The intestinal epithelium: central coordinator of mucosal immunity

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771 · see citing works

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

van der Flier, L. G., & Clevers, H. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,859 · see citing works

A single-cell survey of the small intestinal epithelium

Haber, A. L., Biton, M., Rogel, N., Herbst, R. H., Shekhar, K., Smillie, C., Burgin, G., Delorey, T. M., Howitt, M. R., Katz, Y., et al. (2017) · Nature · doi:10.1038/nature24489 · Cited by 1,750 · see citing works

Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function

Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716 · see citing works

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,437 · see citing works

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411 · see citing works

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335 · see citing works

Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

Roediger, W. E. (1980) · Gut · doi:10.1136/gut.21.9.793 · Cited by 1,310 · see citing works

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288 · see citing works

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Byndloss, M. X., Olsan, E. E., Rivera-Chávez, F., Tiffany, C. R., Cevallos, S. A., Lokken, K. L., Torres, T. P., Byndloss, A. J., Faber, F., Gao, Y., et al. (2017) · Science · doi:10.1126/science.aam9949 · Cited by 1,237 · see citing works

Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit

von Moltke, J., Ji, M., Liang, H.-E., & Locksley, R. M. (2016) · Nature · doi:10.1038/nature16161 · Cited by 1,230 · see citing works

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L., & Hooper, L. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808723105 · Cited by 1,019 · see citing works

Host-Derived Nitrate Boosts Growth of <i>E. coli</i> in the Inflamed Gut

Winter, S. E., Winter, M. G., Xavier, M. N., Thiennimitr, P., Poon, V., Keestra, A. M., Laughlin, R. C., Gomez, G., Wu, J., Lawhon, S. D., et al. (2013) · Science · doi:10.1126/science.1232467 · Cited by 1,019 · see citing works

Immunological aspects of intestinal mucus and mucins

Johansson, M. E. V., & Hansson, G. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.88 · Cited by 1,007 · see citing works

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 997 · see citing works

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

Mcdole, J. R., Wheeler, L. W., McDonald, K. G., Wang, B., Konjufca, V. H., Knoop, K. A., Newberry, R. D., & Miller, M. J. (2012) · Nature · doi:10.1038/nature10863 · Cited by 976 · see citing works

Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling

Levy, M., Thaiss, C. A., Zeevi, D., Dohnalová, L., Zilberman-Schapira, G., Mahdi, J. A., David, E., Savidor, A., Korem, T., Herzig, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.048 · Cited by 960 · see citing works

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

Gerbe, F., Sidot, E., Smyth, D. J., Ohmoto, M., Matsumoto, I., Dardalhon, V., Cesses, P., Garnier, L., Pouzolles, M., Brulin, B., et al. (2016) · Nature · doi:10.1038/nature16527 · Cited by 944 · see citing works

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

Howitt, M. R., Lavoie, S., Michaud, M., Blum, A. M., Tran, S. V., Weinstock, J. V., Gallini, C. A., Redding, K., Margolskee, R. F., Osborne, L. C., et al. (2016) · Science · doi:10.1126/science.aaf1648 · Cited by 904 · see citing works

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Aglietti, R. A., Estevez, A., Gupta, A., Ramirez, M. G., Liu, P. S., Kayagaki, N., Ciferri, C., Dixit, V. M., & Dueber, E. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607769113 · Cited by 898 · see citing works

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

Rivera-Chávez, F., Zhang, L. F., Faber, F., Lopez, C. A., Byndloss, M. X., Olsan, E. E., Xu, G., Velazquez, E. M., Lebrilla, C. B., Winter, S. E., et al. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.03.004 · Cited by 864 · see citing works

New developments in goblet cell mucus secretion and function

Birchenough, G. M. H., Johansson, M., Gustafsson, J. K., Bergström, J. H., & Hansson, G. C. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.32 · Cited by 820 · see citing works

Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works

Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

Crosnier, C., Stamataki, D., & Lewis, J. H. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1840 · Cited by 756 · see citing works

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

Kaiko, G. E., Ryu, H., Koues, O. I., Collins, P. L., Solnica‐Krezel, L., Pearce, E. J., Pearce, E. L., Oltz, E. M., & Stappenbeck, T. S. (2016) · Cell · doi:10.1016/j.cell.2016.05.018 · Cited by 738 · see citing works

Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor

Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702 · see citing works

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

Cario, E., Gerken, G., & Podolsky, D. K. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.056 · Cited by 697 · see citing works

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

Gribble, F. M., & Reimann, F. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105439 · Cited by 683 · see citing works

Regulation of inflammation by microbiota interactions with the host

Blander, J. M., Longman, R., Iliev, I. D., Sonnenberg, G. F., & Artis, D. (2017) · Nature Immunology · doi:10.1038/ni.3780 · Cited by 649 · see citing works

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

Bergstrom, K. S. B., Kissoon-Singh, V., Gibson, D. L., Ma, C., Montero, M., Sham, H. P., Ryz, N., Huang, T., Velcich, A., Finlay, B. B., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000902 · Cited by 625 · see citing works

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

Lee, J., Mo, J., Katakura, K., Alkalay, I., Rucker, A. N., Liu, Y., Lee, H., Shen, C., Cojocaru, G., Shenouda, S., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1500 · Cited by 621 · see citing works

An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism

Rosenblatt, J., RAFF, M. C., & Cramer, L. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00587-5 · Cited by 602 · see citing works

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Birchenough, G. M. H., Nyström, E. E. L., Johansson, M. E. V., & Hansson, G. C. (2016) · Science · doi:10.1126/science.aaf7419 · Cited by 568 · see citing works

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Nowarski, R., Jackson, R. P., Gagliani, N., de Zoete, M. R., Palm, N. W., Bailis, W., Low, J. S., Harman, C. C. D., Graham, M. M., Elinav, E., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.072 · Cited by 564 · see citing works

Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions

Li, L., Dong, J., Yan, L., Yong, J., Liu, X., Hu, Y., Fan, X., Wu, X., Guo, H., Wang, X., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.007 · Cited by 562 · see citing works

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549 · see citing works

Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against <i>Clostridium difficile</i>

Rea, M. C., Sit, C. S., Clayton, E., O'Connor, P. M., Whittal, R. M., Zheng, J., Vederas, J. C., Ross, R. P., & Hill, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913554107 · Cited by 530 · see citing works

Interplay between metabolic identities in the intestinal crypt supports stem cell function

Rodríguez-Colman, M. J., Schewe, M., Meerlo, M., Stigter, E., Gerrits, J., Pras-Raves, M., Sacchetti, A., Hornsveld, M., Oost, K. C., Snippert, H. J., et al. (2017) · Nature · doi:10.1038/nature21673 · Cited by 522 · see citing works

Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases

Dupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517 · see citing works

Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice

Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451 · see citing works

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

Knodler, L. A., Crowley, S. M., Sham, H. P., Yang, H., Wrande, M., Ma, C., Ernst, R. K., Steele‐Mortimer, O., Celli, J., & Vallance, B. A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.07.002 · Cited by 430 · see citing works

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

Park, S.-W., Zhen, G., Verhaeghe, C., Nakagami, Y., Nguyenvu, L. T., Barczak, A. J., Killeen, N. P., & Erle, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808722106 · Cited by 418 · see citing works

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

Sellin, M. E., Müller‐Hauser, A. A., Felmy, B., Dolowschiak, T., Diard, M., Tardivel, A., Maslowski, K. M., & Hardt, W. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.07.001 · Cited by 404 · see citing works

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

Jorgensen, I., Zhang, Y., Krantz, B. A., & Miao, E. A. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151613 · Cited by 403 · see citing works

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

Rauch, I., Deets, K. A., Ji, D. X., von Moltke, J., Tenthorey, J. L., Lee, A. Y., Philip, N. H., Ayres, J. S., Brodsky, I. E., Gronert, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.016 · Cited by 403 · see citing works

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

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Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

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Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Hara, H., Tsuchiya, K., Kawamura, I., Fang, R., Hernández-Cuellar, E., Shen, Y., Mizuguchi, J., Schweighoffer, E., Tybulewicz, V. L. J., & Mitsuyama, M. (2013) · Nature Immunology · doi:10.1038/ni.2749 · Cited by 382 · see citing works

Effect of broad- and narrow-spectrum antimicrobials on <i>Clostridium difficile</i> and microbial diversity in a model of the distal colon

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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

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Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

Johansson, M. E. V., Gustafsson, J. K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H., & Hansson, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012238 · Cited by 368 · see citing works

M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells

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Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing

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RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract

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Phosphorylation of NLRC4 is critical for inflammasome activation

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Induction of Human β-Defensin 2 by the ProbioticEscherichia coliNissle 1917 Is Mediated through Flagellin

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Oxygen as a driver of gut dysbiosis

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TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

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Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

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Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse

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Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

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Accounting for reciprocal host–microbiome interactions in experimental science

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Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

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Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

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Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

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Intestinal M cells

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Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

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Commensal bacteria direct selective cargo sorting to promote symbiosis

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Skn-1a (Pou2f3) specifies taste receptor cell lineage

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