, F. C., Rogers, T. J., Jeong, Y., House, R. J., Waldhart, A. N., Sokol, K. H., Daniels, S. R., Lee, C. J., Longo, J., Johnson, A., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01366-y · Cited by 15 · see citing works
Self-citationThe uncharted territory of host-pathogen interaction in tuberculosis
Ghoshal, A., Verma, A., Bhaskar, A., & Dwivedi, V. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1339467 · Cited by 15 · see citing works
Li, Z., Guo, Y., Xiong, J., Bai, L., Tang, H., Wang, B., Guo, B., Yi, Q., Li, G., Gong, M., et al. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.11.004 · Cited by 14 · see citing works
β-Hydroxybutyrate dehydrogenase 1: A promising therapeutic target for diverse diseases
Ma, X., Wang, Z., Gao, H., Zhu, D., Wu, M., Zhao, L., & Xiao, W. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117070 · Cited by 12 · see citing works
Reprogramming T-cell metabolism to enhance adoptive cell therapies
Kates, M., & Saibil, S. D. (2024) · International Immunology · doi:10.1093/intimm/dxae007 · Cited by 12 · see citing works
Patterson, A. R., Needle, G. A., Sugiura, A., Jennings, E. Q., Chi, C., Steiner, K. K., Fisher, E. L., Robertson, G. L., Bodnya, C., Markle, J., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adh0368 · Cited by 12 · see citing works
Self-citationKetogenic diet and cancer: multidimensional exploration and research
Wan, S., Zhou, X., Xie, F., Zhou, F., & Zhang, L. (2025) · Science China Life Sciences · doi:10.1007/s11427-023-2637-2 · Cited by 13 · see citing works
Zhao, B., Wan, J., Zhou, H., Yang, J., & Wan, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1669796 · Cited by 12 · see citing works
Krogstad, K. C., Fehn, J. F., Mamedova, L. K., Bernard, M. P., & Bradford, B. J. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-24974 · Cited by 11 · see citing works
Grundler, F., Mesnage, R., Cerrada, A., & de Toledo, F. W. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1195270 · Cited by 11 · see citing works
Nanovaccines: Antigen selection, stabilization, adjuvantation, formulation, and evaluation
Lu, L., Yang, M., Deng, D., Shi, X., Lovell, J. F., & Jin, H. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216806 · Cited by 10 · see citing works
Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy
Mi, C., Zhou, S., & Xue, J. (2025) · Aging and Disease · doi:10.14336/ad.2025.0061 · Cited by 9 · see citing works
Chen, X., Ge, J., Cai, X., Jin, L., Wei, H., Zhao, X., Yang, H., Jiang, W., Cheng, Z., Xue, C., et al. (2025) · Journal of Integrative Plant Biology · doi:10.1111/jipb.70027 · Cited by 9 · see citing works
Sulfur partitioning from cysteine controls T cell proliferation and effector function
Kelly, B., Cha, M., Gremelspacher, T., Martin, J. L., Andreis, M., Maloo, I., Carrizo, G., Gidley, M., Stanczak, M. A., Apostolova, P., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.012 · Cited by 9 · see citing works
Self-citationScaglione, M., Knight, M., Trihemasava, K., Rome, K., Archambault, A., Oh, J., Tanaka, E., Hall, E., Le, T. N. V., Lines, C. L., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.004 · Cited by 10 · see citing works
Nutritional modulation of antitumor immunity
Jeong, M., & Collins, N. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102422 · Cited by 8 · see citing works
Laroni, A., Carlini, F., Squillario, M., Casella, V., Capaia, M., Lusi, V., Bagnara, D., Colombo, M., Palmeri, S., Ivaldi, F., et al. (2025) · Genes and Immunity · doi:10.1038/s41435-025-00338-2 · Cited by 8 · see citing works
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies
Zhang, T., Gao, P., & Sun, L. (2025) · MedComm – Oncology · doi:10.1002/mog2.70045 · Cited by 9 · see citing works
16-h fasting optimizes cancer immunotherapy in mice and humans
Chen, S., Hu, T., Zhu, K., Liu, Y., Yang, Y., Li, X., He, J., Cui, W., Chi, Z., Yu, W., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.01.015 · Cited by 8 · see citing works
Control of T-cell immunity by fatty acid metabolism
Kim, J., Lee, Y., & Chung, Y. (2024) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2448160.080 · Cited by 7 · see citing works
Fu, H., Zhao, W., Jiang, L., & Shan, S. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s522458 · Cited by 7 · see citing works
Ketogenic Diet Reduces Age-Induced Chronic Neuroinflammation in Mice
Newman, J. C., Nomura, M., Murad, N. F., Madhavan, S. S., Mu, W., Eap, B., Garcia, T. Y., Aguirre, C. G., Verdin, E. M., Ellerby, L., et al. (2024) · doi:10.59368/agingbio.20240038 · Cited by 6 · see citing works
A ketogenic diet reduces age-induced chronic neuroinflammation in micePreprint
Nomura, M., Murad, N. F., Madhavan, S. S., Eap, B., Garcia, T. Y., Aguirre, C. G., Verdin, E. M., Ellerby, L., Furman, D., & Newman, J. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.01.569598 · Cited by 6 · see citing works
Altered immunometabolic response to fasting in humans living with obesity
Neudorf, H., Sandilands, R. E., Ursel, S., Shaba, H., Barg, D., Tsusaka, T., Moya-Garzón, M. D., Vaz, E. M., Schimweg, P., Goldberg, E. L., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112872 · Cited by 5 · see citing works
Cheng, S., Cheng, C., Zhou, J., Ji, Y. S., Liu, Y., Jiang, W., Liu, C., & Wang, H. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf258 · Cited by 5 · see citing works
Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response
Fernández‐Gallego, N., Anega, B., Luengo-Arias, S., Bizkarguenaga, M., Gil‐Redondo, R., Embade, N., Navarrete-Arias, L., Ramírez‐Huesca, M., Álvarez-Corrales, E., Dosil, S. G., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00250-2 · Cited by 5 · see citing works
NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustionPreprint
Dahabieh, M. S., DeCamp, L. M., Oswald, B. M., Kitchen-Goosen, S. M., Fu, Z. F., Vos, M., Compton, S. E., Longo, J., Williams, K. S., Ellis, A. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.23.600279 · Cited by 5 · see citing works
Self-citationAcetyl-CoA subcellular compartmentalization regulates T cell adaptation
Tiggeler, A., & Coffer, P. J. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.105000 · Cited by 4 · see citing works
Yang, Y., Tang, X., & Liu, Z. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251336275 · Cited by 5 · see citing works
A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression
Han, X., Wang, K., Ma, W., Zhu, S., Guan, J., Tian, X., Zhao, Z., & Jiang, L. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.04.013 · Cited by 3 · see citing works
The Ketone Bridge Between the Heart and the Bladder: How Fast Should We Go?
Faria‐Costa, G., Oliveira, J., Vilas-Boas, I., Campelo, I., Silva, E. A., Brás‐Silva, C., Silva, S. M., Antunes‐Lopes, T., & Charrua, A. (2024) · International Neurourology Journal · doi:10.5213/inj.2346250.125 · Cited by 3 · see citing works
Metabolic footprint and logic through the T cell life cycle
Fan, T., Shah, R., & Wang, R. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102487 · Cited by 3 · see citing works
Disease-associated programming of cell memory in glycogen storage disorder type 1aPreprint
Sprecher, U., D’Souza, J., Mishra, K., Muchtar, N., Shalev, O., Eliassaf, A., Morshina, A., Miliano, A. C., Mithieux, G., Rajas, F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.20.529109 · Cited by 3 · see citing works
Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stressPreprint
Scaglione, M., Knight, M., Trihemasava, K., Rome, K., Archambault, A., Oh, J., Tanaka, E., Hall, E., Le, T. N. V., Lines, C. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.632829 · Cited by 3 · see citing works
Islam, H. (2025) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001157 · Cited by 2 · see citing works
Obesity rewires CD8+ T cell iron metabolism in adipose tissue to fuel metabolic inflammation
Dai, J., Zeng, Z., Wang, L., Yuan, W., Rocha, K. C. E., Park, J., An, G., Wang, K., Song, J., Xiang, Q., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156438 · Cited by 2 · see citing works
Qi, M., Song, T., Deng, Y., Li, N., Wang, N., Zha, A., Ye, Q., Wang, C., Shao, Y., Zhu, Y., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.11.039 · Cited by 2 · see citing works
Targeting immunometabolism in cancer through pharmacological and lifestyle interventions
Tan, R. J. Y., Liu, Y., Chen, W., Liang, Y., & Ling, G. S. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003617 · Cited by 2 · see citing works
Metabolism of tumor infiltrating T cells
Ertl, H. C. J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1711328 · Cited by 2 · see citing works
The value of targeting ketone body metabolism in inflammatory and autoimmune diseases
Gong, Y., Wei, Y., (18461), Y. L., & Du, T. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07884-x · Cited by 2 · see citing works
Wang, W., Wu, Z., Li, Y., & Wang, D. (2026) · Aquatic Toxicology · doi:10.1016/j.aquatox.2026.107935 · Cited by 2 · see citing works
Song, S., Zhang, X., Zheng, H., Liao, Y., Tang, P., Liu, Y., Tang, A., Ran, P., Sun, X., & Yang, P. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70014 · Cited by 2 · see citing works
Chen, B., Yuan, S., & Wang, H. (2025) · Oncology Letters · doi:10.3892/ol.2025.15048 · Cited by 2 · see citing works
An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cellsPreprint
Kaluba, F. C., Rogers, T. J., Jeong, Y., Waldhart, A. N., Sokol, K. H., Lee, C. J., Daniels, S. R., Longo, J., Johnson, A., Sheldon, R. D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.31.621317 · Cited by 2 · see citing works
Self-citationHu, J., Wang, X., Li, H., Zeng, S., Yang, B., Li, F., & Tang, Y. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c00449 · Cited by 1 · see citing works
Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method
Adámez-Rodríguez, S., Queathem, E. D., Hayir, A., Marina, M. L., Castro‐Puyana, M., & Puchalska, P. (2025) · Talanta · doi:10.1016/j.talanta.2025.128919 · Cited by 1 · see citing works
Self-citationBeyond Energy Fuel: Ketone Bodies as Multifaceted Modulators of T Cell and Anti‐Tumour Immunity
Gu, Z., Zhang, M.-H., & Xia, S. (2025) · Scandinavian Journal of Immunology · doi:10.1111/sji.70067 · Cited by 1 · see citing works
Molecular Targets for Cancer Immunotherapy: Focusing on (Immune and Tumor) Cell-Derived Metabolites
Quintans, R. D. T., de Freitas, Â. A., de Souza, M. M., Dias-Lopes, G., & Silva, R. C. M. C. (2026) · Applied Sciences · doi:10.3390/app16052461 · Cited by 1 · see citing works
- Authors
- Luda, K. M., Longo, J., Kitchen-Goosen, S. M., Duimstra, L. R., Ma, E. H., Watson, M. J., Oswald, B. M., Fu, Z., Madaj, Z., Kupai, A., Dickson, B. M., DeCamp, L. M., Dahabieh, M. S., Compton, S. E., Teis, R., Kaymak, I., Lau, K. H., Kelly, D. P., Puchalska, P., Williams, K. S., Krawczyk, C. M., Lévesque, D., Boisvert, F.-M., Sheldon, R. D., Rothbart, S. B., Crawford, P. A., & Jones, R. G.
- Affiliations
- University of Copenhagen (DK)
- Van Andel Institute (US)
- University of Pennsylvania (US)
- University of Minnesota (US)
- Université de Sherbrooke (CA)
- Corresponding author
- Jones, Russell G.
- ORCID
- Luda, Katarzyna M.
- Longo, Joseph
- Kitchen-Goosen, Susan M.
- Duimstra, Lauren R.
- Ma, Eric H.
- Watson, McLane J.
- Oswald, Brandon M.
- Fu, Zhen
- Madaj, Zachary
- Kupai, Ariana
- Dickson, Bradley M.
- DeCamp, Lisa M.
- Dahabieh, Michael S.
- Compton, Shelby E.
- Teis, Robert
- Kaymak, Irem
- Lau, Kin H.
- Kelly, Daniel P.
- Puchalska, Patrycja
- Williams, Kelsey S.
- Krawczyk, Connie M.
- Lévesque, Dominique
- Boisvert, François-Michel
- Sheldon, Ryan D.
- Rothbart, Scott B.
- Crawford, Peter A.
- Jones, Russell G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2023-09
- Volume
- 56
- Issue
- 9
- Pages
- 2021-2035.e8
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC10528215
- OpenAlex
- W4385351665
- Cited by
- 140
- References
- 82
- Citations by year
- 2026: 44 · 2025: 52 · 2024: 38 · 2023: 6
- FWCI
- 15.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AG069781)
- Canadian Institutes of Health Research (281824, 181903_1)
- Fonds de Recherche du Québec - Santé (281824)
- National Institute on Aging (AG069781, R01AG069781)
- National Heart, Lung, and Blood Institute (R01HL128349, R01HL151345)
- National Cancer Institute (T32CA251066)
- National Institute of General Medical Sciences (R35GM124736)
- National Institute of Allergy and Infectious Diseases (R21AI153997, R01AI165722)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK091538, R01DK091538)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- ketolysis, ketone bodies, beta-hydroxybutyrate, acetoacetate, CD8+ T cells, T cell metabolism, histone acetylation, acetyl-CoA, TCA cycle, cytokine production, cytotoxicity, bacterial infection, antitumor immunity, epigenetic regulation, glucose metabolism
- MeSH terms
- Acetylation, Animals, Histones, Ketone Bodies, CD8-Positive T-Lymphocytes, 3-Hydroxybutyric Acid, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
