The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Epigenetic plasticity and the hallmarks of cancer
Open accessAbstract
Cancer epigenetics in the driver's seat: Recent cancer genome projects unexpectedly highlighted the role of epigenetic alterations in cancer development. About half of human cancers were found to harbor mutations in chromatin proteins. In a Review, Flavahan et al. propose that chromatin and epigenetic aberrations have the potential to confer on cells the full range of oncogenic properties represented in the classic “hallmarks” depiction of cancer. They suggest that genetic, environmental, and metabolic factors can make chromatin aberrantly permissive or restrictive. Permissive chromatin creates a state of “epigenetic plasticity,” which can activate oncogene expression or cell fate changes that drive cancer development. Science , this issue p. eaal2380
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“Alterations in chromatin state have been associated with many diseases including several cancers1.”
From Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens (2021) · cites this paper as [1]
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“It was demonstrated that ipilimumab induces the expression of EZH2, a key epigenetic enzyme that plays an important role in cellular plasticity (115-118).”
From The Next Decade of Immune Checkpoint Therapy (2021) · cites this paper as [115]
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Cites
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Cited by
Sorted by citations
Hallmarks of Cancer: New Dimensions
Hanahan, D. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1059 · Cited by 9,887
Molecular principles of metastasis: a hallmark of cancer revisited
Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,536
Schirrmacher, V. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4661 · Cited by 1,342
The chromatin accessibility landscape of primary human cancers
Corces, M. R., Granja, J. M., Shams, S., Louie, B. H., Seoane, J. A., Zhou, W., Silva, T. C., Groeneveld, C., Wong, C. K., Cho, S. W., et al. (2018) · Science · doi:10.1126/science.aav1898 · Cited by 1,230
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance
Marusyk, A., Janiszewska, M., & Polyak, K. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.007 · Cited by 1,009
Metadata
- Authors
- Flavahan, W. A., Gaskell, E., & Bernstein, B. E.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Bernstein, Bradley E.
- Venue
- Science
- Published
- 2017-07-21
- Volume
- 357
- Issue
- 6348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5940341
- OpenAlex
- W2737272162
- Cited by
- 1,340
- References
- 117
- Citations by year
- 2026: 142 · 2025: 127 · 2024: 156 · 2023: 168 · 2022: 160 · 2021: 188 · 2020: 174 · 2019: 128 · 2018: 80 · 2017: 15
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (award310374, DP1CA216873)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- epigenetic plasticity, cancer hallmarks, chromatin, epigenetic landscape, tumor suppressor, oncogene activation, cell fate transitions, tumor evolution, tumor initiation, driver mutations, cell differentiation
- MeSH terms
- Chromatin, Humans, Neoplasms, Oncogenes, DNA Methylation, Epigenesis, Genetic, Carcinogenesis
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