Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats.
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Abstract
Dendrites are more active than expected: Dendrites occupy more than 90% of neuronal tissue. However, it has not been possible to measure distal dendritic membrane potential and spiking in vivo over a long period of time. Moore et al. developed a technique to record the subthreshold membrane potential and spikes from neocortical distal dendrites in freely behaving animals. These recordings were very stable, providing data from a single dendrite for up to 4 days. Unexpectedly, distal dendrites generated action potentials whose firing rate was nearly five times greater than at the cell body. Science , this issue p. eaaj1497
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The human brain might even have more than 100 times higher computational capacity than previously thought, based on the discovery that dendrites may generate nearly 10 times as many electrochemical spikes as do neuron soma, and are hybrids that process both analog and digital signals.
“The human brain might even have more than 100 times higher computational capacity than previously thought, based on the discovery that dendrites may generate nearly 10 times as many electrochemical spikes as do neuron soma, and are hybrids that process both analog and digital signals”
From Human Brain/Cloud Interface (2019) · cites this paper as Moore et al., 2017
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Cites
Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.
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Neuronal Dynamics of Predictive Coding
Mehta, M. R. (2001) · The Neuroscientist · doi:10.1177/107385840100700605 · Cited by 67 · see citing works
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Research works printed but not linked: 8
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Martins, N. R. B., Angelica, A., Chakravarthy, K., Svidinenko, Y., Boehm, F. J., Opris, I., Lebedev, M. A., Swan, M., Garan, S. A., Rosenfeld, J. V., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00112 · Cited by 91 · see citing works
Linking hippocampal multiplexed tuning, Hebbian plasticity and navigation
Moore, J. J., Cushman, J. D., Acharya, L., Popeney, B., & Mehta, M. R. (2021) · Nature · doi:10.1038/s41586-021-03989-z · Cited by 69 · see citing works
Self-citation
- Authors
- Moore, J. J., Ravassard, P. M., Ho, D., Acharya, L., Kees, A. L., Vuong, C., & Mehta, M. R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Moore, Jason J.
- Mehta, Mayank R.
- ORCID
- Venue
- Science
- Published
- 2017-03-24
- Volume
- 355
- Issue
- 6331
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2562989337
- Cited by
- 110
- References
- 4
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 10 · 2021: 17 · 2020: 13 · 2019: 19 · 2018: 10 · 2017: 6
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic action potentials, neocortex, freely moving rats, tetrode recordings, parietal cortex, neural coding, dendritic plasticity
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Cerebral Cortex, Dendrites, Electrodes, Implanted, Male, Membrane Potentials, Neuroglia, Sleep, Pyramidal Cells, Rats, Inbred LEC, Rats
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