The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)
Open accessAbstract
Making an unbiased library: Sequencing the genome of single cells gives insight into issues such as cell-to-cell heterogeneity and genome instability. Key to single-cell sequencing techniques are whole-genome amplification (WGA) methods that provide sufficient DNA for next-generation sequencing. Current WGA methods have been hampered by low accuracy and spatial resolution of gene copy numbers and by low amplification fidelity. Chen et al. report an improved single-cell WGA method, Linear Amplification via Transposon Insertion (LIANTI). The DNA is randomly fragmented by Tn5 transposition of a transposon that includes a T7 promoter, which allows linear amplification. The authors used the method to determine the spectrum of single-nucleotide variations in a single human cell after ultraviolet radiation. Science , this issue p. 189
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Metadata
- Authors
- Chen, C., Xing, D., Tan, L., Li, H., Zhou, G., Huang, L., & Xie, X. S.
- Venue
- Science
- Published
- 2017-04-14
- Volume
- 356
- Issue
- 6334
- Pages
- 189-194
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2605512081
- Cited by
- 391
- References
- 63
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- green
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