The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting
Open accessAbstract
Lifelong protection against severe influenza: The first influenza attack that a child suffers can affect the way that their lifelong immunity to the virus builds up. A wide range of influenza A virus subtypes infect humans. Subtype H5 belongs to HA group 1 (which also includes H1 and H2 subtypes), and subtype H7 belongs to HA group 2 (which also includes the H3 subtype). Gostic et al. found that birth-year cohorts that experienced first infections with seasonal H3 subtype viruses were less susceptible to the potentially fatal avian influenza H7N9 virus (see the Perspective by Viboud and Epstein). Conversely, older individuals who were exposed to H1 or H2 subtype viruses as youngsters were less susceptible to avian H5N1-bearing viruses. A mathematical model of the protective effect of this imprinting could potentially prove useful to predict the age distribution and severity of future pandemics. Science , this issue p. 722 ; see also p. 706
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Cited by
Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.015 · Cited by 3,595
Adaptive immunity to SARS-CoV-2 and COVID-19
Sette, A., & Crotty, S. (2021) · Cell · doi:10.1016/j.cell.2021.01.007 · Cited by 1,860
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“In a notable example of this, Gostic et al. (2016) analyzed epidemiologic data from six countries over nearly 100 years and showed that an abrupt worldwide change in human infections of avian influenza A/H5N1 and A/H7N9 around birth year 1968 could be attributed solely to the widespread use of a…”
BackgroundThe global H5N1 influenza panzootic in mammals
Peacock, T. P., Moncla, L., Dudas, G., VanInsberghe, D., Sukhova, K., Lloyd-Smith, J. O., Worobey, M., Lowen, A. C., & Nelson, M. I. (2025) · Nature · doi:10.1038/s41586-024-08054-z · Cited by 445
Self-citation
Metadata
- Authors
- Gostic, K. M., Ambrose, M., Worobey, M., & Lloyd-Smith, J. O.
- Venue
- Science
- Published
- 2016-11-11
- Volume
- 354
- Issue
- 6313
- Pages
- 722-726
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2557207823
- Cited by
- 462
- References
- 60
- FWCI
- 35.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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