Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
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and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly than target cells convert to pharmacologically active drug. This study provides evidence linking vaginal bacteria to microbicide efficacy through tenofovir depletion via bacterial metabolism.
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G. vaginalis and other anaerobic bacteria metabolize tenofovir and deplete it more rapidly than target cells convert it to active state.
“G. vaginalis and other anaerobic bacteria were found to metabolize tenofovir, and therefore deplete it, more rapidly than target cells converted it to its pharmacologically active state (Klatt et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Klatt et al., 2017
Tenofovir reduced HIV incidence by 61% in Lactobacillus-dominant women but only 18% in CST-IV women.
“Interestingly, the researchers identified that tenofovir reduced HIV incidence by 61% (P = 0.013) in Lactobacillus (sensu lato) dominant women but only 18% (P = 0.644) in CST-IV women (Klatt et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Klatt et al., 2017
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- Authors
- Klatt, N. R., Cheu, R., Birse, K., Zevin, A. S., Perner, M., Noël-Romas, L., Grobler, A., Westmacott, G., Xie, I. Y., Butler, J., Mansoor, L., McKinnon, L. R., Passmore, J.-A. S., Abdool Karim, Q., Abdool Karim, S. S., & Burgener, A. D.
- Affiliations
- University of Washington (US)
- Public Health Agency of Canada (CA)
- National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
- Centre for the AIDS Programme of Research in South Africa (ZA)
- National Health Laboratory Service (ZA)
- Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
- Karolinska University Hospital (SE)
- Corresponding author
- Klatt, Nichole R.
- Cheu, Ryan
- Birse, Kenzie
- Zevin, Alexander S.
- Perner, Michelle
- Burgener, Adam D.
- ORCID
- Venue
- Science
- Published
- 2017-06-02
- Volume
- 356
- Issue
- 6341
- Pages
- 938-945
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2619565046
- Cited by
- 428
- References
- 44
- Citations by year
- 2026: 29 · 2025: 21 · 2024: 27 · 2023: 42 · 2022: 38 · 2021: 49 · 2020: 64 · 2019: 59 · 2018: 74 · 2017: 25
- FWCI
- 47.14
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of KwaZulu-Natal) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (award299152, TMI-138658)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- tenofovir, HIV prevention, vaginal microbicides, vaginal bacteria, anaerobic bacteria, drug metabolism, vaginal microbiota, African women
- MeSH terms
- Tenofovir, Adult, Antiviral Agents, Bacteria, Female, Humans, Lactobacillus, RNA, Ribosomal, 16S, South Africa, Mass Spectrometry, Vagina, HIV Infections, Gardnerella, Proteome, Biodiversity, Microbiota
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