Epigenetic plasticity and the hallmarks of cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

Rao, S. S. P., Huntley, M. H., Durand, N. C., Stamenova, E. K., Bochkov, I. D., Robinson, J. T., Sanborn, A. L., Machol, I., Omer, A. D., Lander, E. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.021 · Cited by 9,212

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857

IDH1 and IDH2 Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

The Epigenomics of Cancer

Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

Hallmarks of Cancer: New Dimensions

Hanahan, D. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1059 · Cited by 9,887

Molecular principles of metastasis: a hallmark of cancer revisited

Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,536

From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review)

Schirrmacher, V. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4661 · Cited by 1,342

The chromatin accessibility landscape of primary human cancers

Corces, M. R., Granja, J. M., Shams, S., Louie, B. H., Seoane, J. A., Zhou, W., Silva, T. C., Groeneveld, C., Wong, C. K., Cho, S. W., et al. (2018) · Science · doi:10.1126/science.aav1898 · Cited by 1,230

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

Marusyk, A., Janiszewska, M., & Polyak, K. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.007 · Cited by 1,009

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Vitale, I., Shema, E., Loi, S., & Galluzzi, L. (2021) · Nature Medicine · doi:10.1038/s41591-021-01233-9 · Cited by 848

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Lee, S., Rauch, J., & Kölch, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031102 · Cited by 823

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

Li, T., Hu, P.-S., Zuo, Z., Lin, J., Li, X., Wu, Q.-N., Chen, Z., Zeng, Z.-L., Wang, F., Zheng, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1038-7 · Cited by 797

The Next Decade of Immune Checkpoint Therapy

Sharma, P., Siddiqui, B. A., Anandhan, S., Yadav, S. S., Subudhi, S. K., Gao, J., Goswami, S., & Allison, J. P. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1680 · Cited by 750

Genetics and biology of prostate cancerPreprint

Wang, G., Zhao, D., Spring, D. J., & DePinho, R. A. (2018) · Genes & Development · doi:10.1101/gad.315739.118 · Cited by 814

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., Li, Y., Chen, H., Yang, H., Hsu, P.-H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.052 · Cited by 693

Non-genetic mechanisms of therapeutic resistance in cancer

Marine, J., Dawson, S., & Dawson, M. A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00302-4 · Cited by 698

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sanderson, S. M., Gao, X., Dai, Z., & Locasale, J. W. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0187-8 · Cited by 601

Overcoming cancer therapeutic bottleneck by drug repurposing

Zhang, Z., Zhou, L., Xie, N., Nice, E. C., Zhang, T., Cui, Y., & Huang, C. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00213-8 · Cited by 544

Glucose transporters in cancer – from tumor cells to the tumor microenvironment

Ancey, P., Contat, C., & Meylan, E. (2018) · FEBS Journal · doi:10.1111/febs.14577 · Cited by 531

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

Wang, Y., Lu, J.-H., Wu, Q.-N., Jin, Y., Wang, D.-S., Chen, Y.-X., Liu, J., Luo, X.-J., Meng, Q., Pu, H.-Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1105-0 · Cited by 507

Heterochromatin: Guardian of the Genome

Janssen, A., Colmenares, S. U., & Karpen, G. H. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062653 · Cited by 500

The evolving metabolic landscape of chromatin biology and epigenetics

Dai, Z., Ramesh, V., & Locasale, J. W. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0270-8 · Cited by 508

Cancer epigenetics: Moving forward

Nebbioso, A., Tambaro, F. P., Dell’Aversana, C., & Altucci, L. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007362 · Cited by 500

Evaluating intrinsic and non-intrinsic cancer risk factors

Wu, S., Zhu, W., Thompson, P. A., & Hannun, Y. A. (2018) · Nature Communications · doi:10.1038/s41467-018-05467-z · Cited by 473

Advances in Targeting ‘Undruggable’ transcription Factors With Small Molecules

Henley, M. J., & Koehler, A. N. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00199-0 · Cited by 409

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Wang, H., Fan, Z., Shliaha, P. V., Miele, M., Hendrickson, R. C., Jiang, X., & Helin, K. (2023) · Nature · doi:10.1038/s41586-023-05780-8 · Cited by 422

The language of chromatin modification in human cancers

Zhao, S., Allis, C. D., & Wang, G. G. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00357-x · Cited by 420

Single‐cell RNA sequencing in cancer research

Zhang, Y., Wang, D., Miao, P., Tang, L. M., Ouyang, J., Xiong, F., Guo, C. J., Tang, Y., Zhou, Y., Liao, Q., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01874-1 · Cited by 412

Anticancer drug resistance: An update and perspective

Nussinov, R., Tsai, C., & Jang, H. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100796 · Cited by 410

The causes of evolvability and their evolution

Payne, J. L., & Wagner, A. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0069-z · Cited by 392

Bridging Bio–Nano Science and Cancer Nanomedicine

Björnmalm, M., Thurecht, K. J., Michael, M., Scott, A. M., & Caruso, F. (2017) · ACS Nano · doi:10.1021/acsnano.7b04855 · Cited by 384

Metastasis-Initiating Cells and Ecosystems

Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Nam, A. S., Chaligné, R., & Landau, D. A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0265-5 · Cited by 399

Sex differences in cancer mechanisms

Rubin, J. B., Lagas, J. S., Broestl, L., Sponagel, J., Rockwell, N., Rhee, G., Rosen, S. F., Chen, S., Klein, R. S., Imoukhuede, P. I., et al. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00291-x · Cited by 391

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance

Zhang, A., Miao, K., Sun, H., & Deng, C. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72534 · Cited by 379

The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML

Vetrie, D. L. P., Helgason, G. V., & Copland, M. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-019-0230-9 · Cited by 365

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

Tamburri, S., Lavarone, E., Fernández-Pérez, D., Conway, E., Zanotti, M., Manganaro, D., & Pasini, D. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.11.021 · Cited by 360

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

Yang, D., Jones, M. G., Naranjo, S., Rideout, W. M., Min, K. H., Ho, R., Wu, W., Replogle, J. M., Page, J. L., Quinn, J. J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.04.015 · Cited by 349

Epigenetic modulation of antitumor immunity for improved cancer immunotherapy

Dai, E., Zhu, Z., Wahed, S., Qu, Z., Storkus, W. J., & Guo, Z. S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01464-x · Cited by 346

The Glioma Stem Cell Model in the Era of Single-Cell Genomics

Suvà, M. L., & Tirosh, I. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.04.001 · Cited by 334

Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunitiesPreprint

Rambow, F., Marine, J., & Goding, C. R. (2019) · Genes & Development · doi:10.1101/gad.329771.119 · Cited by 348

T cell receptor‐based cancer immunotherapy: Emerging efficacy and pathways of resistance

Chandran, S. S., & Klebanoff, C. A. (2019) · Immunological Reviews · doi:10.1111/imr.12772 · Cited by 337

Heterogeneity of the tumor immune microenvironment and its clinical relevance

Jia, Q., Wang, A., Yuan, Y., Zhu, B., & Long, H. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00277-y · Cited by 332

CD44 regulates epigenetic plasticity by mediating iron endocytosis

Müller, S., Sindikubwabo, F., Cañeque, T., Lafon, A., Versini, A., Lombard, B., Loew, D., Wu, T., Ginestier, C., Charafe‐Jauffret, E., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-0513-5 · Cited by 309

Genetic and non-genetic clonal diversity in cancer evolution

Black, J. R., & McGranahan, N. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00336-2 · Cited by 298

Chemical and Biochemical Perspectives of Protein Lysine Methylation

Luo, M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00008 · Cited by 295

Chromatin replication and epigenetic cell memory

Stewart-Morgan, K. R., Petryk, N., & Groth, A. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0487-y · Cited by 290

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

Bhat, G. R., Sethi, I., Sadida, H. Q., Rah, B., Mir, R., Algehainy, N. A., Albalawi, I. A., Masoodi, T., Subbaraj, G. K., Jamal, F., et al. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10172-z · Cited by 330

Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential

Xu, X., Qiu, P., Jiang, X., Tan, S., Yang, Y., Yang, W., Han, Y., Chen, Y., Oyang, L., Lin, J., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01020-1 · Cited by 293

Polytherapy and Targeted Cancer Drug Resistance

Chatterjee, N., & Bivona, T. G. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.02.003 · Cited by 277

Epigenetic heterogeneity in cancer

Guo, M., Peng, Y., Gao, A., Du, C., & Herman, J. G. (2019) · Biomarker Research · doi:10.1186/s40364-019-0174-y · Cited by 288

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Johnson, K. C., Anderson, K. J., Courtois, E. T., Gujar, A. D., Barthel, F. P., Varn, F. S., Luo, D., Seignon, M., Yi, E. S., Kim, H., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00926-8 · Cited by 277

The Genetic/Non-genetic Duality of Drug ‘Resistance’ in Cancer

Salgia, R., & Kulkarni, P. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.01.001 · Cited by 264

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

Gaiti, F., Chaligne, R., Gu, H., Brand, R. M., Kothen-Hill, S., Schulman, R. C., Grigorev, K., Risso, D., Kim, K.-T., Pastore, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1198-z · Cited by 262

DNA methylation in mammalian development and disease

Smith, Z. D., Hetzel, S., & Meissner, A. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00760-8 · Cited by 310

Clonal expansion in non-cancer tissues

Kakiuchi, N., & Ogawa, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00335-3 · Cited by 252

Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options

So, J. Y., Ohm, J. E., Lipkowitz, S., & Li, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108253 · Cited by 269

The Mechanisms of HBV-Induced Hepatocellular Carcinoma

Jiang, Y., Han, Q., Zhao, H., & Zhang, J. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s307962 · Cited by 262

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs

Flavahan, W. A., Drier, Y., Johnstone, S. E., Hemming, M. L., Tarjan, D. R., Hegazi, E., Shareef, S. J., Javed, N. M., Raut, C. P., Eschle, B. K., et al. (2019) · Nature · doi:10.1038/s41586-019-1668-3 · Cited by 258

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

Hinohara, K., Wu, H.-J., Vigneau, S., McDonald, T. O., Igarashi, K. J., Yamamoto, K. N., Madsen, T., Fassl, A., Egri, S. B., Papanastasiou, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.10.014 · Cited by 255

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects

Chen, A.-N., Luo, Y., Yang, Y.-H., Fu, J.-T., Geng, X.-M., Shi, J.-P., & Yang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688910 · Cited by 324

Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

Chaligné, R., Gaiti, F., Silverbush, D., Schiffman, J. S., Weisman, H. R., Kluegel, L., Gritsch, S., Deochand, S. D., Castro, L. N. G., Richman, A. R., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00927-7 · Cited by 247

Epigenetics of Aging and Aging-Associated Diseases

Saul, D., & Kosinsky, R. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010401 · Cited by 247

Current Landscape of Non-Small Cell Lung Cancer: Epidemiology, Histological Classification, Targeted Therapies, and Immunotherapy

Rodak, O., Peris‐Díaz, M. D., Olbromski, M., Podhorska‐Okołów, M., & Dzięgiel, P. (2021) · Cancers · doi:10.3390/cancers13184705 · Cited by 250

Chemistry and biology of ferritin

Plays, M., Müller, S., & Rodriguez, R. (2021) · Metallomics · doi:10.1093/mtomcs/mfab021 · Cited by 232

Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

Stowers, R. S., Shcherbina, A., Israeli, J., Gruber, J. J., Chang, J., Nam, S., Rabiee, A., Teruel, M. N., Snyder, M. P., Kundaje, A. B., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0420-5 · Cited by 227

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

Zhang, H., Pandey, S., Travers, M. E., Sun, H., Morton, G. C., Madžo, J., Chung, W., Khowsathit, J., Pérez, Ó. C., Barrero, C. A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.051 · Cited by 223

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

LaFave, L. M., Kartha, V. K., Ma, S., Meli, K., Priore, I. S. D., Lareau, C. A., Naranjo, S., Westcott, P. M. K., Duarte, F. M., Sankar, V., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.006 · Cited by 216

Landscape of G-quadruplex DNA structural regions in breast cancer

Hänsel-Hertsch, R., Simeone, A., Shea, A., Hui, W. W. I., Zyner, K. G., Marsico, G., Rueda, O. M., Bruna, A., Martin, A., Zhang, X., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0672-8 · Cited by 223

The role of tumor-associated macrophages in tumor immune evasion

Huang, R., Kang, T., & Chen, S. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05777-4 · Cited by 230

The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function

Ma, L., Chen, T., Zhang, X., Miao, Y., Tian, X., Yu, K., Xu, X., Niu, Y., Guo, S., Zhang, C., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101801 · Cited by 223

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

Burdziak, C., Alonso‐Curbelo, D., Walle, T., Reyes, J. S., Barriga, F. M., Haviv, D., Xie, Y., Zhao, Z., Zhao, C. J., Chen, H.-A., et al. (2023) · Science · doi:10.1126/science.add5327 · Cited by 213

Squamous cell lung cancer: Current landscape and future therapeutic options

Lau, S. C. M., Pan, Y., Velcheti, V., & Wong, K. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.09.018 · Cited by 215

Clinical potential of mass spectrometry-based proteogenomics

Zhang, B., Whiteaker, J. R., Hoofnagle, A. N., Baird, G. S., Rodland, K. D., & Paulovich, A. G. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0135-7 · Cited by 210

Cancer gene mutation frequencies for the U.S. population

Mendiratta, G., Ke, E., Aziz, M., Liarakos, D., Tong, M. M., & Stites, E. C. (2021) · Nature Communications · doi:10.1038/s41467-021-26213-y · Cited by 225

Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance

Angelis, M. L. D., Francescangeli, F., Torre, F. L., & Zeuner, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00626 · Cited by 209

Endogenous Retroelements and the Viral Mimicry Response in Cancer Therapy and Cellular Homeostasis

Chen, R. E., Ishak, C. A., & Carvalho, D. D. D. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0506 · Cited by 213

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Smith, Z. D., Shi, J., Gu, H., Donaghey, J., Clement, K., Cacchiarelli, D., Gnirke, A., Michor, F., & Meissner, A. (2017) · Nature · doi:10.1038/nature23891 · Cited by 201

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

Rah, B., Rather, R. A., Bhat, G. R., Baba, A. B., Mushtaq, I., Farooq, M., Yousuf, T., Dar, S. B., Parveen, S., Hassan, R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.821344 · Cited by 202

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities

Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症：英文版 · doi:10.1002/cac2.12374 · Cited by 220

The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome

Gujar, H., Weisenberger, D. J., & Liang, G. (2019) · Genes · doi:10.3390/genes10020172 · Cited by 210

KRAS drives immune evasion in a genetic model of pancreatic cancer

Ischenko, I., D’Amico, S., Rao, M., Li, J., Hayman, M. J., Powers, S., Petrenko, O., & Reich, N. C. (2021) · Nature Communications · doi:10.1038/s41467-021-21736-w · Cited by 192

Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

Yamagishi, M., Hori, M., Fujikawa, D., Ohsugi, T., Honma, D., Adachi, N., Katano, H., Hishima, T., Kobayashi, S., Nakano, K., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.083 · Cited by 191

Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer

Cabanos, H. F., & Hata, A. N. (2021) · Cancers · doi:10.3390/cancers13112666 · Cited by 189

Linking cell mechanical memory and cancer metastasis

Cambria, E., Coughlin, M. F., Floryan, M. A., Offeddu, G. S., Shelton, S. E., & Kamm, R. D. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-023-00656-5 · Cited by 204

Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy

Knudsen, E. S., Pruitt, S. C., Hershberger, P. A., Witkiewicz, A. K., & Goodrich, D. W. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.03.005 · Cited by 190

Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future

Akhoundova, D., & Rubin, M. A. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.08.011 · Cited by 198

Principles and mechanisms of non-genetic resistance in cancer

Bell, C. C., & Gilan, O. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0648-6 · Cited by 190

Transient loss of Polycomb components induces an epigenetic cancer fate

Parreno, V., Loubière, V., Schuettengruber, B., Fritsch, L., Rawal, C. C., Erokhin, M., Győrffy, B., Normanno, D., Stefano, M. D., Moreaux, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07328-w · Cited by 180

A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1109 · Cited by 174

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

Sharma, A., Cao, E. Y., Kumar, V., Zhang, X., Leong, H. S., Wong, A. M. L., Ramakrishnan, N., Hakimullah, M., Teo, H. M. V., Chong, F. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07261-3 · Cited by 159

Role of the oral microbiota in cancer evolution and progression

Sun, J., Tang, Q., Yu, S., Xie, M., Xie, Y., Chen, G., & Chen, L. (2020) · Cancer Medicine · doi:10.1002/cam4.3206 · Cited by 161

Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

Zhou, S., Zhong, Q., Wang, Y., Hu, P., Zhong, W. H., Huang, C., Yu, Z., Ding, C., Liu, H., & Fu, J. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214309 · Cited by 157

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Hass, R., von der Ohe, J., & Ungefroren, H. (2020) · Cancers · doi:10.3390/cancers12123716 · Cited by 154

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Sadida, H. Q., Abdulla, A., Marzooqi, S. A., Hashem, S., Macha, M. A., Akil, A. S. A.-S., & Bhat, A. A. (2024) · Translational Oncology · doi:10.1016/j.tranon.2023.101821 · Cited by 151

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Aramini, B., Masciale, V., Grisendi, G., Bertolini, F., Maur, M., Guaitoli, G., Isca, C., Morandi, U., Stella, F., Dominici, M., et al. (2022) · Cancers · doi:10.3390/cancers14040976 · Cited by 154

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Tallen, G. R. N., Yang, Y., & Riabowol, K. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00027-1