The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Visualizing the function and fate of neutrophils in sterile injury and repair
Abstract
Imaging the unforeseen fate of neutrophils: Inflammation that results from insults such as ischemia and reperfusion or trauma in the absence of microorganisms is known as “sterile inflammation.” Neutrophils are recruited in vast numbers during sterile inflammation and have been thought to play a detrimental role. Wang et al. used intravital microscopy to show that neutrophils actually perform helpful tasks such as removing and regenerating thermally damaged blood vessels in the liver (see the Perspective by Garner and de Visser). Moreover, neutrophils neither die nor are phagocytosed. Instead, they return to the circulation in a process called “reverse transmigration,” making a pit stop in the lungs, before ending their lives where they began—in the bone marrow. Thus, a reconsideration of the use of anti-neutrophil therapies after injury may be warranted. Science , this issue p. 111 ; see also p. 42
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NIH Image to ImageJ: 25 years of image analysis
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Sterile inflammation: sensing and reacting to damage
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Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
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Self-citationPhagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959
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Neutrophil function in inflammation and inflammatory diseases
Wright, H. L., Moots, R. J., Bucknall, R. C., & Edwards, S. W. (2010) · Rheumatology · doi:10.1093/rheumatology/keq045 · Cited by 761
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Self-citationResolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
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Cited by
Kubes, P., & Jenne, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052415 · Cited by 923
Self-citationHepatic inflammatory responses in liver fibrosis
Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803
Neutrophils and NETS in modulating acute and chronic inflammation
Castanheira, F. V. S., & Kubes, P. (2019) · Blood · doi:10.1182/blood-2018-11-844530 · Cited by 792
Self-citationNeutrophil chemoattractant receptors in health and disease: Double-edged swords
Metzemaekers, M., Gouwy, M., & Proost, P. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0412-0 · Cited by 570
Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564
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Metadata
- Authors
- Wang, J., Hossain, M., Thanabalasuriar, A., Gunzer, M., Meininger, C., & Kubes, P.
- Venue
- Science
- Published
- 2017-10-06
- Volume
- 358
- Issue
- 6359
- Pages
- 111-116
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2763257724
- Cited by
- 508
- References
- 27
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
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